Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- water (20 mg/ml), ethanol (20 mg/ml)
Mildronate is a structural analog of γ,-butyrobetaine (γ,BB), an intermediate in the biosynthesis of carnitine and a modulator of energy metabolism. It blocks carnitine synthesis by inhibiting γ,BB hydroxylase (BBOX) and, less potently, carnitine acetyltransferase (CrAT). Through these actions, mildronate reduces the levels of free carnitine and long chain acyl carnitine. This leads to suppressed fatty acid metabolism and mitochondrial uncoupling during oxidative conditions, resulting in cardioprotective, antidiabetic and neuroprotective effects. Mildronate also improves cognition and reduces amyloid-β, pathology in a mouse model of Alzheimer’s disease.
Synonyms | Meldonium, MET 88, Quaterin, THP |
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Purity | ≥98% (HPLC) |
Appearance | White to off-white powder |
CAS-Number | 86426-17-7 |
Molecular Formula | C6H14N2O2 . 2H2O |
Molecular Weight | 182.22 |
Identity | 1H-NMR |
Solvents | water (20 mg/ml), ethanol (20 mg/ml) |
Smiles | [O-]C(CCN[N+](C)(C)C)=O |
InChi Key | PVBQYTCFVWZSJK-UHFFFAOYSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Hazard statements | H315-H319-H335 |
Precautionary statements | P261-P305 + P351 + P338 |
GHS Symbol | GHS07 |
Signal word | Warning |
Transportation | Packing Group III |
References | (1) B.Z. Simkhovich, et al., Biochem. Pharmacol. 37, 195 (1988), (2) M. Dambrova, et al., Trends Cardiovasc. Med. 12, 275 (2002) (Review), (3) E. Liepinsh, et al., J. Cardiovasc. Pharmacol. 48, 314 (2006), (4) R. Vilskersts, et al., Pharmacology 83, 287 (2009), (5) K. Jaudzems, et al., J. Enzyme Inhib. Med. Chem. 24, 1269 (2009), (6) J. Pupure, et al., Neurosci. Lett. 470, 100 (2010), (7) V.Z. Klusa, et al., Int. J. Mol. Sci. 11, 4465 (2010), (8) I.K. Leung, et al., Chem. Biol. 17, 1316 (2010), (9) E. Liepinsh, et al., Eur. J. Pharmacol. 658, 277 (2011), (10) K. Tars, et al., J. Med. Chem. 57, 2213 (2014), (11) U. Beitnere, et al., J. Neurosci. Res. 92, 338 (2014), (12) M. Makrecka, et al., Eur. J. Pharmacol. 723, 55 (2014) |
InChi | InChI=1S/C6H14N2O2/c1-8(2,3)7-5-4-6(9)10/h7H,4-5H2,1-3H3 |
Quantity | 10 mg, 25 mg, Bulk |