Available from stock

Josamycin

SKU: J0001

Category: Antibiotics

16846-24-5
CAS-Number: C₄₂H₆₉NO₁₅
Molecular Formula: 827.99
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥90% (HPLC)
Appearance: White to off-white powder
Identity: 1H-NMR

Properties

Solvents: water

Documentation

Safety Data Sheet (SDS): CDX J0001 MSDS.pdf

Shipping: AMBIENT
Short Term Storage: +4°C
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Transportation: Not dangerous goods

Description: A member of the leucomycin family of macrolide antibiotics produced by Streptomyces kitasatoensis. May overcome anticancer drug resistance by inhibiting the binding of vinblastine or cyclosporin A to P-glycoprotein (Pgp). An antimicrobial against a wide variety of pathogens.
Smiles: CO[C@H]1[C@@H](CC(=O)O[C@H](C)CC=CC=C[C@H](O)[C@H](C)CC(CC=O)[C@@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O2)C([C@H]1O)N(C)C)OC(C)=O
InChi Key: XJSFLOJWULLJQS-LAEWXYAOSA-N
References: (1) T. Osono et al.: J. Antibiot. 20:174-180 (1967) , (2) L. Wang et al.: Clin. Exp. Pharmacol. Physiol. 27: 587-593 (2000) , (3) M. Lovmar et al.: J. Biol. Chem. 279: 53506-53515 (2004)
InChi: InChI=1S/C42H69NO15/c1-23(2)19-32(47)56-40-27(6)53-34(22-42(40,8)50)57-37-26(5)54-41(36(49)35(37)43(9)10)58-38-29(17-18-44)20-24(3)30(46)16-14-12-13-15-25(4)52-33(48)21-31(39(38)51-11)55-28(7)45/h12-14,16,18,23-27,29-31,34-41,46,49-50H,15,17,19-22H2,1-11H3/b13-12+,16-14+/t24-,25-,26-,27+,29?,30+,31-,34+,35+,36-,37-,38+,39+,40+,41+,42-/m1/s1

A member of the leucomycin family of macrolide antibiotics produced by Streptomyces kitasatoensis. May overcome anticancer drug resistance by inhibiting the binding of vinblastine or cyclosporin A to P-glycoprotein (Pgp). An antimicrobial against a wide variety of pathogens.

SKU: J0001 Category: Antibiotics

Additional information

Additional information

Purity	≥90% (HPLC)
Appearance	White to off-white powder
CAS-Number	16846-24-5
Molecular Formula	C42H69NO15
Molecular Weight	827.99
Identity	1H-NMR
Solvents	water
Smiles	CO[C@H]1[C@@H](CC(=O)O[C@H](C)CC=CC=C[C@H](O)[C@H](C)CC(CC=O)[C@@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O2)C([C@H]1O)N(C)C)OC(C)=O
InChi Key	XJSFLOJWULLJQS-LAEWXYAOSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Transportation	Not dangerous goods
References	(1) T. Osono et al.: J. Antibiot. 20:174-180 (1967), (2) L. Wang et al.: Clin. Exp. Pharmacol. Physiol. 27: 587-593 (2000), (3) M. Lovmar et al.: J. Biol. Chem. 279: 53506-53515 (2004)
InChi	InChI=1S/C42H69NO15/c1-23(2)19-32(47)56-40-27(6)53-34(22-42(40,8)50)57-37-26(5)54-41(36(49)35(37)43(9)10)58-38-29(17-18-44)20-24(3)30(46)16-14-12-13-15-25(4)52-33(48)21-31(39(38)51-11)55-28(7)45/h12-14,16,18,23-27,29-31,34-41,46,49-50H,15,17,19-22H2,1-11H3/b13-12+,16-14+/t24-,25-,26-,27+,29?,30+,31-,34+,35+,36-,37-,38+,39+,40+,41+,42-/m1/s1
Quantity	50 mg, 200 mg, 2.5 g, Bulk