Specifications
- Purity
- 99.0-101.0% (Assay)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- water (25 mg/ml).
- Melting Point
- 185.5 °C (decomp.)
- Density
- 1.321 g/mL (predicted)
Available from stock
L-Glutamine
- SKU
- G0041
Category: Amino Acids, Peptides, Proteins
- Synonyms
- " (+)-Glutamine , Levoglutamide , (S)-2,5-Diamino-5-oxopentanoic acid , L-Glutamic acid 5-amide , NSC 27421 , H-Gln-OH"
- 56-85-9
- CAS-Number
- C5H10N2O3
- Molecular Formula
- 146.14
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- RT
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at RT.
- Transportation
- Not dangerous goods
- Description
- L-Glutamine is an amino acid and is essential in the formation of purine and pyrimidine nucleotides, amino sugars, glutathione, L-glutamate and other amino acids as well as in protein synthesis and glucose production. It plays also a role in lipid synthesis (e.g. in cancer cells), cellular energy as a source next to glucose, nitrogen donation for many anabolic processes, including the synthesis of purines and carbon donation, as a source refilling the citric acid cycle. It is a nontoxic transporter of ammonia in the blood circulation and a precursor to the neurotransmitter glutamate and GABA. L-Glutamine is an essential amino acid which is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine exerts potent antioxidant and anti-inflammatory effects, next to its roles in cell proliferation and cancer. Levels of L-glutamine in human white adipose tissue (WAT) are linked with obesity-associated inflammation. Addition of L-glutamine in obese mice attenuated adipose tissue inflammation. Reduced L-glutamine levels during obesity shift the balance from glutaminolysis toward glycolysis, leading to nuclear O-GlcNAcylation, which activates inflammation.
- Smiles
- NC(CC[C@H](N)C(O)=O)=O
- InChi Key
- ZDXPYRJPNDTMRX-VKHMYHEASA-N
- References
- (1) A.L. Miller, Altern. Med. Rev. 4, 239 (1999) (Review) , (2) P. Newsholme, J. Nutr. 131, 2515S (2001) (Review) , (3) D. Kelly & P.E. Wischmeyer, Curr. Opin. Clin. Nutr. Metab. Care 6, 217 (2003) (Review) , (4) R.H. van den Heuvel, et al., Cell Mol. Life Sci. 61, 669 (2004) (Review) , (5) H.A. Martins, et al., Amino Acids 48, 2773 (2016) , (6) P. Petrus, et al., Cell Metab. 31, 375 (2020)
- InChi
- InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1
L-Glutamine is an amino acid and is essential in the formation of purine and pyrimidine nucleotides, amino sugars, glutathione, L-glutamate and other amino acids as well as in protein synthesis and glucose production. It plays also a role in lipid synthesis (e.g. in cancer cells), cellular energy as a source next to glucose, nitrogen donation for many anabolic processes, including the synthesis of purines and carbon donation, as a source refilling the citric acid cycle. It is a nontoxic transporter of ammonia in the blood circulation and a precursor to the neurotransmitter glutamate and GABA. L-Glutamine is an essential amino acid which is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine exerts potent antioxidant and anti-inflammatory effects, next to its roles in cell proliferation and cancer. Levels of L-glutamine in human white adipose tissue (WAT) are linked with obesity-associated inflammation. Addition of L-glutamine in obese mice attenuated adipose tissue inflammation. Reduced L-glutamine levels during obesity shift the balance from glutaminolysis toward glycolysis, leading to nuclear O-GlcNAcylation, which activates inflammation.
Additional information
| Synonyms | " (+)-Glutamine, Levoglutamide, (S)-2,5-Diamino-5-oxopentanoic acid, L-Glutamic acid 5-amide, NSC 27421, H-Gln-OH" |
|---|---|
| Purity | 99.0-101.0% (Assay) |
| Appearance | White to off-white powder |
| CAS-Number | 56-85-9 |
| Molecular Formula | C5H10N2O3 |
| Molecular Weight | 146.14 |
| Identity | 1H-NMR |
| Solvents | water (25 mg/ml). |
| Melting Point | 185.5 °C (decomp.) |
| Density | 1.321 g/mL (predicted) |
| Smiles | NC(CC[C@H](N)C(O)=O)=O |
| InChi Key | ZDXPYRJPNDTMRX-VKHMYHEASA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | RT |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
| Transportation | Not dangerous goods |
| References | (1) A.L. Miller, Altern. Med. Rev. 4, 239 (1999) (Review), (2) P. Newsholme, J. Nutr. 131, 2515S (2001) (Review), (3) D. Kelly & P.E. Wischmeyer, Curr. Opin. Clin. Nutr. Metab. Care 6, 217 (2003) (Review), (4) R.H. van den Heuvel, et al., Cell Mol. Life Sci. 61, 669 (2004) (Review), (5) H.A. Martins, et al., Amino Acids 48, 2773 (2016), (6) P. Petrus, et al., Cell Metab. 31, 375 (2020) |
| InChi | InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 |
| Quantity | 25 g, 100 g, 500 g, Bulk |
