Specifications
- Purity
- ≥90% (TLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- water, DMSO
Documentation
- Safety Data Sheet (SDS)
- CDX G0006 MSDS_V1.2.pdf
Available from stock
GSH-OEt
- SKU
- G0006
Category: Amino Acids, Peptides, Proteins
- Synonyms
- Glutathione reduced ethyl ester , γ-Glu-Cys-Gly-OEt , GSH-MEE
- 92614-59-0
- CAS-Number
- C12H21N3O6S
- Molecular Formula
- 335.38
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- +4°C
- Long Term Storage
- -20°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Transportation
- Not dangerous goods
- Description
- GSH-OEt is cellpermeable and has been used to protect cells against radiation damage, oxidants and various toxic compounds including heavy metals. GSH-OEt is a protective agent against cellular damage, such as cataracts and mitochondrial degeneration. It undergoes hydrolysis by intracellular esterases thereby increasing intracellular GSH concentration in many tissues and cell types. Glutathione monoethyl ester may be used to supplement cellular pools of GSH in vitro and in vivo and can prevent ROS formation, neutralize toxic products and block apoptosis pathway. The effect of glutathione (GSH) and glutathione ethyl ester (GSH-OEt) supplementation on GSH homeostasis and exercise-induced oxidative stress was also examined. Glutathione ethyl ester protects against cisplatin-induced ototoxicity in the rat.
- Smiles
- CCOC(=O)CNC(=O)[C@H](CS)NC(=O)CC[C@H](N)C(O)=O
- InChi Key
- JKRODHBGNBKZLE-YUMQZZPRSA-N
- References
- (1) M. A. Retamal et al.: PNAS, 103(12), 4475 (2006) , (2) C. Leeuwenburgh et al.: J. Nutr. 128(12), 2420 (1998) , (3) K.Nishida et al.: Res. Commun. Chem. Pathol. Pharmacol. 82, 49 (1993)
- InChi
- InChI=1S/C12H21N3O6S/c1-2-21-10(17)5-14-11(18)8(6-22)15-9(16)4-3-7(13)12(19)20/h7-8,22H,2-6,13H2,1H3,(H,14,18)(H,15,16)(H,19,20)/t7-,8-/m0/s1
GSH-OEt is cellpermeable and has been used to protect cells against radiation damage, oxidants and various toxic compounds including heavy metals. GSH-OEt is a protective agent against cellular damage, such as cataracts and mitochondrial degeneration. It undergoes hydrolysis by intracellular esterases thereby increasing intracellular GSH concentration in many tissues and cell types. Glutathione monoethyl ester may be used to supplement cellular pools of GSH in vitro and in vivo and can prevent ROS formation, neutralize toxic products and block apoptosis pathway. The effect of glutathione (GSH) and glutathione ethyl ester (GSH-OEt) supplementation on GSH homeostasis and exercise-induced oxidative stress was also examined. Glutathione ethyl ester protects against cisplatin-induced ototoxicity in the rat.
Additional information
| Synonyms | Glutathione reduced ethyl ester, γ-Glu-Cys-Gly-OEt, GSH-MEE |
|---|---|
| Purity | ≥90% (TLC) |
| Appearance | White to off-white powder |
| CAS-Number | 92614-59-0 |
| Molecular Formula | C12H21N3O6S |
| Molecular Weight | 335.38 |
| Identity | 1H-NMR |
| Solvents | water, DMSO |
| Smiles | CCOC(=O)CNC(=O)[C@H](CS)NC(=O)CC[C@H](N)C(O)=O |
| InChi Key | JKRODHBGNBKZLE-YUMQZZPRSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Transportation | Not dangerous goods |
| References | (1) M. A. Retamal et al.: PNAS, 103(12), 4475 (2006), (2) C. Leeuwenburgh et al.: J. Nutr. 128(12), 2420 (1998), (3) K.Nishida et al.: Res. Commun. Chem. Pathol. Pharmacol. 82, 49 (1993) |
| InChi | InChI=1S/C12H21N3O6S/c1-2-21-10(17)5-14-11(18)8(6-22)15-9(16)4-3-7(13)12(19)20/h7-8,22H,2-6,13H2,1H3,(H,14,18)(H,15,16)(H,19,20)/t7-,8-/m0/s1 |
| Quantity | 100 mg, 500 mg, 5 g, Bulk |
