Gentamicin sulfate

Specifications

Appearance

White to off-white powder

Optical Activity

+107.0 to +121.0

Water content (K.F.)

≤18.0%

Properties

Solvents

water (50 mg/ml)

Optical Activity

+107°- +121°

Shipping

AMBIENT

Short Term Storage

RT

Long Term Storage

+4°C

Handling Advice

Protect from light and air. Store under inert gas.

Use / Stability

Stable for at least 2 years after receipt when stored at +4°C.

Hazard statements

H317

Precautionary statements

P280

GHS Symbol

GHS07

Signal word

Warning

Transportation

Not dangerous goods

Description

Gentamicin sulfate is a broad-spectrum aminoglycoside antibiotic used to treat a wide range of bacterial infections. It is antibacterial against Gram-negative aerobic bacteria, Gram-positive bacteria and mycoplasmas. Gentamicin sulfate is a protein synthesis inhibitor. It causes codon misreading by binding to the 30S ribosomal subunit, blocking the translocation of peptidyl-tRNA from the acceptor site to the donor site. Gentamicin sulfate is used as a selection agent (gentamicin-resistance gene) in molecular biology applications. It is a broad-spectrum cell culture antibiotic that is nontoxic to viruses and mammalian cells at antibacterial and antimycoplasmal concentrations. Due to its extended stability and slow development of bacterial resistance, it is a useful antibiotic in long-term virus und tissue culture studies.

Smiles

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InChi Key

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References

(1) M. Finland, Med. Times 97, 161 (1969) (Review) , (2) R.E. Hancock, J. Antimicrob. Chemother. 8, 249 (1981) (Review) , (3) E. Hancock, J. Antimicrob. Chemother. 8, 429 (1981) (Review) , (4) N.L. Martin & T.J. Beveridge, Antimicrob. Agents Chemother. 29, 1079 (1986) , (5) J.P. Montenez, et al., Toxicol. Lett. 73, 201 (1994) , (6) F.C. Luft, J. Mol. Med. 80, 543 (2002) (Review) , (7) Y. Quiros, et al., Toxicol. Sci. 119, 245 (2011) (Review)