Specifications
- Purity
- ≥90% (HPLC)
- Appearance
- Dark violet powder
- Identity
- 1H-NMR
Properties
- Solvents
- methanol, DMSO
- Fluorescence
- λex 505 nm, λem 597 nm
Documentation
- Safety Data Sheet (SDS)
- CDX T0046 MSDS.pdf
Available from stock
JC-1
- SKU
- T0046
Categories: Fluorescent Detection, Fluorescent Detection
- Synonyms
- JC-1 jodide
- 3520-43-2
- CAS-Number
- C25H27Cl4IN4
- Molecular Formula
- 652.23
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- +4°C
- Long Term Storage
- -20°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Transportation
- Not dangerous goods
- Description
- A dual-emission potential-sensitive probe that can be used to measure mitochondrial membrane potential. JC-1 is a green-fluorescent monomer at low membrane potential. At higher potentials, JC-1 forms red-fluorescent J-aggregates, which exhibit broad excitation and very narrow emission spectra. The ratio of red to green fluorescence of JC-1 is dependent only on membrane potential, and not influenced by mitochondrial size, shape, or density.
- Smiles
- [I-].CCN1C(=CC=CC2=[N+](CC)C3=C(C=C(Cl)C(Cl)=C3)N2CC)N(CC)C2=C1C=C(Cl)C(Cl)=C2
- InChi Key
- FYNNIUVBDKICAX-UHFFFAOYSA-M
- References
- (1) G.Y. Guralchuk et al.: J. Phys. Chem. C 112(38), 14762 (2008) , (2) S.T. Smiley et al.: PNAS 88, 3671 (1991) , (3) M. Reers, et al.: Biochem. 30, 4480 (1991)
- InChi
- InChI=1S/C25H27Cl4N4.HI/c1-5-30-20-12-16(26)17(27)13-21(20)31(6-2)24(30)10-9-11-25-32(7-3)22-14-18(28)19(29)15-23(22)33(25)8-4
A dual-emission potential-sensitive probe that can be used to measure mitochondrial membrane potential. JC-1 is a green-fluorescent monomer at low membrane potential. At higher potentials, JC-1 forms red-fluorescent J-aggregates, which exhibit broad excitation and very narrow emission spectra. The ratio of red to green fluorescence of JC-1 is dependent only on membrane potential, and not influenced by mitochondrial size, shape, or density.
Additional information
| Synonyms | JC-1 jodide |
|---|---|
| Purity | ≥90% (HPLC) |
| Appearance | Dark violet powder |
| CAS-Number | 3520-43-2 |
| Molecular Formula | C25H27Cl4IN4 |
| Molecular Weight | 652.23 |
| Identity | 1H-NMR |
| Solvents | methanol, DMSO |
| Fluorescence | λex 505 nm, λem 597 nm |
| Smiles | [I-].CCN1C(=CC=CC2=[N+](CC)C3=C(C=C(Cl)C(Cl)=C3)N2CC)N(CC)C2=C1C=C(Cl)C(Cl)=C2 |
| InChi Key | FYNNIUVBDKICAX-UHFFFAOYSA-M |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Transportation | Not dangerous goods |
| References | (1) G.Y. Guralchuk et al.: J. Phys. Chem. C 112(38), 14762 (2008), (2) S.T. Smiley et al.: PNAS 88, 3671 (1991), (3) M. Reers, et al.: Biochem. 30, 4480 (1991) |
| InChi | InChI=1S/C25H27Cl4N4.HI/c1-5-30-20-12-16(26)17(27)13-21(20)31(6-2)24(30)10-9-11-25-32(7-3)22-14-18(28)19(29)15-23(22)33(25)8-4 |
| Quantity | 10 mg, 100 mg, Bulk |
