Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White powder
- Identity
- 1H-NMR
Properties
- Solvents
- water
- Melting Point
- 171-175°C
Available from stock
Glucuronolactone
- SKU
- G0044
Category: Carbohydrates
- Synonyms
- D-(+)-Glucuronic acid γ , -lactone , D-(+)-Glucurono-6,3-lactone , D-Glucurono-6,3-lactone , D-Glucurone
- 32449-92-6
- CAS-Number
- C6H8O6_x000D_
- Molecular Formula
- 176.12
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- RT
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at RT.
- Transportation
- Not dangerous goods
- Description
- Naturally occurring carbohydrate derivative that is an important structural component of nearly all connective tissues and is also found in many plant gums. Metabolized to glucaric acid, xylitol, and L-xylulose, and humans may also be able to use glucuronolactone as a precursor for ascorbic acid synthesis. Used as a detoxicant. The liver uses glucose to create glucuronolactone, which inhibits the enzyme B-glucuronidase (metabolizes glucuronides), which should cause blood-glucuronide levels to rise. Glucuronides combine with toxic substances, such as morphine and depot medroxyprogesterone acetate, by converting them to water-soluble glucuronide-conjugates which are excreted in the urine. Used as building block and starting reagent for synthesis of drugs, optically active glucopyranoses and long-chain alkyl glucofuranosides.
- Smiles
- O[C@@H]1[C@@H](OC2=O)[C@@H]([C@@H]2O)OC1O
- InChi Key
- OGLCQHRZUSEXNB-VGASXLIASA-N
- References
- C.A. Marsh, Biochem. J. 99, 22 (1966) , S.H. Kim, et al., Acta Crystallogr. 22, 733 (1967) , L. Trahan, et al., Rev. Can. Biol. 29, 7 (1970) , T. Kuzuya, et al., Endocrinol. Jpn. 20, 369 (1973) , A. Kirschning, et al., Bioorg. Med. Chem. Lett. 7, 903 (1997) , S. Suzuki, et al., J. Chromatogr. Sci. 36, 357 (1998) , A.F. Glawar, et al., Chemistry 18, 9341 (2012)
- InChi
- InChI=1S/C6H8O6/c7-1-3-4(12-5(1)9)2(8)6(10)11-3/h1-5,7-9H/t1-,2+,3-,4-,5?/m1/s1
Naturally occurring carbohydrate derivative that is an important structural component of nearly all connective tissues and is also found in many plant gums. Metabolized to glucaric acid, xylitol, and L-xylulose, and humans may also be able to use glucuronolactone as a precursor for ascorbic acid synthesis. Used as a detoxicant. The liver uses glucose to create glucuronolactone, which inhibits the enzyme B-glucuronidase (metabolizes glucuronides), which should cause blood-glucuronide levels to rise. Glucuronides combine with toxic substances, such as morphine and depot medroxyprogesterone acetate, by converting them to water-soluble glucuronide-conjugates which are excreted in the urine. Used as building block and starting reagent for synthesis of drugs, optically active glucopyranoses and long-chain alkyl glucofuranosides.
Additional information
| Synonyms | D-(+)-Glucuronic acid γ, -lactone, D-(+)-Glucurono-6,3-lactone, D-Glucurono-6,3-lactone, D-Glucurone |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | White powder |
| CAS-Number | 32449-92-6 |
| Molecular Formula | C6H8O6_x000D_ |
| Molecular Weight | 176.12 |
| Identity | 1H-NMR |
| Solvents | water |
| Melting Point | 171-175°C |
| Smiles | O[C@@H]1[C@@H](OC2=O)[C@@H]([C@@H]2O)OC1O |
| InChi Key | OGLCQHRZUSEXNB-VGASXLIASA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | RT |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
| Transportation | Not dangerous goods |
| References | C.A. Marsh, Biochem. J. 99, 22 (1966), S.H. Kim, et al., Acta Crystallogr. 22, 733 (1967), L. Trahan, et al., Rev. Can. Biol. 29, 7 (1970), T. Kuzuya, et al., Endocrinol. Jpn. 20, 369 (1973), A. Kirschning, et al., Bioorg. Med. Chem. Lett. 7, 903 (1997), S. Suzuki, et al., J. Chromatogr. Sci. 36, 357 (1998), A.F. Glawar, et al., Chemistry 18, 9341 (2012) |
| InChi | InChI=1S/C6H8O6/c7-1-3-4(12-5(1)9)2(8)6(10)11-3/h1-5,7-9H/t1-,2+,3-,4-,5?/m1/s1 |
| Quantity | 25 g, 250 g, 500 g, Bulk |
