Available from stock

Magnolol

SKU: M0170

Category: Phytochemicals

Synonyms: 5,5'-Diallyl-2,2'-biphenyldiol , NSC 293099; 528-43-8
CAS-Number: C₁₈H₁₈O₂
Molecular Formula: 266.33
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: White to off-white powder
Identity: 1H-NMR

Properties

Solvents: ethanol (1mg/ml), methanol (1mg/ml), DMSO (10mg/ml), DMF (10mg/ml)
Melting Point: 101 - 102 °C

Shipping: AMBIENT
Short Term Storage: +4°C
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Hazard statements: H315-H318-H335-H411
Precautionary statements: P261-P273-P280-P305 + P351 + P338
GHS Symbol: GHS05+GHS07+GHS09
Signal word: Danger
RIDADR: UN 3077 9
Transportation: Packing Group III

Description: Magnolol is a bioactive compound isolated from the bark of M. officinalis that has been used in Asian traditional medicine for the treatment of anxiety, sleep disorders, and allergic diseases. Magnolol is an antifungal, antibacterial and antioxidant compound. It demonstrates anti-inflammatory activity by interferring with NF-?B signalling and NLRP3 inhibition. Magnolol can activate cannabinoid (CB) receptors, behaving as a partial agonist with selectivity for the peripheral CB2 subtype versus central CB1. It been identified as modulators of the GABAA receptors in vitro. It is a potent antitumor and antiangiogenic compound. Shown to inhibit HIF-1alpha/VEGF signalling, inhibiting invasion and metastasis through MMP2/MMP9 and inhibiting microtubule polymerization. Induces apoptosis through EGFR/PI3K/Akt pathway. Shows anti-diabetic/anti-obesity activity targeting nuclear receptors retinoic X receptor alpha (RXRalpha) and peroxisome proliferator activated receptor γ (PPARγ). In addition promotes thermogenesis.
Smiles: OC1=CC=C(CC=C)C=C1C2=CC(CC=C)=CC=C2O
InChi Key: VVOAZFWZEDHOOU-UHFFFAOYSA-N
References: (1) K. Watanabe, et al., Planta Med. 49, 103 (1983) , (2) J.P. Wang, et al., Naunyn Schmiedebergs Arch. Pharmacol. 346, 707 (1992) , (3) Y. Maruyama, et al., J. Nat. Prod. 61, 135 (1998) , (4) K.H. Bang, et al., Arch. Pharm. Res. 23, 46 (2000) , (5) K.Y. Ho, et al., Phytother. Res. 15, 139 (2001) , (6) J. Ai, et al., Pharmacology 63, 34 (2001) , (7) K. Ikeda & H. Nagase, Biol. Pharm. Bull. 25, 1546 (2002) , (8) K. Ikeda, et al., Phytother. Res. 17, 933 (2003) , (9) J. Park, et al., Eur. J. Pharmacol. 496, 189 (2004) , (10) A.K. Tse, et al., Mol. Immunol. 44, 2647 (2007) , (11) D.H. Lee, et al., J. Cell Biochem. 106, 1113 (2009) , (12) E.S. Hwang & K.K. Park, Biosci. Biotechnol. Biochem. 74, 961 (2010) , (13) H. Zhang, et al., PLoS One 6, e28253 (2011) , (14) V. Rempel, et al., ACS Med. Chem. Lett. 4, 41 (2013) , (15) M.C. Chen, et al., Biochem. Pharmacol. 85, 1278 (2013) , (16) Y. Sakaue, et al., Microbiol. Immunol. 60, 10 (2016) , (17) J. Shen, et al., Cell Physiol. Biochem. 42, 1789 (2017) , (18) F. Huang, et al., Mol. Med. Rep. 16, 4817 (2017) , (19) H.A. Parray, et al., Nutrition 50, 82 (2018)

Magnolol is a bioactive compound isolated from the bark of M. officinalis that has been used in Asian traditional medicine for the treatment of anxiety, sleep disorders, and allergic diseases. Magnolol is an antifungal, antibacterial and antioxidant compound. It demonstrates anti-inflammatory activity by interferring with NF-?B signalling and NLRP3 inhibition. Magnolol can activate cannabinoid (CB) receptors, behaving as a partial agonist with selectivity for the peripheral CB2 subtype versus central CB1. It been identified as modulators of the GABAA receptors in vitro. It is a potent antitumor and antiangiogenic compound. Shown to inhibit HIF-1alpha/VEGF signalling, inhibiting invasion and metastasis through MMP2/MMP9 and inhibiting microtubule polymerization. Induces apoptosis through EGFR/PI3K/Akt pathway. Shows anti-diabetic/anti-obesity activity targeting nuclear receptors retinoic X receptor alpha (RXRalpha) and peroxisome proliferator activated receptor γ (PPARγ). In addition promotes thermogenesis.

SKU: M0170 Category: Phytochemicals

Additional information

Additional information

Synonyms	5,5'-Diallyl-2,2'-biphenyldiol, NSC 293099
Purity	≥98% (HPLC)
Appearance	White to off-white powder
CAS-Number	528-43-8
Molecular Formula	C18H18O2
Molecular Weight	266.33
Identity	1H-NMR
Solvents	ethanol (1mg/ml), methanol (1mg/ml), DMSO (10mg/ml), DMF (10mg/ml)
Melting Point	101 – 102 °C
Smiles	OC1=CC=C(CC=C)C=C1C2=CC(CC=C)=CC=C2O
InChi Key	VVOAZFWZEDHOOU-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements	H315-H318-H335-H411
Precautionary statements	P261-P273-P280-P305 + P351 + P338
GHS Symbol	GHS05+GHS07+GHS09
Signal word	Danger
RIDADR	UN 3077 9
Transportation	Packing Group III
References	(1) K. Watanabe, et al., Planta Med. 49, 103 (1983), (2) J.P. Wang, et al., Naunyn Schmiedebergs Arch. Pharmacol. 346, 707 (1992), (3) Y. Maruyama, et al., J. Nat. Prod. 61, 135 (1998), (4) K.H. Bang, et al., Arch. Pharm. Res. 23, 46 (2000), (5) K.Y. Ho, et al., Phytother. Res. 15, 139 (2001), (6) J. Ai, et al., Pharmacology 63, 34 (2001), (7) K. Ikeda & H. Nagase, Biol. Pharm. Bull. 25, 1546 (2002), (8) K. Ikeda, et al., Phytother. Res. 17, 933 (2003), (9) J. Park, et al., Eur. J. Pharmacol. 496, 189 (2004), (10) A.K. Tse, et al., Mol. Immunol. 44, 2647 (2007), (11) D.H. Lee, et al., J. Cell Biochem. 106, 1113 (2009), (12) E.S. Hwang & K.K. Park, Biosci. Biotechnol. Biochem. 74, 961 (2010), (13) H. Zhang, et al., PLoS One 6, e28253 (2011), (14) V. Rempel, et al., ACS Med. Chem. Lett. 4, 41 (2013), (15) M.C. Chen, et al., Biochem. Pharmacol. 85, 1278 (2013), (16) Y. Sakaue, et al., Microbiol. Immunol. 60, 10 (2016), (17) J. Shen, et al., Cell Physiol. Biochem. 42, 1789 (2017), (18) F. Huang, et al., Mol. Med. Rep. 16, 4817 (2017), (19) H.A. Parray, et al., Nutrition 50, 82 (2018)
Quantity	10 mg, Bulk