Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- Yellow liquid
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO
Documentation
- Safety Data Sheet (SDS)
- CDX H0155 MSDS.pdf
Available from stock
Hydroxytyrosol
- SKU
- H0155
Category: Phytochemicals
- Synonyms
- 3-Hydroxytyrosol , 2-(3,4-Dihydroxyphenyl)ethanol , 3,4-Dihydroxyphenethyl alcohol , DOPET , 3,4-DHPEA , Ba2774
- 10597-60-1
- CAS-Number
- C8H10O3
- Molecular Formula
- 154.16
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- +4°C
- Long Term Storage
- -20°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Hazard statements
- H315-H319-H335
- Precautionary statements
- P261-P305 + P351 + P338
- GHS Symbol
- GHS07
- Transportation
- Not dangerous goods
- Description
- Phenolic component of olive oil. Metabolite of oleuropein. Antioxidant that inhibits both 12- and 5-lipoxygenase (LO) activity. The IC50 values for the inhibition of rat platelet 12-LO and rat neutrophil 5-LO are 4.2 and 13µM, respectively. It does not inhibit, and may actually enhance, COX activity. Protects LDL from both biological and chemical oxidation, suggesting a potential mechanism for the protective effects of olive oil against atherosclerosis. Inhibits the rate of cancer cell proliferation and induces cancer cell apoptosis. Also described to induce growth arrest and apoptosis in human colon carcinoma HT-29 cells through activation of the serine/threonine protein phosphatase 2A. Protects ?-Cells from amylin amyloid-Induced cytotoxicity.
- Smiles
- OC1=CC=C(CCO)C=C1O
- InChi Key
- JUUBCHWRXWPFFH-UHFFFAOYSA-N
- References
- (1) N. Kohyama, et al., Biosci. Biotechnol. Biochem. 61, 347 (1997) , (2) P. Grignaffini, et al., Lancet 343, 1296 (1994) , (3) C. Manna, et al., J. Nutr. 127, 286 (1997) , (4) C.A. Palmerini, et al., J. Nutr. Biochem. 16, 109 (2005) , (5) C. Guichard, et al., Carcinogenesis 27, 1812 (2006) , (6) L. Wu, et al., Biochemistry 56, 5035 (2017)
Phenolic component of olive oil. Metabolite of oleuropein. Antioxidant that inhibits both 12- and 5-lipoxygenase (LO) activity. The IC50 values for the inhibition of rat platelet 12-LO and rat neutrophil 5-LO are 4.2 and 13µM, respectively. It does not inhibit, and may actually enhance, COX activity. Protects LDL from both biological and chemical oxidation, suggesting a potential mechanism for the protective effects of olive oil against atherosclerosis. Inhibits the rate of cancer cell proliferation and induces cancer cell apoptosis. Also described to induce growth arrest and apoptosis in human colon carcinoma HT-29 cells through activation of the serine/threonine protein phosphatase 2A. Protects ?-Cells from amylin amyloid-Induced cytotoxicity.
Additional information
| Synonyms | 3-Hydroxytyrosol, 2-(3,4-Dihydroxyphenyl)ethanol, 3,4-Dihydroxyphenethyl alcohol, DOPET, 3,4-DHPEA, Ba2774 |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | Yellow liquid |
| CAS-Number | 10597-60-1 |
| Molecular Formula | C8H10O3 |
| Molecular Weight | 154.16 |
| Identity | 1H-NMR |
| Solvents | DMSO |
| Smiles | OC1=CC=C(CCO)C=C1O |
| InChi Key | JUUBCHWRXWPFFH-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305 + P351 + P338 |
| GHS Symbol | GHS07 |
| Transportation | Not dangerous goods |
| References | (1) N. Kohyama, et al., Biosci. Biotechnol. Biochem. 61, 347 (1997), (2) P. Grignaffini, et al., Lancet 343, 1296 (1994), (3) C. Manna, et al., J. Nutr. 127, 286 (1997), (4) C.A. Palmerini, et al., J. Nutr. Biochem. 16, 109 (2005), (5) C. Guichard, et al., Carcinogenesis 27, 1812 (2006), (6) L. Wu, et al., Biochemistry 56, 5035 (2017) |
| Quantity | 25 mg, 100 mg, Bulk |
