Available from stock
Category: Fluorescent Detection
N,N-Dimethyl-6-dodecanoyl-2-naphthylamine (Laurdan) is used as an environmentally sensitive probe for the labeling of plasma membranes. The lauroyl-sidechain integrates into the hydrophobic core of biological membranes, the polar fluorescent moiety is at level of the glycerol-backbone. Dipolar relaxation processes of the naphtylamine-moiety with neighboring polar molecules lead to wavelength-shifts of the emission-spectra. The physical state of the membrane and effects of temperature, cholesterol or ethanol on various membrane-systems have been monitored.
| Synonyms | N,N-Dimethyl-6-dodecanoyl-2-naphthylamine |
|---|---|
| Purity | ≥97% (HPLC) |
| Appearance | Light yellow solid |
| CAS-Number | 74515-25-6 |
| Molecular Formula | C24H35NO |
| Molecular Weight | 353.54 |
| Identity | 1H-NMR |
| Solvents | methanol, DMF, acetonitrile, chloroform |
| Melting Point | 88 °C (lit.) |
| Fluorescence | λex 366 nm, λem 497 nm in methanol |
| Smiles | CCCCCCCCCCCC(=O)C1=CC2=CC=C(C=C2C=C1)N(C)C |
| InChi Key | JHDGGIDITFLRJY-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Transportation | Not dangerous goods |
| References | (1) S.S. Antollini et al.: Meth. Mol. Biol. 400, 531 (2007), (2) Y.L. Zhang et al.: Biochem. Biophys. Res. Comm. 347(3), 838 (2006), (3) L. Bagatolli et al.: Biochimica et Biophysica Acta 1325, 80 (1997), (4) L.I. Hellgren et al.: Plant Physiol. Biochem. 34(4), 455 (1996), (5) G. Weber et al.: Biochemistry 18(14), 3075 (1979) |
| InChi | InChI=1S/C24H35NO/c1-4-5-6-7-8-9-10-11-12-13-24(26)22-15-14-21-19-23(25(2)3)17-16-20(21)18-22/h14-19H,4-13H2,1-3H3 |
| Quantity | 50 mg, 250 mg, 1 g, Bulk |
DAR-2 
