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    Ketorolac tris salt

    Available from stock

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      Ketorolac tris salt

      SKU
      K0030

      Category: Lipids, Fatty Acids

      Synonyms
      (±)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid tris salt , Ketorolac tromethamine , Toradol
      74103-07-4
      CAS-Number
      C15H13NO3 · C4H11NO3
      Molecular Formula
      376.4
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥99% (HPLC)
      Identity
      1H-NMR
      Appearance
      White to off-white powder

      Properties

      Melting Point
      165 - 170° C
      Solvents
      water, methanol

      Downloads

      Safety Data Sheet
      CDX K0030 MSDS.pdf
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at +4°C.
      Long Term Storage
      RT
      Short Term Storage
      RT
      Shipping
      AMBIENT
      Transportation
      Packing Group III
      RIDADR
      2811 6.1
      Signal word
      Danger
      GHS Symbol
      GHS06
      Precautionary statements
      P261-P301 + P310-P305 + P351 + P338
      Hazard statements
      H301-H315-H319-H335
      Description
      Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) to treat pain. It is a non-selective COX inhibitor (IC50 = 20nM for both COX-1 and COX-2), thereby decreasing prostaglandins. Ketorolac is a racemic mixture containing the active (S)-ketorolac and inactive (R)-ketorolac enantiomers. Formulations containing ketorolac have been used to manage postoperative pain and as ophthalmic solutions to treat ocular pain and inflammation.
      References
      (1) K.M. Litvak & G.K. McEvoy, Clin. Pharm. 9, 921 (1990) , (2) M.M. Buckley & R.N. Brogden, Drugs 39, 86 (1990) , (3) Y. Zhang, et al., J. Pharmacol. Exp. Ther. 283, 1069 (1997) , (4) O. Laneuville, et al., J. Pharmacol. Exp. Ther. 271, 927 (1994)
      InChi Key
      BWHLPLXXIDYSNW-UHFFFAOYSA-N
      Smiles
      O=C(C1=CC=C2N1CCC2C([O-])=O)C3=CC=CC=C3.[NH3+]C(CO)(CO)CO

      Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) to treat pain. It is a non-selective COX inhibitor (IC50 = 20nM for both COX-1 and COX-2), thereby decreasing prostaglandins. Ketorolac is a racemic mixture containing the active (S)-ketorolac and inactive (R)-ketorolac enantiomers. Formulations containing ketorolac have been used to manage postoperative pain and as ophthalmic solutions to treat ocular pain and inflammation.

      SKU: K0030 Category: Lipids, Fatty Acids
      • Additional information

      Additional information

      Synonyms

      (±)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid tris salt, Ketorolac tromethamine, Toradol

      Purity

      ≥99% (HPLC)

      Appearance

      White to off-white powder

      CAS-Number

      74103-07-4

      Molecular Formula

      C15H13NO3 · C4H11NO3

      Molecular Weight

      376.4

      Identity

      1H-NMR

      Solvents

      water, methanol

      Melting Point

      165 – 170° C

      Smiles

      O=C(C1=CC=C2N1CCC2C([O-])=O)C3=CC=CC=C3.[NH3+]C(CO)(CO)CO

      InChi Key

      BWHLPLXXIDYSNW-UHFFFAOYSA-N

      Shipping

      AMBIENT

      Short Term Storage

      RT

      Long Term Storage

      RT

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at +4°C.

      Hazard statements

      H301-H315-H319-H335

      Precautionary statements

      P261-P301 + P310-P305 + P351 + P338

      GHS Symbol

      GHS06

      Signal word

      Danger

      RIDADR

      2811 6.1

      Transportation

      Packing Group III

      References

      (1) K.M. Litvak & G.K. McEvoy, Clin. Pharm. 9, 921 (1990), (2) M.M. Buckley & R.N. Brogden, Drugs 39, 86 (1990), (3) Y. Zhang, et al., J. Pharmacol. Exp. Ther. 283, 1069 (1997), (4) O. Laneuville, et al., J. Pharmacol. Exp. Ther. 271, 927 (1994)

      Quantity

      1 g, 5 g, Bulk

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