Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (20 mg/ml), DMF (30 mg/ml), ethanol (20 mg/ml)
Category: Lipids, Fatty Acids
Hyodeoxycholic acid is a secondary bile acid. It is produced from lithocholic acid by bacterial action in the colon. Dietary supplementation with HDCA results in decreased plasma VLDL and LDL cholesterol and reduced atherosclerosis in mice. Serum levels of HDCA are increased significantly in Crohn’s disease and ulcerative colitis. Hyodeoxycholic acid can be used as a building block/ precursor for steroid synthesis.
Synonyms | HDCA, 3α,6α-Dihydroxy-5β-cholan-24-oic acid, NSC 60672, BRN 3218394, Iodeoxycholic acid |
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Purity | ≥98% (HPLC) |
Appearance | White powder |
CAS-Number | 83-49-8 |
Molecular Formula | C24H40O4 |
Molecular Weight | 392.57 |
Identity | 1H-NMR |
Solvents | DMSO (20 mg/ml), DMF (30 mg/ml), ethanol (20 mg/ml) |
Smiles | O[C@@H]1CC[C@@]2(C)[C@@]([C@@H](O)C[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@@H](CCC(O)=O)C)([H])C1 |
InChi Key | DGABKXLVXPYZII-SIBKNCMHSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Transportation | Not dangerous goods |
References | (1) W.Z. Chow & D.C. Huang, Sci. Sin. 14, 1083 (1965), (2) K. Einarsson, J. Biol. Chem. 241, 534 (1966), (3) K. Ochi, et al., Steroids 30, 795 (1977), (4) K.R. Bharucha, Steroids 32, 589 (1978), (5) C.K. McSherry, et al., Am. J. Surg. 149, 126 (1985), (6) E. Sehayek, et al., J. Lipid Res. 42, 1250 (2001), (7) C. Gnewuch, et al., World J. Gastroenterol. 15, 3134 (2009), (8) D.M. Shih, et al., FASEB J. 27, 3805 (2013), (9) S. Watanabe & K. Fujita, Lipids 49, 963 (2014) |
InChi | InChI=1S/C24H40O4/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16+,17-,18+,19+,20+,21+,23-,24-/m1/s1 |
Quantity | 10 g, Bulk |