Specifications
- Purity
- ≥99% (HPLC)
- Identity
- 1H-NMR
- Appearance
- White to off-white powder
Properties
- Melting Point
- 165 - 170° C
- Solvents
- water, methanol
Downloads
- Safety Data Sheet
- CDX K0030 MSDS.pdf
Available from stock
Ketorolac tris salt
- SKU
- K0030
Category: Lipids, Fatty Acids
- Synonyms
- (±)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid tris salt , Ketorolac tromethamine , Toradol
- 74103-07-4
- CAS-Number
- C15H13NO3 · C4H11NO3
- Molecular Formula
- 376.4
- Molecular Weight
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at +4°C.
- Long Term Storage
- RT
- Short Term Storage
- RT
- Shipping
- AMBIENT
- Transportation
- Packing Group III
- RIDADR
- 2811 6.1
- Signal word
- Danger
- GHS Symbol
- GHS06
- Precautionary statements
- P261-P301 + P310-P305 + P351 + P338
- Hazard statements
- H301-H315-H319-H335
- Description
- Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) to treat pain. It is a non-selective COX inhibitor (IC50 = 20nM for both COX-1 and COX-2), thereby decreasing prostaglandins. Ketorolac is a racemic mixture containing the active (S)-ketorolac and inactive (R)-ketorolac enantiomers. Formulations containing ketorolac have been used to manage postoperative pain and as ophthalmic solutions to treat ocular pain and inflammation.
- References
- (1) K.M. Litvak & G.K. McEvoy, Clin. Pharm. 9, 921 (1990) , (2) M.M. Buckley & R.N. Brogden, Drugs 39, 86 (1990) , (3) Y. Zhang, et al., J. Pharmacol. Exp. Ther. 283, 1069 (1997) , (4) O. Laneuville, et al., J. Pharmacol. Exp. Ther. 271, 927 (1994)
- InChi Key
- BWHLPLXXIDYSNW-UHFFFAOYSA-N
- Smiles
- O=C(C1=CC=C2N1CCC2C([O-])=O)C3=CC=CC=C3.[NH3+]C(CO)(CO)CO
Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) to treat pain. It is a non-selective COX inhibitor (IC50 = 20nM for both COX-1 and COX-2), thereby decreasing prostaglandins. Ketorolac is a racemic mixture containing the active (S)-ketorolac and inactive (R)-ketorolac enantiomers. Formulations containing ketorolac have been used to manage postoperative pain and as ophthalmic solutions to treat ocular pain and inflammation.
Additional information
| Synonyms | (±)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid tris salt, Ketorolac tromethamine, Toradol |
|---|---|
| Purity | ≥99% (HPLC) |
| Appearance | White to off-white powder |
| CAS-Number | 74103-07-4 |
| Molecular Formula | C15H13NO3 · C4H11NO3 |
| Molecular Weight | 376.4 |
| Identity | 1H-NMR |
| Solvents | water, methanol |
| Melting Point | 165 – 170° C |
| Smiles | O=C(C1=CC=C2N1CCC2C([O-])=O)C3=CC=CC=C3.[NH3+]C(CO)(CO)CO |
| InChi Key | BWHLPLXXIDYSNW-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | RT |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Hazard statements | H301-H315-H319-H335 |
| Precautionary statements | P261-P301 + P310-P305 + P351 + P338 |
| GHS Symbol | GHS06 |
| Signal word | Danger |
| RIDADR | 2811 6.1 |
| Transportation | Packing Group III |
| References | (1) K.M. Litvak & G.K. McEvoy, Clin. Pharm. 9, 921 (1990), (2) M.M. Buckley & R.N. Brogden, Drugs 39, 86 (1990), (3) Y. Zhang, et al., J. Pharmacol. Exp. Ther. 283, 1069 (1997), (4) O. Laneuville, et al., J. Pharmacol. Exp. Ther. 271, 927 (1994) |
| Quantity | 1 g, 5 g, Bulk |
