Luteolin

SKU: L0087

Category: Lipids, Fatty Acids

Synonyms: 3',4',5,7-Tetrahydroxyflavone , Luteolol , BRN 0292084 , C.I. Natural Yellow 2 , Digitoflavone , Flacitran , Flavopurpol , Daphneflavonol , Argemexitin; 491-70-3
CAS-Number: C₁₅H₁₀O₆
Molecular Formula: 286.24
Molecular Weight

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (TLC)
Identity: 1H-NMR
Appearance: Yellow powder

Properties

Solvents: DMSO (10mg/ml), DMF (20mg/ml), methanol, ethanol (5mg/ml)

Short Term Storage: +4°C
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.
Handling Advice: Protect from light and moisture.
Long Term Storage: +4°C
Shipping: AMBIENT

Transportation: Not dangerous goods

Description: Luteolin is a hydroxylated flavone derivative that is a strong antioxidant and radical scavenger. It has multiple activities, such as anticancer, antimetastatic, anti-adipogenic, anti-inflammatory and neuroprotective. Luteolin has been described as a fatty acid synthase (FASN), 15-lipoxygenase, alpha-glucosidase, PPAR-γ, topoisomerase I, PI3K/Akt, RSK1/RSK2 and HDAC inhibitor.
References: (1) Y.T. Huang, et al., Br. J. Pharmacol. 128, 999 (1999) , (2) J.S. Kim, et al., Biosci. Biotechnol. Biochem. 64, 2458 (2000) , (3) H. Ueda, et al., Biol. Pharm. Bull. 25, 1197 (2002) , (4) A.R. Chowdhury, et al., Biochem. J. 366, 653 (2002) , (5) L. Sartor, et al., Biochem. Pharmacol. 64, 229 (2002) , (6) C.D. Sadik, et al., Biochem. Pharmacol. 65, 773 (2003) , (7) D.T. Coleman, et al., Mol. Cancer Ther. 8, 214 (2009) , (8) K. Xu, et al., Molecules 14, 3486 (2009) , (9) H.S. Park, et al., Biofactors 35, 373 (2009) , (10) S. Attoub, et al., Eur. J. Pharmacol. 651, 18 (2011) , (11) H.Y. Kim, et al., Phytother. Res. 27, 1481 (2013) , (12) K.M. Reipas, et al., Oncotarget 4, 329 (2013)
InChi Key: IQPNAANSBPBGFQ-UHFFFAOYSA-N
Smiles: OC1=C2C(OC(C3=CC(O)=C(O)C=C3)=CC2=O)=CC(O)=C1

Luteolin is a hydroxylated flavone derivative that is a strong antioxidant and radical scavenger. It has multiple activities, such as anticancer, antimetastatic, anti-adipogenic, anti-inflammatory and neuroprotective. Luteolin has been described as a fatty acid synthase (FASN), 15-lipoxygenase, alpha-glucosidase, PPAR-γ, topoisomerase I, PI3K/Akt, RSK1/RSK2 and HDAC inhibitor.

SKU: L0087 Category: Lipids, Fatty Acids

Additional information

Additional information

Synonyms	3',4',5,7-Tetrahydroxyflavone, Luteolol, BRN 0292084, C.I. Natural Yellow 2, Digitoflavone, Flacitran, Flavopurpol, Daphneflavonol, Argemexitin
Purity	≥98% (TLC)
Appearance	Yellow powder
CAS-Number	491-70-3
Molecular Formula	C15H10O6
Molecular Weight	286.24
Identity	1H-NMR
Solvents	DMSO (10mg/ml), DMF (20mg/ml), methanol, ethanol (5mg/ml)
Smiles	OC1=C2C(OC(C3=CC(O)=C(O)C=C3)=CC2=O)=CC(O)=C1
InChi Key	IQPNAANSBPBGFQ-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Transportation	Not dangerous goods
References	(1) Y.T. Huang, et al., Br. J. Pharmacol. 128, 999 (1999), (2) J.S. Kim, et al., Biosci. Biotechnol. Biochem. 64, 2458 (2000), (3) H. Ueda, et al., Biol. Pharm. Bull. 25, 1197 (2002), (4) A.R. Chowdhury, et al., Biochem. J. 366, 653 (2002), (5) L. Sartor, et al., Biochem. Pharmacol. 64, 229 (2002), (6) C.D. Sadik, et al., Biochem. Pharmacol. 65, 773 (2003), (7) D.T. Coleman, et al., Mol. Cancer Ther. 8, 214 (2009), (8) K. Xu, et al., Molecules 14, 3486 (2009), (9) H.S. Park, et al., Biofactors 35, 373 (2009), (10) S. Attoub, et al., Eur. J. Pharmacol. 651, 18 (2011), (11) H.Y. Kim, et al., Phytother. Res. 27, 1481 (2013), (12) K.M. Reipas, et al., Oncotarget 4, 329 (2013)
Quantity	10 mg, 50 mg, Bulk