Available from stock

Glimepiride

SKU: G0208

Category: API's & Intermediates

Synonyms: trans-3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxyamide , Amaryl , HOE 490; 93479-97-1
CAS-Number: C₂₄H₃₄N₄O₅S
Molecular Formula: 490.62
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: White solid
Identity: 1H-NMR

Properties

Solvents: DMSO (10 mg/ml), DMF (10 mg/ml)

Documentation

Safety Data Sheet (SDS): CDX G0208 MSDS.pdf

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: RT
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at RT.

Hazard statements: H361
Precautionary statements: P280
GHS Symbol: GHS08
Signal word: Warning
Transportation: Not dangerous goods

Description: Glimepiride is a long-acting sulfonylurea antidiabetic agent inhibiting ATP-sensitive potassium (KATP) channels in pancreatic β-cells, which leads to the release of insulin. In addition, Glimepiride increases the activity of intracellular insulin receptors. Studies conducted on adipocytes and skeletal muscle suggest that Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase and stimulates glucose transporter 1 and 4 (GLUT1/4) expression. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway and exhibits neuroprotective benefit, decreasing expression and activity of BACE1 and amyloid-β (Aβ) in neurons in a PPAR?-dependent manner.
Smiles: O=C1C(CC)=C(C)CN1C(NCCC2=CC=C(S(NC(N[C@H]3CC[C@H](C)CC3)=O)(=O)=O)C=C2)=O
InChi Key: WIGIZIANZCJQQY-RUCARUNLSA-N
References: (1) W. Kramer, et al., Horm. Metab. Res. 28, 464 (1996) , (2) G. Muller & K. Geisen, Horm. Metab. Res. 28, 469 (1996) , (3) D.K. Song & F.M. Ashcroft, Br. J. Pharmacol. 133, 193 (2001) , (4) M.L. Hribal, et al., Mol. Pharmacol. 59, 322 (2001) , (5) C.L. Lawrence, et al., Br. J. Pharmacol. 136, 746 (2002) , (6) K. Inukai, et al., BBRC 328, 484 (2005) , (7) P. Ma, et al., Metab. Clin. Exp. 59, 359 (2010) , (8) V.J. Briscoe, et al., Expert Opin. Drug Metab. Toxicol. 6, 225 (2010) , (9) F. Liu, et al., Neurosci. Lett. 557, 90 (2013)

Glimepiride is a long-acting sulfonylurea antidiabetic agent inhibiting ATP-sensitive potassium (KATP) channels in pancreatic β-cells, which leads to the release of insulin. In addition, Glimepiride increases the activity of intracellular insulin receptors. Studies conducted on adipocytes and skeletal muscle suggest that Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase and stimulates glucose transporter 1 and 4 (GLUT1/4) expression. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway and exhibits neuroprotective benefit, decreasing expression and activity of BACE1 and amyloid-β (Aβ) in neurons in a PPAR?-dependent manner.

SKU: G0208 Category: API's & Intermediates

Additional information

Additional information

Synonyms	trans-3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxyamide, Amaryl, HOE 490
Purity	≥98% (HPLC)
Appearance	White solid
CAS-Number	93479-97-1
Molecular Formula	C24H34N4O5S
Molecular Weight	490.62
Identity	1H-NMR
Solvents	DMSO (10 mg/ml), DMF (10 mg/ml)
Smiles	O=C1C(CC)=C(C)CN1C(NCCC2=CC=C(S(NC(N[C@H]3CC[C@H](C)CC3)=O)(=O)=O)C=C2)=O
InChi Key	WIGIZIANZCJQQY-RUCARUNLSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	RT
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at RT.
Hazard statements	H361
Precautionary statements	P280
GHS Symbol	GHS08
Signal word	Warning
Transportation	Not dangerous goods
References	(1) W. Kramer, et al., Horm. Metab. Res. 28, 464 (1996), (2) G. Muller & K. Geisen, Horm. Metab. Res. 28, 469 (1996), (3) D.K. Song & F.M. Ashcroft, Br. J. Pharmacol. 133, 193 (2001), (4) M.L. Hribal, et al., Mol. Pharmacol. 59, 322 (2001), (5) C.L. Lawrence, et al., Br. J. Pharmacol. 136, 746 (2002), (6) K. Inukai, et al., BBRC 328, 484 (2005), (7) P. Ma, et al., Metab. Clin. Exp. 59, 359 (2010), (8) V.J. Briscoe, et al., Expert Opin. Drug Metab. Toxicol. 6, 225 (2010), (9) F. Liu, et al., Neurosci. Lett. 557, 90 (2013)
Quantity	250 mg, 1 g, Bulk