Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (30 mg/ml), ethanol (10 mg/ml)
- Melting Point
- 295-296° C
- Refractive Index
- 1.65
Downloads
- Safety Data Sheet
- CDX G0218 MSDS.pdf
Category: Phytochemicals
Ginkgolide B, a terpenoid extracted from G. biloba leaves, is a potent PAFR antagonist that inhibits platelet aggregation. Platelet-activating factor (PAF) is an important mediator of cell proliferation, angiogenesis, inflammatory response regulation, vasodilation, superoxide formation and platelet aggregation. These cellular effects are mediated through its specific G-protein coupled receptor, PAFR. Ginkgolide B has been shown to have anticancer properties by inducing apoptosis and blocking the cell cycle. Ginkgolide B also demonstrates number of other anti-inflammatory, anti-allergic, antioxidant and neuroprotective effects.
Synonyms | BN-52021 |
---|---|
Purity | ≥98% (HPLC) |
Appearance | White powder |
CAS-Number | 15291-77-7 |
Molecular Formula | C20H24O10 |
Molecular Weight | 424.40 |
Identity | 1H-NMR |
Solvents | DMSO (30 mg/ml), ethanol (10 mg/ml) |
Melting Point | 295-296° C |
Refractive Index | 1.65 |
Smiles | O=C1[C@@H](C)[C@]([C@](O1)([H])[C@@H]2O)(O)[C@]([C@]32[C@@]4([H])C[C@@H](C(C)(C)C)[C@]53[C@H]6O)(C(O4)=O)O[C@]5([H])OC6=O |
InChi Key | SQOJOAFXDQDRGF-MMQTXUMRSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Transportation | Not dangerous goods |
References | (1) E. Foldes-Filep, et al., BBRC 148, 1412 (1987), (2) K. Funkunaga, et al., J. Biol. Chem. 276, 43025 (2001), (3) K.M. Maclennan, et al., Prog. Neurobiol. 67, 235 (2002), (4) E.L. Kondratskaya, et al., Brain Res. Bull. 63, 309 (2004), (5) X. Shi-hai & F. Dian-chun, Chin. Med. J. 120, 922 (2007), (6) H.J. Cho & K.S. Nam, J. Biochem. Mol. Biol. 40, 678 (2007), (7) M. Aponte, et al., Cancer Res. 68, 5839 (2008), (8) Y.D. Hsuuw, et al., Ann. N Y Acad. Sci. 1171, 501 (2009), (9) S. Zhang, et al., J. Cardiovasc. Pharmacol. 57, 721 (2011), (10) C. Zhang, et al., Toxicology 287, 124 (2011), (11) X. Chu, et al., Molecules 16, 7634 (2011), (12) W. Jiang, et al., Integr. Cancer Ther. 13, NP10-7 (2012), (13) J.H. Gu, et al., Eur. J. Pharm. Sci. 47, 652 (2012) |
InChi | InChI=1S/C20H24O10/c1-6-12(23)28-11-9(21)18-8-5-7(16(2,3)4)17(18)10(22)13(24)29-15(17)30-20(18,14(25)27-8)19(6,11)26/h6-11,15,21-22,26H,5H2,1-4H3/t6-,7+,8-,9+,10+,11+,15+,17+,18+,19-,20-/m1/s1 |
Quantity | 10 mg, 50 mg, Bulk |