Specifications
- Purity
- ≥98% (HPLC)
- Identity
- 1H-NMR
- Appearance
- White solid
Properties
- Solvents
- DMSO (10 mg/ml), DMF (10 mg/ml)
Downloads
- Safety Data Sheet
- CDX G0208 MSDS.pdf
Available from stock
Glimepiride
- SKU
- G0208
Category: API's & Intermediates
- Synonyms
- trans-3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxyamide , Amaryl , HOE 490
- 93479-97-1
- CAS-Number
- C24H34N4O5S
- Molecular Formula
- 490.62
- Molecular Weight
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at RT.
- Long Term Storage
- RT
- Short Term Storage
- RT
- Shipping
- AMBIENT
- Transportation
- Not dangerous goods
- Signal word
- Warning
- GHS Symbol
- GHS08
- Precautionary statements
- P280
- Hazard statements
- H361
- Description
- Glimepiride is a long-acting sulfonylurea antidiabetic agent inhibiting ATP-sensitive potassium (KATP) channels in pancreatic β-cells, which leads to the release of insulin. In addition, Glimepiride increases the activity of intracellular insulin receptors. Studies conducted on adipocytes and skeletal muscle suggest that Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase and stimulates glucose transporter 1 and 4 (GLUT1/4) expression. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway and exhibits neuroprotective benefit, decreasing expression and activity of BACE1 and amyloid-β (Aβ) in neurons in a PPAR?-dependent manner.
- References
- (1) W. Kramer, et al., Horm. Metab. Res. 28, 464 (1996) , (2) G. Muller & K. Geisen, Horm. Metab. Res. 28, 469 (1996) , (3) D.K. Song & F.M. Ashcroft, Br. J. Pharmacol. 133, 193 (2001) , (4) M.L. Hribal, et al., Mol. Pharmacol. 59, 322 (2001) , (5) C.L. Lawrence, et al., Br. J. Pharmacol. 136, 746 (2002) , (6) K. Inukai, et al., BBRC 328, 484 (2005) , (7) P. Ma, et al., Metab. Clin. Exp. 59, 359 (2010) , (8) V.J. Briscoe, et al., Expert Opin. Drug Metab. Toxicol. 6, 225 (2010) , (9) F. Liu, et al., Neurosci. Lett. 557, 90 (2013)
- InChi Key
- WIGIZIANZCJQQY-RUCARUNLSA-N
- Smiles
- O=C1C(CC)=C(C)CN1C(NCCC2=CC=C(S(NC(N[C@H]3CC[C@H](C)CC3)=O)(=O)=O)C=C2)=O
Glimepiride is a long-acting sulfonylurea antidiabetic agent inhibiting ATP-sensitive potassium (KATP) channels in pancreatic β-cells, which leads to the release of insulin. In addition, Glimepiride increases the activity of intracellular insulin receptors. Studies conducted on adipocytes and skeletal muscle suggest that Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase and stimulates glucose transporter 1 and 4 (GLUT1/4) expression. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway and exhibits neuroprotective benefit, decreasing expression and activity of BACE1 and amyloid-β (Aβ) in neurons in a PPAR?-dependent manner.
Additional information
| Synonyms | trans-3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxyamide, Amaryl, HOE 490 |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | White solid |
| CAS-Number | 93479-97-1 |
| Molecular Formula | C24H34N4O5S |
| Molecular Weight | 490.62 |
| Identity | 1H-NMR |
| Solvents | DMSO (10 mg/ml), DMF (10 mg/ml) |
| Smiles | O=C1C(CC)=C(C)CN1C(NCCC2=CC=C(S(NC(N[C@H]3CC[C@H](C)CC3)=O)(=O)=O)C=C2)=O |
| InChi Key | WIGIZIANZCJQQY-RUCARUNLSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | RT |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
| Hazard statements | H361 |
| Precautionary statements | P280 |
| GHS Symbol | GHS08 |
| Signal word | Warning |
| Transportation | Not dangerous goods |
| References | (1) W. Kramer, et al., Horm. Metab. Res. 28, 464 (1996), (2) G. Muller & K. Geisen, Horm. Metab. Res. 28, 469 (1996), (3) D.K. Song & F.M. Ashcroft, Br. J. Pharmacol. 133, 193 (2001), (4) M.L. Hribal, et al., Mol. Pharmacol. 59, 322 (2001), (5) C.L. Lawrence, et al., Br. J. Pharmacol. 136, 746 (2002), (6) K. Inukai, et al., BBRC 328, 484 (2005), (7) P. Ma, et al., Metab. Clin. Exp. 59, 359 (2010), (8) V.J. Briscoe, et al., Expert Opin. Drug Metab. Toxicol. 6, 225 (2010), (9) F. Liu, et al., Neurosci. Lett. 557, 90 (2013) |
| Quantity | 250 mg, 1 g, Bulk |
