Specifications
- Purity
- ≥98% (HPLC)
- Identity
- 1H-NMR
- Appearance
- White powder
Properties
- Melting Point
- 110-112 °C
- Solvents
- chloroform, DCM
Available from stock
Litihium ionophore III
- SKU
- L0123
- Synonyms
- ETH 1810 , N,N-Dicyclohexyl-N',N'-diisobutyl-cis-cyclohexane-1,2-dicarboxamide
- 99281-50-2
- CAS-Number
- C28H50N2O2
- Molecular Formula
- 446.71
- Molecular Weight
- Short Term Storage
- +4°C
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Handling Advice
- Protect from light and moisture.
- Long Term Storage
- -20°C
- Shipping
- AMBIENT
- Transportation
- Not dangerous goods
- Description
- Lithium ionophore III (ETH 1810) has been used in liquid membrane electrodes for the determination of Li concentration in blood. It is a neutral non-cyclic Li(+)-selective ionophore, which can transport lithium and other monovalent cations, across lipid bilayer membranes, forming 2:1 ionophore:ion membrane-permeating species. The selectivity is Li+ > Na+ > K+ > Cs+. ETH 1810 was also found to be capable of acting as a carrier of biogenic amines and related molecules, with the following selectivity sequence: Tryptamine > Phenylethylamine > Tyramine > Serotonin > Li+ > NH+4 > Dopamine. Protons at physiological concentrations do not interfere with the lithium transport.
- InChi
- InChI=1S/C28H50N2O2/c1-21(2)19-29(20-22(3)4)27(31)25-17-11-12-18-26(25)28(32)30(23-13-7-5-8-14-23)24-15-9-6-10-16-24/h21-26H,5-20H2,1-4H3/t25-,26+/m0/s1
- References
- (1) E. Metzger et al. Anal. Chem. 59, 1600, (1987) , (2) A. Zeevi & R. Margalit, J. Membr. Biol. 121, 133 (1991) , (3) A. Zeevi & R. Margalit, Arch. Biochem. Biophys. 298, 84 (1992) , (4) E. Bakker & E. Pretsch, Anal. Chem. 70, 295 (1998)
- InChi Key
- QGKITQHJONXIQV-IZZNHLLZSA-N
- Smiles
- O=C(N(C1CCCCC1)C2CCCCC2)[C@H]3[C@@H](C(N(CC(C)C)CC(C)C)=O)CCCC3
Lithium ionophore III (ETH 1810) has been used in liquid membrane electrodes for the determination of Li concentration in blood. It is a neutral non-cyclic Li(+)-selective ionophore, which can transport lithium and other monovalent cations, across lipid bilayer membranes, forming 2:1 ionophore:ion membrane-permeating species. The selectivity is Li+ > Na+ > K+ > Cs+. ETH 1810 was also found to be capable of acting as a carrier of biogenic amines and related molecules, with the following selectivity sequence: Tryptamine > Phenylethylamine > Tyramine > Serotonin > Li+ > NH+4 > Dopamine. Protons at physiological concentrations do not interfere with the lithium transport.
Additional information
| Synonyms | ETH 1810, N,N-Dicyclohexyl-N',N'-diisobutyl-cis-cyclohexane-1,2-dicarboxamide |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | White powder |
| CAS-Number | 99281-50-2 |
| Molecular Formula | C28H50N2O2 |
| Molecular Weight | 446.71 |
| Identity | 1H-NMR |
| Solvents | chloroform, DCM |
| Melting Point | 110-112 °C |
| Smiles | O=C(N(C1CCCCC1)C2CCCCC2)[C@H]3[C@@H](C(N(CC(C)C)CC(C)C)=O)CCCC3 |
| InChi Key | QGKITQHJONXIQV-IZZNHLLZSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Transportation | Not dangerous goods |
| References | (1) E. Metzger et al. Anal. Chem. 59, 1600, (1987), (2) A. Zeevi & R. Margalit, J. Membr. Biol. 121, 133 (1991), (3) A. Zeevi & R. Margalit, Arch. Biochem. Biophys. 298, 84 (1992), (4) E. Bakker & E. Pretsch, Anal. Chem. 70, 295 (1998) |
| InChi | InChI=1S/C28H50N2O2/c1-21(2)19-29(20-22(3)4)27(31)25-17-11-12-18-26(25)28(32)30(23-13-7-5-8-14-23)24-15-9-6-10-16-24/h21-26H,5-20H2,1-4H3/t25-,26+/m0/s1 |
| Quantity | 50 mg, Bulk |
