Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- Light yellow powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (20 mg/ml), DMF (20 mg/ml), ethanol (10 mg/ml)
- Melting Point
- 214-215 °C(lit.)
Category: Phytochemicals
Galangin is a flavonoid naturally found in herbs used in traditional medicine. It has diverse biological activities, including potent antioxidant, anti-inflammatory, antiobesity, antidiabetic, anti-cancer, neuroprotective, antiviral and antibacterial properties. Galangin has anti-inflammatory actions related to suppression of signaling through NF-?B/NRLP3 pathway. Galangin induces apoptosis and autophagy in different cancer cells. It is a TRPC5 inhibitor, inhibiting Ca2+ entry into TRPC5 expressing cells. Galangin as a potential DPP-4 inhibitor that improves insulin-stimulated skeletal muscle glucose uptake.
Synonyms | 3,5,7-Trihydroxyflavone, Norizalpinin, NSC 407229 |
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Purity | ≥98% (HPLC) |
Appearance | Light yellow powder |
CAS-Number | 548-83-4 |
Molecular Formula | C15H10O5 |
Molecular Weight | 270.24 |
Identity | 1H-NMR |
Solvents | DMSO (20 mg/ml), DMF (20 mg/ml), ethanol (10 mg/ml) |
Melting Point | 214-215 °C(lit.) |
Smiles | OC1=C2C(OC(C3=CC=CC=C3)=C(O)C2=O)=CC(O)=C1 |
InChi Key | VCCRNZQBSJXYJD-UHFFFAOYSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Hazard statements | H315-H319-H335 |
Precautionary statements | P261-P305 + P351 + P338 |
GHS Symbol | GHS07 |
Signal word | Warning |
Transportation | Not dangerous goods |
References | (1) J.J. Meyer, et al., J. Ethnopharmacol. 56, 165 (1997), (2) S. Pepeljnjak & I. Kosalec, FEMS Microbiol. Lett. 240, 111 (2004), (3) H.T. Zhang, et al., World J. Gastroenterol. 16, 3377 (2010), (4) M. Wen, et al., Pharmacology 89, 247 (2012), (5) W. Zhang, et al., J. Cell Biochem. 114, 152 (2013), (6) S. Kumar & K.R. Alagawadi, Pharm. Biol. 51, 607 (2013), (7) S. Shaikh, et al., CNS Neurol. Disord. Drug Targets 13, 452 (2014), (8) Y.C. Jung, et al., Immunopharmacol. Immunotoxicol. 36, 426 (2014), (9) J. Naylor, et al., Br. J. Pharmacol. 173, 562 (2016), (10) G. Chen, et al., Int. J. Mol. Sci. 19, E12 (2017), (11) A.A. Aloud, et al., Redox Rep. 23, 29 (2018), (12) Q. Fu, et al., Mol. Med. Rep. 18, 3619 (2018), (13) M.E. Kim, et al., Mol. Cell Biochem. 451, 145 (2019), (14) P. Kalhotra, et al., Int. J. Mol. Sci. 20, E1228 (2019) |
InChi | InChI=1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H |
Quantity | 25 mg, 100 mg, Bulk |