Available from stock

Icariin

SKU: I0172

Category: Phytochemicals

Synonyms: 4'-O-Methyl-8-γ,γ-dimethylallylkaempferol-3-rhamnoside-7-glucoside , Ieariline; 489-32-7
CAS-Number: C₃₃H₄₀O₁₅
Molecular Formula: 676.668
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥97% (HPLC)
Appearance: Light yellow fine powder
Identity: 1H-NMR

Properties

Solvents: DMSO (20 mg/ml), DMF (20 mg/ml)

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: -20°C
Handling Advice: Protect from light and air.
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.

Transportation: Not dangerous goods

Description: Icariin, the active component of the Chinese medicinal plant E. brevicornum. It has been shown to have anti-inflammatory, anticancer, antioxidant, osteoprotective, neuroprotective and cardioprotective activity. It has been shown to enhance bone formation and bone regeneration. Icariin may be beneficial to Alzheimer's disease by reducing the production of extracellular amyloid plaques and intracellular neurofibrillary tangles and inhibiting phosphodiesterase-5 activity. The anti-cancer activity is related to various mechanisms such as apoptosis and autophagy induction, cell cycle modulation, antiangiogenesis and antimetastasis, modulating multidrug resistance and immunomodulation. Icariin interacts with several pathways, like PDE, TGF-ß, MAPK, PPAR, NOS, IGF, Sirtuin and others. Icariin has been shown to inhibit the NF-?B activation pathway and NLRP3 inflammasome.
Smiles: O=C1C2=C(O)C=C(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)C(C/C=C(C)/C)=C2OC(C4=CC=C(OC)C=C4)=C1O[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5
InChi Key: TZJALUIVHRYQQB-XLRXWWTNSA-N
References: (1) L.G. Ming, et al., J. Cell Physiol. 228, 513 (2013) (Review) , (2) J.K. Schluesener & H. Schluesener, Mol. Nutr. Food Res. 58, 49 (2014) (Review) , (3) H.L. Tan, et al., Front. Pharmacol. 7, 191 (2016 (Review) , (4) R. Shen & J.H. Wang, Am. J. Clin. Exp. Immunol. 7, 50 (2018) (Review) , (5) B. Su, et al., Life Sci. 208, 26 (2018) , (6) J. Jin, et al., Eur. J. Pharmacol. 842, 20 (2019) (Review) , (7) C. Angeloni, et al., Front. Pharmacol. 10, 271 (2019) (Review) , (8) A. Yang, et al., Stem Cells Int. 2019, 5747298 (2019) (Review)
InChi: InChI=1S/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3/t14-,20+,22-,23+,25+,26-,27+,28+,32-,33+/m0/s1

Icariin, the active component of the Chinese medicinal plant E. brevicornum. It has been shown to have anti-inflammatory, anticancer, antioxidant, osteoprotective, neuroprotective and cardioprotective activity. It has been shown to enhance bone formation and bone regeneration. Icariin may be beneficial to Alzheimer’s disease by reducing the production of extracellular amyloid plaques and intracellular neurofibrillary tangles and inhibiting phosphodiesterase-5 activity. The anti-cancer activity is related to various mechanisms such as apoptosis and autophagy induction, cell cycle modulation, antiangiogenesis and antimetastasis, modulating multidrug resistance and immunomodulation. Icariin interacts with several pathways, like PDE, TGF-ß, MAPK, PPAR, NOS, IGF, Sirtuin and others. Icariin has been shown to inhibit the NF-?B activation pathway and NLRP3 inflammasome.

SKU: I0172 Category: Phytochemicals

Additional information

Additional information

Synonyms	4'-O-Methyl-8-γ,γ-dimethylallylkaempferol-3-rhamnoside-7-glucoside, Ieariline
Purity	≥97% (HPLC)
Appearance	Light yellow fine powder
CAS-Number	489-32-7
Molecular Formula	C33H40O15
Molecular Weight	676.668
Identity	1H-NMR
Solvents	DMSO (20 mg/ml), DMF (20 mg/ml)
Smiles	O=C1C2=C(O)C=C(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)C(C/C=C(C)/C)=C2OC(C4=CC=C(OC)C=C4)=C1O[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5
InChi Key	TZJALUIVHRYQQB-XLRXWWTNSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	-20°C
Handling Advice	Protect from light and air.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Transportation	Not dangerous goods
References	(1) L.G. Ming, et al., J. Cell Physiol. 228, 513 (2013) (Review), (2) J.K. Schluesener & H. Schluesener, Mol. Nutr. Food Res. 58, 49 (2014) (Review), (3) H.L. Tan, et al., Front. Pharmacol. 7, 191 (2016 (Review), (4) R. Shen & J.H. Wang, Am. J. Clin. Exp. Immunol. 7, 50 (2018) (Review), (5) B. Su, et al., Life Sci. 208, 26 (2018), (6) J. Jin, et al., Eur. J. Pharmacol. 842, 20 (2019) (Review), (7) C. Angeloni, et al., Front. Pharmacol. 10, 271 (2019) (Review), (8) A. Yang, et al., Stem Cells Int. 2019, 5747298 (2019) (Review)
InChi	InChI=1S/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3/t14-,20+,22-,23+,25+,26-,27+,28+,32-,33+/m0/s1
Quantity	100 mg, Bulk