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Mildronate dihydrate

SKU: M0558

Categories:

Synonyms: Meldonium , MET 88 , Quaterin , THP; 86426-17-7
CAS-Number: C₆H₁₄N₂O₂ . ₂H₂O
Molecular Formula: 182.22
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: White to off-white powder
Identity: 1H-NMR

Properties

Solvents: water (20 mg/ml), ethanol (20 mg/ml)

Shipping: AMBIENT
Short Term Storage: +4°C
Long Term Storage: -20°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.

Hazard statements: H315-H319-H335
Precautionary statements: P261-P305 + P351 + P338
GHS Symbol: GHS07
Signal word: Warning
Transportation: Packing Group III

Description: Mildronate is a structural analog of γ,-butyrobetaine (γ,BB), an intermediate in the biosynthesis of carnitine and a modulator of energy metabolism. It blocks carnitine synthesis by inhibiting γ,BB hydroxylase (BBOX) and, less potently, carnitine acetyltransferase (CrAT). Through these actions, mildronate reduces the levels of free carnitine and long chain acyl carnitine. This leads to suppressed fatty acid metabolism and mitochondrial uncoupling during oxidative conditions, resulting in cardioprotective, antidiabetic and neuroprotective effects. Mildronate also improves cognition and reduces amyloid-β, pathology in a mouse model of Alzheimer’s disease.
Smiles: [O-]C(CCN[N+](C)(C)C)=O
InChi Key: PVBQYTCFVWZSJK-UHFFFAOYSA-N
References: (1) B.Z. Simkhovich, et al., Biochem. Pharmacol. 37, 195 (1988) , (2) M. Dambrova, et al., Trends Cardiovasc. Med. 12, 275 (2002) (Review) , (3) E. Liepinsh, et al., J. Cardiovasc. Pharmacol. 48, 314 (2006) , (4) R. Vilskersts, et al., Pharmacology 83, 287 (2009) , (5) K. Jaudzems, et al., J. Enzyme Inhib. Med. Chem. 24, 1269 (2009) , (6) J. Pupure, et al., Neurosci. Lett. 470, 100 (2010) , (7) V.Z. Klusa, et al., Int. J. Mol. Sci. 11, 4465 (2010) , (8) I.K. Leung, et al., Chem. Biol. 17, 1316 (2010) , (9) E. Liepinsh, et al., Eur. J. Pharmacol. 658, 277 (2011) , (10) K. Tars, et al., J. Med. Chem. 57, 2213 (2014) , (11) U. Beitnere, et al., J. Neurosci. Res. 92, 338 (2014) , (12) M. Makrecka, et al., Eur. J. Pharmacol. 723, 55 (2014)
InChi: InChI=1S/C6H14N2O2/c1-8(2,3)7-5-4-6(9)10/h7H,4-5H2,1-3H3

Mildronate is a structural analog of γ,-butyrobetaine (γ,BB), an intermediate in the biosynthesis of carnitine and a modulator of energy metabolism. It blocks carnitine synthesis by inhibiting γ,BB hydroxylase (BBOX) and, less potently, carnitine acetyltransferase (CrAT). Through these actions, mildronate reduces the levels of free carnitine and long chain acyl carnitine. This leads to suppressed fatty acid metabolism and mitochondrial uncoupling during oxidative conditions, resulting in cardioprotective, antidiabetic and neuroprotective effects. Mildronate also improves cognition and reduces amyloid-β, pathology in a mouse model of Alzheimer’s disease.

SKU: M0558

Additional information

Additional information

Synonyms	Meldonium, MET 88, Quaterin, THP
Purity	≥98% (HPLC)
Appearance	White to off-white powder
CAS-Number	86426-17-7
Molecular Formula	C6H14N2O2 . 2H2O
Molecular Weight	182.22
Identity	1H-NMR
Solvents	water (20 mg/ml), ethanol (20 mg/ml)
Smiles	[O-]C(CCN[N+](C)(C)C)=O
InChi Key	PVBQYTCFVWZSJK-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305 + P351 + P338
GHS Symbol	GHS07
Signal word	Warning
Transportation	Packing Group III
References	(1) B.Z. Simkhovich, et al., Biochem. Pharmacol. 37, 195 (1988), (2) M. Dambrova, et al., Trends Cardiovasc. Med. 12, 275 (2002) (Review), (3) E. Liepinsh, et al., J. Cardiovasc. Pharmacol. 48, 314 (2006), (4) R. Vilskersts, et al., Pharmacology 83, 287 (2009), (5) K. Jaudzems, et al., J. Enzyme Inhib. Med. Chem. 24, 1269 (2009), (6) J. Pupure, et al., Neurosci. Lett. 470, 100 (2010), (7) V.Z. Klusa, et al., Int. J. Mol. Sci. 11, 4465 (2010), (8) I.K. Leung, et al., Chem. Biol. 17, 1316 (2010), (9) E. Liepinsh, et al., Eur. J. Pharmacol. 658, 277 (2011), (10) K. Tars, et al., J. Med. Chem. 57, 2213 (2014), (11) U. Beitnere, et al., J. Neurosci. Res. 92, 338 (2014), (12) M. Makrecka, et al., Eur. J. Pharmacol. 723, 55 (2014)
InChi	InChI=1S/C6H14N2O2/c1-8(2,3)7-5-4-6(9)10/h7H,4-5H2,1-3H3
Quantity	10 mg, 25 mg, Bulk