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    FURA 2-AM

    Available from stock

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      FURA 2-AM

      SKU
      F0014

      Category: Fluorescent Detection

      Synonyms
      Fura-2 acetoxymethyl ester , Fura-2 pentakis(acetoxymethyl) ester
      108964-32-5
      CAS-Number
      C44H47N3O24
      Molecular Formula
      1001.87
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥95% (HPLC)
      Identity
      1H-NMR
      Appearance
      Yellow solid

      Properties

      Optical Activity
      Wavelength 370 +/-3 nm
      Solvents
      DMSO

      Downloads

      Safety Data Sheet
      CDX F0014 MSDS.pdf
      Short Term Storage
      -20°C
      Use / Stability
      Stable for at least 2 years after receipt when stored at -20°C.
      Handling Advice
      Protect from light and moisture.
      Long Term Storage
      -20°C
      Shipping
      AMBIENT
      Transportation
      Not dangerous goods
      Description
      The fluorescent probe FURA 2/AM is a membrane-permeable derivative of the calcium chelator FURA 2. Inside cells, FURA 2/AM is rapidly hydrolyzed by cytoplasmic esterases to FURA 2, which remains within the cell. Non-invasive, intracellular calcium indicator that is UV light-excitable. Fluorescent Ca2+ indicator, selective for Ca2+ over other divalent cations Mg2+, Zn2+, Fe2+ and Mn2+. FURA 2/AM is used to determine calcium concentrations in many cellular systems, including: cardiac myocytes, vascular smooth muscle cells and medullary collecting tubules. Spectral properties in the presence of low calcium concentrations (?ex = 362nm, ?em = 512nm) differ from those during high calcium conditions (?ex = 335nm, ?em = 505nm). FURA 2 is preferred for ratio-imaging microscopy, in which it is more practical to change excitation wavelengths than emission wavelengths. Spectral Data: λex 355nm, λem 495nm in 0.1 M Tris pH 8.0.
      InChi
      InChI=1S/C44H47N3O24/c1-25-7-8-32(46(16-39(53)65-20-60-26(2)48)17-40(54)66-21-61-27(3)49)35(11-25)58-9-10-59-36-12-31-13-37(43-45-15-38(71-43)44(57)69-24-64-30(6)52)70-34(31)14-33(36)47(18-41(55)67-22-62-28(4)50)19-42(56)68-23-63-29(5)51/h7-8,11-15H,9-10,16-24H2,1-6H3
      References
      (1) G. Grynkiewicz, et al., J. Biol. Chem. 260, 3440 (1985) , (2) I. Maruyama, et al., FEBS Lett. 220, 89 (1987) , (3) M.E. Janconi, et al., J. Cell Biol. 110, 1555 (1990) , (4) Y. Schwartz, et al., Endocrinology 131, 772 (1992) , (5) G.H. Rao, et al., Biochem. Med. Metab. Biol. 47, 226 (1992) , (6) M.J.Davis, et al., Am. J. Physiol. 263, H1292 (1992) , (7) M.J. Davis, et al., Am. J. Physiol. 263, H1292 (1992) , (8) M.L. Field, et al., Cell Calcium. 16, 87 (1994) , (9) R.W. Sabnis, Handbook of biological dyes and stains (2010)
      InChi Key
      VPSRLGDRGCKUTK-UHFFFAOYSA-N
      Smiles
      O=C(OCOC(C)=O)C1=CN=C(O1)C2=CC3=C(O2)C=C(N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)C(OCCOC4=C(N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)C=CC(C)=C4)=C3

      The fluorescent probe FURA 2/AM is a membrane-permeable derivative of the calcium chelator FURA 2. Inside cells, FURA 2/AM is rapidly hydrolyzed by cytoplasmic esterases to FURA 2, which remains within the cell. Non-invasive, intracellular calcium indicator that is UV light-excitable. Fluorescent Ca2+ indicator, selective for Ca2+ over other divalent cations Mg2+, Zn2+, Fe2+ and Mn2+. FURA 2/AM is used to determine calcium concentrations in many cellular systems, including: cardiac myocytes, vascular smooth muscle cells and medullary collecting tubules. Spectral properties in the presence of low calcium concentrations (?ex = 362nm, ?em = 512nm) differ from those during high calcium conditions (?ex = 335nm, ?em = 505nm). FURA 2 is preferred for ratio-imaging microscopy, in which it is more practical to change excitation wavelengths than emission wavelengths. Spectral Data: λex 355nm, λem 495nm in 0.1 M Tris pH 8.0.

      SKU: F0014 Category: Fluorescent Detection
      • Additional information

      Additional information

      Synonyms

      Fura-2 acetoxymethyl ester, Fura-2 pentakis(acetoxymethyl) ester

      Purity

      ≥95% (HPLC)

      Appearance

      Yellow solid

      CAS-Number

      108964-32-5

      Molecular Formula

      C44H47N3O24

      Molecular Weight

      1001.87

      Identity

      1H-NMR

      Solvents

      DMSO

      Optical Activity

      Wavelength 370 +/-3 nm

      Smiles

      O=C(OCOC(C)=O)C1=CN=C(O1)C2=CC3=C(O2)C=C(N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)C(OCCOC4=C(N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)C=CC(C)=C4)=C3

      InChi Key

      VPSRLGDRGCKUTK-UHFFFAOYSA-N

      Shipping

      AMBIENT

      Short Term Storage

      -20°C

      Long Term Storage

      -20°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at -20°C.

      Transportation

      Not dangerous goods

      References

      (1) G. Grynkiewicz, et al., J. Biol. Chem. 260, 3440 (1985), (2) I. Maruyama, et al., FEBS Lett. 220, 89 (1987), (3) M.E. Janconi, et al., J. Cell Biol. 110, 1555 (1990), (4) Y. Schwartz, et al., Endocrinology 131, 772 (1992), (5) G.H. Rao, et al., Biochem. Med. Metab. Biol. 47, 226 (1992), (6) M.J.Davis, et al., Am. J. Physiol. 263, H1292 (1992), (7) M.J. Davis, et al., Am. J. Physiol. 263, H1292 (1992), (8) M.L. Field, et al., Cell Calcium. 16, 87 (1994), (9) R.W. Sabnis, Handbook of biological dyes and stains (2010)

      InChi

      InChI=1S/C44H47N3O24/c1-25-7-8-32(46(16-39(53)65-20-60-26(2)48)17-40(54)66-21-61-27(3)49)35(11-25)58-9-10-59-36-12-31-13-37(43-45-15-38(71-43)44(57)69-24-64-30(6)52)70-34(31)14-33(36)47(18-41(55)67-22-62-28(4)50)19-42(56)68-23-63-29(5)51/h7-8,11-15H,9-10,16-24H2,1-6H3

      Quantity

      1 mg, Bulk

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