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    Glimepiride

    Available from stock

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      Glimepiride

      SKU
      G0208

      Category: API's & Intermediates

      Synonyms
      trans-3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxyamide , Amaryl , HOE 490
      93479-97-1
      CAS-Number
      C24H34N4O5S
      Molecular Formula
      490.62
      Molecular Weight

      For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥98% (HPLC)
      Appearance
      White solid
      Identity
      1H-NMR

      Properties

      Solvents
      DMSO (10 mg/ml), DMF (10 mg/ml)

      Documentation

      Safety Data Sheet (SDS)
      CDX G0208 MSDS.pdf
      Shipping
      AMBIENT
      Short Term Storage
      RT
      Long Term Storage
      RT
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at RT.
      Hazard statements
      H361
      Precautionary statements
      P280
      GHS Symbol
      GHS08
      Signal word
      Warning
      Transportation
      Not dangerous goods
      Description
      Glimepiride is a long-acting sulfonylurea antidiabetic agent inhibiting ATP-sensitive potassium (KATP) channels in pancreatic β-cells, which leads to the release of insulin. In addition, Glimepiride increases the activity of intracellular insulin receptors. Studies conducted on adipocytes and skeletal muscle suggest that Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase and stimulates glucose transporter 1 and 4 (GLUT1/4) expression. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway and exhibits neuroprotective benefit, decreasing expression and activity of BACE1 and amyloid-β (Aβ) in neurons in a PPAR?-dependent manner.
      Smiles
      O=C1C(CC)=C(C)CN1C(NCCC2=CC=C(S(NC(N[C@H]3CC[C@H](C)CC3)=O)(=O)=O)C=C2)=O
      InChi Key
      WIGIZIANZCJQQY-RUCARUNLSA-N
      References
      (1) W. Kramer, et al., Horm. Metab. Res. 28, 464 (1996) , (2) G. Muller & K. Geisen, Horm. Metab. Res. 28, 469 (1996) , (3) D.K. Song & F.M. Ashcroft, Br. J. Pharmacol. 133, 193 (2001) , (4) M.L. Hribal, et al., Mol. Pharmacol. 59, 322 (2001) , (5) C.L. Lawrence, et al., Br. J. Pharmacol. 136, 746 (2002) , (6) K. Inukai, et al., BBRC 328, 484 (2005) , (7) P. Ma, et al., Metab. Clin. Exp. 59, 359 (2010) , (8) V.J. Briscoe, et al., Expert Opin. Drug Metab. Toxicol. 6, 225 (2010) , (9) F. Liu, et al., Neurosci. Lett. 557, 90 (2013)

      Glimepiride is a long-acting sulfonylurea antidiabetic agent inhibiting ATP-sensitive potassium (KATP) channels in pancreatic β-cells, which leads to the release of insulin. In addition, Glimepiride increases the activity of intracellular insulin receptors. Studies conducted on adipocytes and skeletal muscle suggest that Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase and stimulates glucose transporter 1 and 4 (GLUT1/4) expression. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway and exhibits neuroprotective benefit, decreasing expression and activity of BACE1 and amyloid-β (Aβ) in neurons in a PPAR?-dependent manner.

      SKU: G0208 Category: API's & Intermediates
      • Additional information

      Additional information

      Synonyms

      trans-3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxyamide, Amaryl, HOE 490

      Purity

      ≥98% (HPLC)

      Appearance

      White solid

      CAS-Number

      93479-97-1

      Molecular Formula

      C24H34N4O5S

      Molecular Weight

      490.62

      Identity

      1H-NMR

      Solvents

      DMSO (10 mg/ml), DMF (10 mg/ml)

      Smiles

      O=C1C(CC)=C(C)CN1C(NCCC2=CC=C(S(NC(N[C@H]3CC[C@H](C)CC3)=O)(=O)=O)C=C2)=O

      InChi Key

      WIGIZIANZCJQQY-RUCARUNLSA-N

      Shipping

      AMBIENT

      Short Term Storage

      RT

      Long Term Storage

      RT

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at RT.

      Hazard statements

      H361

      Precautionary statements

      P280

      GHS Symbol

      GHS08

      Signal word

      Warning

      Transportation

      Not dangerous goods

      References

      (1) W. Kramer, et al., Horm. Metab. Res. 28, 464 (1996), (2) G. Muller & K. Geisen, Horm. Metab. Res. 28, 469 (1996), (3) D.K. Song & F.M. Ashcroft, Br. J. Pharmacol. 133, 193 (2001), (4) M.L. Hribal, et al., Mol. Pharmacol. 59, 322 (2001), (5) C.L. Lawrence, et al., Br. J. Pharmacol. 136, 746 (2002), (6) K. Inukai, et al., BBRC 328, 484 (2005), (7) P. Ma, et al., Metab. Clin. Exp. 59, 359 (2010), (8) V.J. Briscoe, et al., Expert Opin. Drug Metab. Toxicol. 6, 225 (2010), (9) F. Liu, et al., Neurosci. Lett. 557, 90 (2013)

      Quantity

      250 mg, 1 g, Bulk

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