Available from stock

Fusidic acid sodium salt

SKU: F0118

Category: Antibiotics

Synonyms: Fucidin, SQ 16360, Fusidate sodium; 751-94-0
CAS-Number: C₃₁H₄₇O₆Na
Molecular Formula: 538.69
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (TLC)
Appearance: White to off-white powder
Identity: 1H-NMR
Water content (K.F.): ≤2.0%

Properties

Solvents: Soluble in water or DMSO.

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Hazard statements: H302
Precautionary statements: P301 + P312 + P330
GHS Symbol: GHS07
Signal word: Warning
Transportation: Not dangerous goods

Description: The tetracyclic triterpenoid is a fusidane antibiotic originally isolated from F. coccineum. It is active against the Gram-positive bacteria S. aureus, S. pyogenes, C. diphtheriae, B. subtilis, and C. tetani but not the Gram-negative bacteria E. coli, S. typhimurium, and P. vulgaris or the fungi C. albicans and A. fumigatus. This antibacterial agent inhibits bacterial protein synthesis by preventing the release of translation elongation factor G (EF-G) from ribosomes. Fusidic acid has immunomodulatory effects and inhibits the inhibitory and activating effects of interleukins IL-1 and IL-6 on glucose-induced insulin production and exhibits antidiabetic effects in a rat moδ Fusidic acid improves the symptoms of colitis in rats and inhibits the growth of Toxoplasma gondii and Listeria monocytogenes EGD in vitro, but not in mice. The sodium salt version is found to be more water-soluble.
Smiles: O=C(O[Na])/C(CC/C=C(C)/C)=C1[C@@H](OC(C)=O)C[C@]2(C)[C@@]3(C)CC[C@@]4([H])[C@H](C)[C@H](O)CC[C@]4(C)[C@]3([H])[C@H](O)C[C@]2\1[H]
InChi Key: HJHVQCXHVMGZNC-JCJNLNMISA-M
References: (1) W.O. Godtfredsen, et al.; Nature 193, 987 (1962) , (2) N. Tanaka, et al.; Biochem. Biophys. Res. Commun. 30, 278 (1968) , (3) L. Verbist; J. Antimicrob. Chemother. 25, 1 (1990) , (4) K. Bendtzen, et al.; J. Endocrinol. 132, 345 (1992) , (5) K. Buschard, et al.; Autoimmunity 14, 101 (1992) , (6) J Turnidge, et al.; Int. J. Antimicrob. Agents 12, S23 (1999) , (7) P. Collignon & L. Turnidge; Int. J. Antimicrob. Agents 12, S45 (1999) , (8) K. Christiansen; Int. J. Antimicrob. Agents 12, S73 (1999) , (9) A. Savelsbergh, et al.; RNA 15, 772 (2009)
InChi: InChI= 1S/C31H48O6.Na/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32;/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36);/q;+1/p-1/b26-20-;/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-;/m0./s1

The tetracyclic triterpenoid is a fusidane antibiotic originally isolated from F. coccineum. It is active against the Gram-positive bacteria S. aureus, S. pyogenes, C. diphtheriae, B. subtilis, and C. tetani but not the Gram-negative bacteria E. coli, S. typhimurium, and P. vulgaris or the fungi C. albicans and A. fumigatus. This antibacterial agent inhibits bacterial protein synthesis by preventing the release of translation elongation factor G (EF-G) from ribosomes. Fusidic acid has immunomodulatory effects and inhibits the inhibitory and activating effects of interleukins IL-1 and IL-6 on glucose-induced insulin production and exhibits antidiabetic effects in a rat moδ Fusidic acid improves the symptoms of colitis in rats and inhibits the growth of Toxoplasma gondii and Listeria monocytogenes EGD in vitro, but not in mice. The sodium salt version is found to be more water-soluble.

SKU: F0118 Category: Antibiotics

Additional information

Additional information

Synonyms	Fucidin, SQ 16360, Fusidate sodium
Purity	≥98% (TLC)
Appearance	White to off-white powder
CAS-Number	751-94-0
Molecular Formula	C31H47O6Na
Molecular Weight	538.69
Identity	1H-NMR
Solvents	Soluble in water or DMSO.
Smiles	O=C(O[Na])/C(CC/C=C(C)/C)=C1[C@@H](OC(C)=O)C[C@]2(C)[C@@]3(C)CC[C@@]4([H])[C@H](C)[C@H](O)CC[C@]4(C)[C@]3([H])[C@H](O)C[C@]2\1[H]
InChi Key	HJHVQCXHVMGZNC-JCJNLNMISA-M
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements	H302
Precautionary statements	P301 + P312 + P330
GHS Symbol	GHS07
Signal word	Warning
Transportation	Not dangerous goods
References	(1) W.O. Godtfredsen, et al.; Nature 193, 987 (1962), (2) N. Tanaka, et al.; Biochem. Biophys. Res. Commun. 30, 278 (1968), (3) L. Verbist; J. Antimicrob. Chemother. 25, 1 (1990), (4) K. Bendtzen, et al.; J. Endocrinol. 132, 345 (1992), (5) K. Buschard, et al.; Autoimmunity 14, 101 (1992), (6) J Turnidge, et al.; Int. J. Antimicrob. Agents 12, S23 (1999), (7) P. Collignon & L. Turnidge; Int. J. Antimicrob. Agents 12, S45 (1999), (8) K. Christiansen; Int. J. Antimicrob. Agents 12, S73 (1999), (9) A. Savelsbergh, et al.; RNA 15, 772 (2009)
InChi	InChI= 1S/C31H48O6.Na/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32;/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36);/q;+1/p-1/b26-20-;/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-;/m0./s1
Quantity	1 g, Bulk
cdx-Water content (K.F.)	≤2.0%