Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- water (50 mg/ml), ethanol
Available from stock
L-Proline
- SKU
- P0446
Category: Amino Acids, Peptides, Proteins
- Synonyms
- (S)-Pyrrolidine-2-carboxylic acid , H-Pro-OH
- 147-85-3
- CAS-Number
- C5H9NO2
- Molecular Formula
- 115.13
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- RT
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at RT.
- Transportation
- Not dangerous goods
- Description
- Proline is a proteinogenic amino acid that is used in the biosynthesis of proteins. L-Proline has been found to act as a weak agonist of the glycine receptor and of both NMDA and non-NMDA (AMPA/kainate) ionotropic glutamate receptors. L-proline is essential for induction of hepatocyte proliferation in culture, through its affect on synthesis of intracellular collagen. It has free radical scavenging potential. Induces differentiation of embyonic stem cells and has been studied as regulator of pluripotent cells in culture. Shows cryoprotective properties. L-Proline is used as asymmetric catalysts in organic synthesis and asymmetric aldol cyclization. It is involved in the Michael addition of dimethyl malonate to alfa-beta-unsaturated aldehydes. It finds uses in pharmaceutical, biotechnological applications due to its osmoprotectant property.
- Smiles
- O=C(O)[C@H]1NCCC1
- InChi Key
- ONIBWKKTOPOVIA-BYPYZUCNSA-N
- References
- (1) A. Van Harreveld & F. Strumwasser F., Neuroscience 6, 2495 (1981) , (2) E. Keller, et al., J. Neurochem. 37, 1335 (1981) , (3) T. Nakamura, et al., BBRC 122, 884 (1984) , (4) V. Henzi, et al., Mol. Pharmacol. 41, 793 (1992) , (5) S. Usse, et al., J. Org. Chem. 65, 914 (2000) , (6) S. Kaul, et al., Amino Acids 34, 315 (2008) , (7) N. Verbruggen & C. Hermans, Amino Acids 35, 753 (2008) (Review) , (8) J.M. Washington, et al., Am. J. Physiol. Cell Physiol. 298, C982 (2010) , (9) G. Zhang, et al., Chem. Commun. 49, 7908 (2013) , (10) S. Comes, et l., Stem Cell Reports 1, 307 (2013) , (11) H. Jin, et al., J. Org. CHem. 81, 3263 (2016) , (12) L. Zahng, et al., Sci. Rep. 6, 26326 (2016)
Proline is a proteinogenic amino acid that is used in the biosynthesis of proteins. L-Proline has been found to act as a weak agonist of the glycine receptor and of both NMDA and non-NMDA (AMPA/kainate) ionotropic glutamate receptors. L-proline is essential for induction of hepatocyte proliferation in culture, through its affect on synthesis of intracellular collagen. It has free radical scavenging potential. Induces differentiation of embyonic stem cells and has been studied as regulator of pluripotent cells in culture. Shows cryoprotective properties. L-Proline is used as asymmetric catalysts in organic synthesis and asymmetric aldol cyclization. It is involved in the Michael addition of dimethyl malonate to alfa-beta-unsaturated aldehydes. It finds uses in pharmaceutical, biotechnological applications due to its osmoprotectant property.
Additional information
| Synonyms | (S)-Pyrrolidine-2-carboxylic acid, H-Pro-OH |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | White to off-white powder |
| CAS-Number | 147-85-3 |
| Molecular Formula | C5H9NO2 |
| Molecular Weight | 115.13 |
| Identity | 1H-NMR |
| Solvents | water (50 mg/ml), ethanol |
| Smiles | O=C(O)[C@H]1NCCC1 |
| InChi Key | ONIBWKKTOPOVIA-BYPYZUCNSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | RT |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
| Transportation | Not dangerous goods |
| References | (1) A. Van Harreveld & F. Strumwasser F., Neuroscience 6, 2495 (1981), (2) E. Keller, et al., J. Neurochem. 37, 1335 (1981), (3) T. Nakamura, et al., BBRC 122, 884 (1984), (4) V. Henzi, et al., Mol. Pharmacol. 41, 793 (1992), (5) S. Usse, et al., J. Org. Chem. 65, 914 (2000), (6) S. Kaul, et al., Amino Acids 34, 315 (2008), (7) N. Verbruggen & C. Hermans, Amino Acids 35, 753 (2008) (Review), (8) J.M. Washington, et al., Am. J. Physiol. Cell Physiol. 298, C982 (2010), (9) G. Zhang, et al., Chem. Commun. 49, 7908 (2013), (10) S. Comes, et l., Stem Cell Reports 1, 307 (2013), (11) H. Jin, et al., J. Org. CHem. 81, 3263 (2016), (12) L. Zahng, et al., Sci. Rep. 6, 26326 (2016) |
| Quantity | 100 g, 1 kg, Bulk |
