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    Magnolol

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      Magnolol

      SKU
      M0170

      Category: Phytochemicals

      Synonyms
      5,5'-Diallyl-2,2'-biphenyldiol , NSC 293099
      528-43-8
      CAS-Number
      C18H18O2
      Molecular Formula
      266.33
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥98% (HPLC)
      Identity
      1H-NMR
      Appearance
      White to off-white powder

      Properties

      Melting Point
      101 - 102 °C
      Solvents
      ethanol (1mg/ml), methanol (1mg/ml), DMSO (10mg/ml), DMF (10mg/ml)
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at +4°C.
      Long Term Storage
      +4°C
      Short Term Storage
      +4°C
      Shipping
      AMBIENT
      Transportation
      Packing Group III
      RIDADR
      UN 3077 9
      Signal word
      Danger
      GHS Symbol
      GHS05+GHS07+GHS09
      Precautionary statements
      P261-P273-P280-P305 + P351 + P338
      Hazard statements
      H315-H318-H335-H411
      Description
      Magnolol is a bioactive compound isolated from the bark of M. officinalis that has been used in Asian traditional medicine for the treatment of anxiety, sleep disorders, and allergic diseases. Magnolol is an antifungal, antibacterial and antioxidant compound. It demonstrates anti-inflammatory activity by interferring with NF-?B signalling and NLRP3 inhibition. Magnolol can activate cannabinoid (CB) receptors, behaving as a partial agonist with selectivity for the peripheral CB2 subtype versus central CB1. It been identified as modulators of the GABAA receptors in vitro. It is a potent antitumor and antiangiogenic compound. Shown to inhibit HIF-1alpha/VEGF signalling, inhibiting invasion and metastasis through MMP2/MMP9 and inhibiting microtubule polymerization. Induces apoptosis through EGFR/PI3K/Akt pathway. Shows anti-diabetic/anti-obesity activity targeting nuclear receptors retinoic X receptor alpha (RXRalpha) and peroxisome proliferator activated receptor γ (PPARγ). In addition promotes thermogenesis.
      References
      (1) K. Watanabe, et al., Planta Med. 49, 103 (1983) , (2) J.P. Wang, et al., Naunyn Schmiedebergs Arch. Pharmacol. 346, 707 (1992) , (3) Y. Maruyama, et al., J. Nat. Prod. 61, 135 (1998) , (4) K.H. Bang, et al., Arch. Pharm. Res. 23, 46 (2000) , (5) K.Y. Ho, et al., Phytother. Res. 15, 139 (2001) , (6) J. Ai, et al., Pharmacology 63, 34 (2001) , (7) K. Ikeda & H. Nagase, Biol. Pharm. Bull. 25, 1546 (2002) , (8) K. Ikeda, et al., Phytother. Res. 17, 933 (2003) , (9) J. Park, et al., Eur. J. Pharmacol. 496, 189 (2004) , (10) A.K. Tse, et al., Mol. Immunol. 44, 2647 (2007) , (11) D.H. Lee, et al., J. Cell Biochem. 106, 1113 (2009) , (12) E.S. Hwang & K.K. Park, Biosci. Biotechnol. Biochem. 74, 961 (2010) , (13) H. Zhang, et al., PLoS One 6, e28253 (2011) , (14) V. Rempel, et al., ACS Med. Chem. Lett. 4, 41 (2013) , (15) M.C. Chen, et al., Biochem. Pharmacol. 85, 1278 (2013) , (16) Y. Sakaue, et al., Microbiol. Immunol. 60, 10 (2016) , (17) J. Shen, et al., Cell Physiol. Biochem. 42, 1789 (2017) , (18) F. Huang, et al., Mol. Med. Rep. 16, 4817 (2017) , (19) H.A. Parray, et al., Nutrition 50, 82 (2018)
      InChi Key
      VVOAZFWZEDHOOU-UHFFFAOYSA-N
      Smiles
      OC1=CC=C(CC=C)C=C1C2=CC(CC=C)=CC=C2O

      Magnolol is a bioactive compound isolated from the bark of M. officinalis that has been used in Asian traditional medicine for the treatment of anxiety, sleep disorders, and allergic diseases. Magnolol is an antifungal, antibacterial and antioxidant compound. It demonstrates anti-inflammatory activity by interferring with NF-?B signalling and NLRP3 inhibition. Magnolol can activate cannabinoid (CB) receptors, behaving as a partial agonist with selectivity for the peripheral CB2 subtype versus central CB1. It been identified as modulators of the GABAA receptors in vitro. It is a potent antitumor and antiangiogenic compound. Shown to inhibit HIF-1alpha/VEGF signalling, inhibiting invasion and metastasis through MMP2/MMP9 and inhibiting microtubule polymerization. Induces apoptosis through EGFR/PI3K/Akt pathway. Shows anti-diabetic/anti-obesity activity targeting nuclear receptors retinoic X receptor alpha (RXRalpha) and peroxisome proliferator activated receptor γ (PPARγ). In addition promotes thermogenesis.

      SKU: M0170 Category: Phytochemicals
      • Additional information

      Additional information

      Synonyms

      5,5'-Diallyl-2,2'-biphenyldiol, NSC 293099

      Purity

      ≥98% (HPLC)

      Appearance

      White to off-white powder

      CAS-Number

      528-43-8

      Molecular Formula

      C18H18O2

      Molecular Weight

      266.33

      Identity

      1H-NMR

      Solvents

      ethanol (1mg/ml), methanol (1mg/ml), DMSO (10mg/ml), DMF (10mg/ml)

      Melting Point

      101 – 102 °C

      Smiles

      OC1=CC=C(CC=C)C=C1C2=CC(CC=C)=CC=C2O

      InChi Key

      VVOAZFWZEDHOOU-UHFFFAOYSA-N

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      +4°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at +4°C.

      Hazard statements

      H315-H318-H335-H411

      Precautionary statements

      P261-P273-P280-P305 + P351 + P338

      GHS Symbol

      GHS05+GHS07+GHS09

      Signal word

      Danger

      RIDADR

      UN 3077 9

      Transportation

      Packing Group III

      References

      (1) K. Watanabe, et al., Planta Med. 49, 103 (1983), (2) J.P. Wang, et al., Naunyn Schmiedebergs Arch. Pharmacol. 346, 707 (1992), (3) Y. Maruyama, et al., J. Nat. Prod. 61, 135 (1998), (4) K.H. Bang, et al., Arch. Pharm. Res. 23, 46 (2000), (5) K.Y. Ho, et al., Phytother. Res. 15, 139 (2001), (6) J. Ai, et al., Pharmacology 63, 34 (2001), (7) K. Ikeda & H. Nagase, Biol. Pharm. Bull. 25, 1546 (2002), (8) K. Ikeda, et al., Phytother. Res. 17, 933 (2003), (9) J. Park, et al., Eur. J. Pharmacol. 496, 189 (2004), (10) A.K. Tse, et al., Mol. Immunol. 44, 2647 (2007), (11) D.H. Lee, et al., J. Cell Biochem. 106, 1113 (2009), (12) E.S. Hwang & K.K. Park, Biosci. Biotechnol. Biochem. 74, 961 (2010), (13) H. Zhang, et al., PLoS One 6, e28253 (2011), (14) V. Rempel, et al., ACS Med. Chem. Lett. 4, 41 (2013), (15) M.C. Chen, et al., Biochem. Pharmacol. 85, 1278 (2013), (16) Y. Sakaue, et al., Microbiol. Immunol. 60, 10 (2016), (17) J. Shen, et al., Cell Physiol. Biochem. 42, 1789 (2017), (18) F. Huang, et al., Mol. Med. Rep. 16, 4817 (2017), (19) H.A. Parray, et al., Nutrition 50, 82 (2018)

      Quantity

      10 mg, Bulk

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