Available from stock

Ginkgolide A

SKU: G0221

Category: Phytochemicals

Synonyms: BN-52020; 15291-75-5
CAS-Number: C₂₀H₂₄O₉
Molecular Formula: 408.40
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: White powder
Identity: 1H-NMR

Properties

Solvents: DMSO (20 mg/ml), DMF (20 mg/ml), ethanol (3 mg/ml)
Optical Activity: 55.8° (c = 0.5 in ethanol)

Shipping: AMBIENT
Short Term Storage: +4°C
Long Term Storage: -20°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.

Transportation: Not dangerous goods

Description: Ginkgolide A is a terpenoid lactone originally isolated from G. biloba leaves. It shows diverse biological activities, including antioxidant, neuroprotective, anti-inflammatory and antiproliferative effects. Ginkgolide A inhibits platelet activating factor (PAF)-dependent aggregation of human platelets. It inhibits nitric oxide (NO) production. It also shows anxiolytic-like activity. It Inhibits NF-?B activity by NF-?B-specific suppressor I?Bα. Ginkgolide A is a ligand of pregnane X receptor (PXR). It showed hepatoprotective efficacy by inducing cellular lipoapoptosis and by inhibiting cellular inflammation in NAFLD. Ginkgolide A reduced the proliferation rate of OVCA429 ovarian cancer cells by 40%.
Smiles: O=C1[C@@H](C)[C@]([C@](O1)([H])C2)(O)[C@]([C@]32[C@H]4C[C@@H](C(C)(C)C)[C@]53[C@H]6O)(C(O4)=O)O[C@]5([H])OC6=O
InChi Key: FPUXKXIZEIDQKW-VKMVSBOZSA-N
References: (1) H.W. Zhao & X.Y. Li, Int. Immunopharmacol. 2, 1551 (2002) , (2) H. Kuribara, et al., J. Nat. Prod. 66, 1333 (2003) , (3) E. Koch, Phytomedicine 12, 10 (2005) , (4) B. Ye, et al., Cancer Lett. 251, 43 (2007) , (5) Q. Zhao, et al., Int. Immunopharmacol. 25, 242 (2015) , (6) N. Ye, et al., Biomol. Ther. 24, 40 (2016) , (7) J. Zhaocheng, et al., Pharmazie 71, 588 (2016) , (8) H.S. Jeong, et al., Biomed. Pharmacother. 88, 625 (2017) , (9) Y. Li, et al., Int. J. Mol. Sci. 18, E794 (2017) , (10) L.C. Kuo, et al., J. Agric. Food Chem. 67, 81 (2019) , (11) S. Mohandas & B. Vairappan, Chem. Biol. Interact. 315, 108891 (2019) , (12) W. You, et al., Pharmazie 74, 698 (2019)
InChi: InChI=1S/C20H24O9/c1-7-12(22)26-10-6-17-9-5-8(16(2,3)4)18(17)11(21)13(23)28-15(18)29-20(17,14(24)27-9)19(7,10)25/h7-11,15,21,25H,5-6H2,1-4H3/t7-,8+,9-,10+,11+,15+,17-,18+,19-,20-/m1/s1

Ginkgolide A is a terpenoid lactone originally isolated from G. biloba leaves. It shows diverse biological activities, including antioxidant, neuroprotective, anti-inflammatory and antiproliferative effects. Ginkgolide A inhibits platelet activating factor (PAF)-dependent aggregation of human platelets. It inhibits nitric oxide (NO) production. It also shows anxiolytic-like activity. It Inhibits NF-?B activity by NF-?B-specific suppressor I?Bα. Ginkgolide A is a ligand of pregnane X receptor (PXR). It showed hepatoprotective efficacy by inducing cellular lipoapoptosis and by inhibiting cellular inflammation in NAFLD. Ginkgolide A reduced the proliferation rate of OVCA429 ovarian cancer cells by 40%.

SKU: G0221 Category: Phytochemicals

Additional information

Additional information

Synonyms	BN-52020
Purity	≥98% (HPLC)
Appearance	White powder
CAS-Number	15291-75-5
Molecular Formula	C20H24O9
Molecular Weight	408.40
Identity	1H-NMR
Solvents	DMSO (20 mg/ml), DMF (20 mg/ml), ethanol (3 mg/ml)
Optical Activity	55.8° (c = 0.5 in ethanol)
Smiles	O=C1[C@@H](C)[C@]([C@](O1)([H])C2)(O)[C@]([C@]32[C@H]4C[C@@H](C(C)(C)C)[C@]53[C@H]6O)(C(O4)=O)O[C@]5([H])OC6=O
InChi Key	FPUXKXIZEIDQKW-VKMVSBOZSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Transportation	Not dangerous goods
References	(1) H.W. Zhao & X.Y. Li, Int. Immunopharmacol. 2, 1551 (2002), (2) H. Kuribara, et al., J. Nat. Prod. 66, 1333 (2003), (3) E. Koch, Phytomedicine 12, 10 (2005), (4) B. Ye, et al., Cancer Lett. 251, 43 (2007), (5) Q. Zhao, et al., Int. Immunopharmacol. 25, 242 (2015), (6) N. Ye, et al., Biomol. Ther. 24, 40 (2016), (7) J. Zhaocheng, et al., Pharmazie 71, 588 (2016), (8) H.S. Jeong, et al., Biomed. Pharmacother. 88, 625 (2017), (9) Y. Li, et al., Int. J. Mol. Sci. 18, E794 (2017), (10) L.C. Kuo, et al., J. Agric. Food Chem. 67, 81 (2019), (11) S. Mohandas & B. Vairappan, Chem. Biol. Interact. 315, 108891 (2019), (12) W. You, et al., Pharmazie 74, 698 (2019)
InChi	InChI=1S/C20H24O9/c1-7-12(22)26-10-6-17-9-5-8(16(2,3)4)18(17)11(21)13(23)28-15(18)29-20(17,14(24)27-9)19(7,10)25/h7-11,15,21,25H,5-6H2,1-4H3/t7-,8+,9-,10+,11+,15+,17-,18+,19-,20-/m1/s1
Quantity	25 mg, Bulk