Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (10mg/ml), DMF (20mg/ml)
Downloads
- Safety Data Sheet
- CDX L0280 MSDS.pdf
Category: Phytochemicals
Limonin is the first described limonoid, which are naturally occurring tetranortriterpenoids that impart bitter flavor in citrus fruits. Compounds belonging to this group have reported anti-proliferative and proapoptotic activity on several cancer cell lines as well as pesticidal, anti-malarial, anti-microbial, anti-HIV, anti-inflammatory, antinociceptive and neuroprotective activity. Shown to inhibit arginase I and II and P-glycoprotein. May be used in assays as control, standard or competitor, or in studies on the physiology, metabolism and biosynthesis of limonin.
Synonyms | 7,16-Dioxo-7,16-dideoxylimondiol, Limonoic acid di-δ-lactone, Citrolimonin, Dictamnolactone, Evodin, Limonine, Obaculactone, NSC 36508 |
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Purity | ≥98% (HPLC) |
Appearance | White to off-white powder |
CAS-Number | 1180-71-8 |
Molecular Formula | C26H30O8 |
Molecular Weight | 470.51 |
Identity | 1H-NMR |
Solvents | DMSO (10mg/ml), DMF (20mg/ml) |
Smiles | O=C1[C@@]2(C)[C@@]34O[C@@H]3C(O[C@@H](C5=COC=C5)[C@]4(C)CC[C@]2([H])[C@]67[C@](C1)([H])C(C)(C)O[C@@]6([H])CC(OC7)=O)=O |
InChi Key | KBDSLGBFQAGHBE-MSGMIQHVSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Transportation | Not dangerous goods |
References | (1) V.P. Maier, et al., ACS Symposium Series 143, 63 (1980), (2) J.A. Klocke & I. Kubo, Ent. Exp. & Appl. 32, 299 (1982), (3) H. Matsuda, et al., Planta Med. 64, 339 (1998), (4) L. Battinelli, et al., Planta Med. 69, 910 (2003), (5) A. Roy & S. Saraf, Biol. Pharm. Bull. 29, 191 (2006) (Review), (6) J.S. Yoon, et al., J. Nat. Prod. 71, 208 (2008), (7) J.S. Yoon, et al., Mol. Neurosci. 42, 9 (2010), (8) M.Z. El-Readi, et al., Eur. J. Pharmacol. 626, 139 (2010), (9) K.N. Chidambara Murthy, et al., J. Agric. Food Chem. 59, 2314 (2011), (10) A. Rahman, et al., Anticancer Agents Med. Chem. 15, 236 (2015), (11) R. Gualdani, et al., Molecules 21, E1530 (2016) (Review), (12) B.H. Koo, et al., Yonsei Med. J. 59, 366 (2018) |
InChi | InChI=1S/C26H30O8/c1-22(2)15-9-16(27)24(4)14(25(15)12-31-18(28)10-17(25)33-22)5-7-23(3)19(13-6-8-30-11-13)32-21(29)20-26(23,24)34-20/h6,8,11,14-15,17,19-20H,5,7,9-10,12H2,1-4H3/t14-,15-,17-,19-,20+,23-,24-,25+,26+/m0/s1 |
Quantity | 50 mg, Bulk |