Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- Solid
- Identity
- 1H-NMR
Properties
- Solvents
- water (20 mg/ml)
Category: API's & Intermediates
Levocetirizine hydrochloride is the (R)-enantiomer of the histamine H1 receptor antagonist and antihistamine agent cetirizine. It binds to the H1 receptor with higher affinity than cetirizine and is 25,000-100,000-fold selective for H1 receptors over muscarinic M1-M5 receptors. Intranasal administration dose-dependently decreases histamine-induced nasal rubbing and sneezing in mice. Has been used in the treatment of allergic rhinitis and chronic idiopathic urticaria.
Synonyms | (R)-Cetirizine dihydrochloride, (-)-Cetirizine dihydrochloride, 2-[2-[4-[(R)-(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid dihydrochloride |
---|---|
Purity | ≥98% (HPLC) |
Appearance | Solid |
CAS-Number | 130018-87-0 |
Molecular Formula | C21H25ClN2O3·2HC |
Molecular Weight | 461.81 |
Identity | 1H-NMR |
Solvents | water (20 mg/ml) |
Smiles | ClC1=CC=C([C@H](N2CCN(CCOCC(O)=O)CC2)C3=CC=CC=C3)C=C1.Cl.Cl |
InChi Key | PGLIUCLTXOYQMV-GHVWMZMZSA-N |
Shipping | AMBIENT |
Short Term Storage | RT |
Long Term Storage | RT |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
Hazard statements | H302-H400 |
Precautionary statements | P273 |
GHS Symbol | GHS07+GHS09 |
Signal word | Warning |
RIDADR | 3077 9 |
Transportation | Packing Group III |
References | (1) M. Gillard, et al., Inflamm. Res. 52, S49 (2003), (2) L. Zhang, et al., Pharmacol. 92, 14 (2013), (3) C. Kitayama-Sugiyama, et al., Immunotoxicol. 35, 545 (2013), (4) A. Kanei, et al., In Vivo 28, 657 (2014) |
Quantity | 10 mg, 50 mg, Bulk |