Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to light brown powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO, ethanol, DMF (all 20 mg/ml)
Documentation
- Safety Data Sheet (SDS)
- CDX G0194 MSDS.pdf
Available from stock
Glabridin
- SKU
- G0194
Category: Phytochemicals
- Synonyms
- (R)-4-(3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-yl)-1,3-benzenediol
- 59870-68-7
- CAS-Number
- C20H20O4
- Molecular Formula
- 324.37
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- RT
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at RT.
- Transportation
- Not dangerous goods
- Description
- Glabridin is a prenylated isoflavonoid found in licorice (Glycyrrhiza glabra L.) root extract that is reported to possess antiviral, antimicrobial, anti-inflammatory, antidiabetic, antiatherogenic, antioxidant, antitumor and estrogen-like properties. These diverse biological activities are largely related to the capacity of glabridin to down-regulate reactive oxygen species, bind to antioxidant effectors and act as a selective estrogen receptor modulator. On a molecular level it is, next to other targets, activating PPARgamma, inhibiting JNK1/2 and human carboxylesterase 2 (CES2A). Based on its antioxidant capacity it is also studied as an anti-aging cosmetic agent. Recently, it has been shown in docking experiments to have high binding affinity to the main protease of SARS-CoV-2.
- Smiles
- CC1(C)C=CC2=C(C=CC3=C2OC[C@@H](C4=C(O)C=C(O)C=C4)C3)O1
- InChi Key
- LBQIJVLKGVZRIW-ZDUSSCGKSA-N
- References
- (1) C. Simmler, et al., Fitoterapia 90, 160 (2013) , (2) L. Wang, et al., Acta. Pharmac. Sin. B 5, 310 (2015) , (3) K.J. Lee, et al., Evid.-Based Compl. Altern. Med. 2015, ID 165457 (2015) , (4) J.F. Rebhun, et al., Fitoterapia 106, 55 (2015) , (5) C.-T. Chen, et al., Environ. Toxicol. 33, 679 (2018) , (6) Y.-Q. Song, et al., Int. J. Biol. Macromol. 137, 261 (2019) , (7) P. Ciganovic, et al., Antioxidants 8, 445 (2019) , (8) Z.-F. Wang, et al., Curr. Med. Chem. 27, 1997 (2020) (Review) , (9) R. Islam, et al., J. Biomol. Struct. Dyn. (Epub ahead of Print) (2020) , (10) B. Goel, et al., Nat. Prod. Res. (Epub ahead of Print) (2020)
- InChi
- InChI=1S/C20H20O4/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22/h3-8,10,13,21-22H,9,11H2,1-2H3/t13-/m0/s1
Glabridin is a prenylated isoflavonoid found in licorice (Glycyrrhiza glabra L.) root extract that is reported to possess antiviral, antimicrobial, anti-inflammatory, antidiabetic, antiatherogenic, antioxidant, antitumor and estrogen-like properties. These diverse biological activities are largely related to the capacity of glabridin to down-regulate reactive oxygen species, bind to antioxidant effectors and act as a selective estrogen receptor modulator. On a molecular level it is, next to other targets, activating PPARgamma, inhibiting JNK1/2 and human carboxylesterase 2 (CES2A). Based on its antioxidant capacity it is also studied as an anti-aging cosmetic agent. Recently, it has been shown in docking experiments to have high binding affinity to the main protease of SARS-CoV-2.
Additional information
| Synonyms | (R)-4-(3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-yl)-1,3-benzenediol |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | White to light brown powder |
| CAS-Number | 59870-68-7 |
| Molecular Formula | C20H20O4 |
| Molecular Weight | 324.37 |
| Identity | 1H-NMR |
| Solvents | DMSO, ethanol, DMF (all 20 mg/ml) |
| Smiles | CC1(C)C=CC2=C(C=CC3=C2OC[C@@H](C4=C(O)C=C(O)C=C4)C3)O1 |
| InChi Key | LBQIJVLKGVZRIW-ZDUSSCGKSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | RT |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
| Transportation | Not dangerous goods |
| References | (1) C. Simmler, et al., Fitoterapia 90, 160 (2013), (2) L. Wang, et al., Acta. Pharmac. Sin. B 5, 310 (2015), (3) K.J. Lee, et al., Evid.-Based Compl. Altern. Med. 2015, ID 165457 (2015), (4) J.F. Rebhun, et al., Fitoterapia 106, 55 (2015), (5) C.-T. Chen, et al., Environ. Toxicol. 33, 679 (2018), (6) Y.-Q. Song, et al., Int. J. Biol. Macromol. 137, 261 (2019), (7) P. Ciganovic, et al., Antioxidants 8, 445 (2019), (8) Z.-F. Wang, et al., Curr. Med. Chem. 27, 1997 (2020) (Review), (9) R. Islam, et al., J. Biomol. Struct. Dyn. (Epub ahead of Print) (2020), (10) B. Goel, et al., Nat. Prod. Res. (Epub ahead of Print) (2020) |
| InChi | InChI=1S/C20H20O4/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22/h3-8,10,13,21-22H,9,11H2,1-2H3/t13-/m0/s1 |
| Quantity | 5 mg, 25 mg, Bulk |
