Specifications
- Purity
- ≥97% (HPLC)
- Identity
- 1H-NMR
- Appearance
- White to off-white powder
Properties
- Melting Point
- 150-153 °C (lit.)
- Solvents
- water (50 mg/ml) or DMSO.
Downloads
- Safety Data Sheet
- CDX F0158 MSDS.pdf
Available from stock
L-(-)-Fucose
- SKU
- F0158
Category: Carbohydrates
- Synonyms
- 6-Deoxy-L-galactose , L-Galactomethylose , 6-Desoxygalactose
- 2438-80-4
- CAS-Number
- C6H12O5
- Molecular Formula
- 164.16
- Molecular Weight
- Short Term Storage
- +4°C
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Handling Advice
- Protect from light and moisture.
- Long Term Storage
- -20°C
- Shipping
- AMBIENT
- Transportation
- Not dangerous goods
- Description
- L-(-)-Fucose is a deoxyhexose monosaccharide found on N- and O-linked glycans and glycolipids of a wide variety of organisms. It can exist as a terminal modification of glycan structures or serve as a point of attachment for adding other sugars. In humans, L-(-)-fucose plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion and host-microbe interactions. L-Fucose has several potential applications in cosmetics, pharmaceuticals and dietary supplements. Fucosylation of antibodies has been established to reduce binding to the Fc receptor of Natural Killer cells and thereby reduce antigen-dependent cellular cytotoxicity. L-Fucose is used as a substrate to identify, differentiate and characterize enzymes such as the fucosidase(s), l-fucose isomerase(s) and L-fucose dehydrogenase(s). L-Fucose may be used as a reference compound in rare sugar identification and analysis.
- InChi
- InChI=1S/C6H12O5/c1-3(8)5(10)6(11)4(9)2-7/h2-6,8-11H,1H3/t3-,4+,5+,6-/m0/s1
- References
- (1) D.J. Moloney & R.S. Haltiwanger, Glycobiology 9, 679 (1999) , (2) P.T. Vanhooren & E.J. Vandamme, J. Chem. Technol. Biotech. 74, 479 (1999) (Review) , (3) D.J. Becker & J.B. Lowe, Glycobiology 13, 41R (2003) (Review) , (4) C. Roca, et al., Front. Microbiol. 6, 288 (2015) , (5) X. Yu, et al., BioDrugs 31, 151 (2017)
- InChi Key
- PNNNRSAQSRJVSB-KCDKBNATSA-N
- Smiles
- O=C([H])[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)C
L-(-)-Fucose is a deoxyhexose monosaccharide found on N- and O-linked glycans and glycolipids of a wide variety of organisms. It can exist as a terminal modification of glycan structures or serve as a point of attachment for adding other sugars. In humans, L-(-)-fucose plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion and host-microbe interactions. L-Fucose has several potential applications in cosmetics, pharmaceuticals and dietary supplements. Fucosylation of antibodies has been established to reduce binding to the Fc receptor of Natural Killer cells and thereby reduce antigen-dependent cellular cytotoxicity. L-Fucose is used as a substrate to identify, differentiate and characterize enzymes such as the fucosidase(s), l-fucose isomerase(s) and L-fucose dehydrogenase(s). L-Fucose may be used as a reference compound in rare sugar identification and analysis.
Additional information
| Synonyms | 6-Deoxy-L-galactose, L-Galactomethylose, 6-Desoxygalactose |
|---|---|
| Purity | ≥97% (HPLC) |
| Appearance | White to off-white powder |
| CAS-Number | 2438-80-4 |
| Molecular Formula | C6H12O5 |
| Molecular Weight | 164.16 |
| Identity | 1H-NMR |
| Solvents | water (50 mg/ml) or DMSO. |
| Melting Point | 150-153 °C (lit.) |
| Smiles | O=C([H])[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)C |
| InChi Key | PNNNRSAQSRJVSB-KCDKBNATSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Transportation | Not dangerous goods |
| References | (1) D.J. Moloney & R.S. Haltiwanger, Glycobiology 9, 679 (1999), (2) P.T. Vanhooren & E.J. Vandamme, J. Chem. Technol. Biotech. 74, 479 (1999) (Review), (3) D.J. Becker & J.B. Lowe, Glycobiology 13, 41R (2003) (Review), (4) C. Roca, et al., Front. Microbiol. 6, 288 (2015), (5) X. Yu, et al., BioDrugs 31, 151 (2017) |
| InChi | InChI=1S/C6H12O5/c1-3(8)5(10)6(11)4(9)2-7/h2-6,8-11H,1H3/t3-,4+,5+,6-/m0/s1 |
| Quantity | 5 g, 25 g, Bulk |
