Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- Yellow powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (15 mg/ml), DMF (15 mg/ml), methanol (5 mg/ml)
Available from stock
Isoorientin
- SKU
- I0095
Category: Carbohydrates
- Synonyms
- Homoorientin , Luteolin 6-C-β-D-glucoside , Luteolin 6-C-glucoside , Lespecapitioside
- 4261-42-1
- CAS-Number
- C21H20O11
- Molecular Formula
- 448.38
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- +4°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at +4°C.
- Transportation
- Not dangerous goods
- Description
- Isoorientin is a flavonoid with various biological properties. It has anticancer, antioxidant, anti-inflammatory, antimicrobial, gastroprotective and antinociceptive activities. It induces apoptosis in and reduces cell viability of cancer cells. It is a selective Cyclooxygenase-2 (COX-2) inhibitor. Reduces expression of COX-2, IL-6, 5-lipoxygenase (5-LO), and TNF-α in RAW 264.7 cells. It also has shown to regulate lipid metabolism.
- Smiles
- OC(C(C(C=C(C1=CC(O)=C(O)C=C1)O2)=O)=C2C=C3O)=C3[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4
- InChi Key
- ODBRNZZJSYPIDI-VJXVFPJBSA-N
- References
- (1) M. Sumalatha, et al., Nat. Prod. Commun. 10, 1703 (2015) , (2) L. Yuan, et al., J. Agric. Food Chem. 64, 2682 (2016) , (3) X. Lin, et al., J. Ethnopharmacol. 187, 187 (2016) , (4) L. Yuan, et al., Biomed. Pharmacother. 81, 356 (2016) , (5) T. Ye, et al., Onco. Targets Ther. 9, 7481 (2016) , (6) K. Anilkumar, et al., Oxid. Med. Cell. Longev. 2017, 5498054 (2017) , (7) E.S. Karaoglan, et al., Acta. Cir. Bras. 33, 609 (2018) , (8) L. Yuan, et al., J. Agric. Food Chem. 66, 9777 (2018) , (9) G. Zhang, et al., Int. Immunopharmacol. 75, 105753 (2019)
Isoorientin is a flavonoid with various biological properties. It has anticancer, antioxidant, anti-inflammatory, antimicrobial, gastroprotective and antinociceptive activities. It induces apoptosis in and reduces cell viability of cancer cells. It is a selective Cyclooxygenase-2 (COX-2) inhibitor. Reduces expression of COX-2, IL-6, 5-lipoxygenase (5-LO), and TNF-α in RAW 264.7 cells. It also has shown to regulate lipid metabolism.
Additional information
| Synonyms | Homoorientin, Luteolin 6-C-β-D-glucoside, Luteolin 6-C-glucoside, Lespecapitioside |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | Yellow powder |
| CAS-Number | 4261-42-1 |
| Molecular Formula | C21H20O11 |
| Molecular Weight | 448.38 |
| Identity | 1H-NMR |
| Solvents | DMSO (15 mg/ml), DMF (15 mg/ml), methanol (5 mg/ml) |
| Smiles | OC(C(C(C=C(C1=CC(O)=C(O)C=C1)O2)=O)=C2C=C3O)=C3[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4 |
| InChi Key | ODBRNZZJSYPIDI-VJXVFPJBSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Transportation | Not dangerous goods |
| References | (1) M. Sumalatha, et al., Nat. Prod. Commun. 10, 1703 (2015), (2) L. Yuan, et al., J. Agric. Food Chem. 64, 2682 (2016), (3) X. Lin, et al., J. Ethnopharmacol. 187, 187 (2016), (4) L. Yuan, et al., Biomed. Pharmacother. 81, 356 (2016), (5) T. Ye, et al., Onco. Targets Ther. 9, 7481 (2016), (6) K. Anilkumar, et al., Oxid. Med. Cell. Longev. 2017, 5498054 (2017), (7) E.S. Karaoglan, et al., Acta. Cir. Bras. 33, 609 (2018), (8) L. Yuan, et al., J. Agric. Food Chem. 66, 9777 (2018), (9) G. Zhang, et al., Int. Immunopharmacol. 75, 105753 (2019) |
| Quantity | 1 mg, 5 mg, 10 mg, Bulk |
