Moxidectin

Available from stock

Moxidectin

SKU
M0188

Category:

Synonyms
23-Methoxime-LL-F 28249α , CL 301423
113507-06-5
CAS-Number
C37H53NO8
Molecular Formula
639.82
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Specifications

Purity
EP
Appearance
Yellow powder
Identity
1H-NMR

Properties

Solvents
DMSO, ethanol, DMF (all 20 mg/ml)
Shipping
AMBIENT
Short Term Storage
+4°C
Long Term Storage
-20°C
Handling Advice
Protect from light and moisture.
Use / Stability
Stable for at least 2 years after receipt when stored at -20°C.
Hazard statements
H301-H400
GHS Symbol
GHS06+GHS09
Signal word
Danger
RIDADR
UN2811
Transportation
Packing Group II
Description
Moxidectin is broad-spectrum antiparasitic agent used in animals to prevent or control parasitic worms (helminths), such as heartworm and intestinal worms, in dogs, cats, horses, cattle and sheep. Moxidectin kills some of the most common internal and external parasites by selectively binding to a parasite's glutamate-gated chloride ion channels. These channels are vital to the function of invertebrate nerve and muscle cells. When moxidectin binds to the channels, it disrupts neurotransmission, resulting in paralysis and death of the parasite. Moxidectin selectively enhanced the tonic GABA conductance of hippocampal pyramidal neurons in rats. Moxidectin is also used in the treatment of onchocerciasis, against acaricides/miticides, as well as in the prevention and treatment of other parasitic infections in veterinary medicine. Moxidectin belongs to the milbemycin familyand is similar to avermectins in terms of chemical strucutre. It might have some antitumor and multidrug resistance properties.
Smiles
O[C@]1([C@](C=C2C)([H])C(O[C@](C3)([H])C4)=O)[C@]([C@@H]2O)([H])OC/C1=CC=C[C@H](C)C/C(C)=C/C[C@@]3([H])O[C@]4(C/5)O[C@H](/C(C)=C/C(C)C)[C@@H](C)C5=NOC
InChi Key
YZBLFMPOMVTDJY-LSGXYNIPSA-N
References
(1) S. Ranjan, et al., Vet. Parasitol. 41, 227 (1992) , (2) C. Menez, et al., PLoS Negl. Trop. Dis. 6, e1883 (2012) , (3) J. Spampanato, et al., J. Neurophysiol. 119, 1693 (2018) , (4) D. Song, et al., Oncol. Rep. 40, 1348 (2018) , (5) B. Getachew & Y. Tizabi, Behav. Brain Res. 376, 112220 (2019) , (6) M. Sharaf, et al., Exp. Parasitol. (epub ahead of print) (2020)
InChi
InChI=1S/C37H53NO8/c1-21(2)14-25(6)33-26(7)31(38-42-8)19-36(46-33)18-29-17-28(45-36)13-12-23(4)15-22(3)10-9-11-27-20-43-34-32(39)24(5)16-30(35(40)44-29)37(27,34)41/h9-12,14,16,21-22,26,28-30,32-34,39,41H,13,15,17-20H2,1-8H3/b10-9+,23-12+,25-14+,27-11+,38-31+/t22-,26-,28+,29-,30-,32+,33+,34+,36-,37+/m0/s1

Moxidectin is broad-spectrum antiparasitic agent used in animals to prevent or control parasitic worms (helminths), such as heartworm and intestinal worms, in dogs, cats, horses, cattle and sheep. Moxidectin kills some of the most common internal and external parasites by selectively binding to a parasite’s glutamate-gated chloride ion channels. These channels are vital to the function of invertebrate nerve and muscle cells. When moxidectin binds to the channels, it disrupts neurotransmission, resulting in paralysis and death of the parasite. Moxidectin selectively enhanced the tonic GABA conductance of hippocampal pyramidal neurons in rats. Moxidectin is also used in the treatment of onchocerciasis, against acaricides/miticides, as well as in the prevention and treatment of other parasitic infections in veterinary medicine. Moxidectin belongs to the milbemycin familyand is similar to avermectins in terms of chemical strucutre. It might have some antitumor and multidrug resistance properties.

SKU: M0188 Category:

Additional information

Synonyms

23-Methoxime-LL-F 28249α, CL 301423
Purity

EP
Appearance

Yellow powder
CAS-Number

113507-06-5
Molecular Formula

C37H53NO8
Molecular Weight

639.82
Identity

1H-NMR
Solvents

DMSO, ethanol, DMF (all 20 mg/ml)
Smiles

O[C@]1([C@](C=C2C)([H])C(O[C@](C3)([H])C4)=O)[C@]([C@@H]2O)([H])OC/C1=CC=C[C@H](C)C/C(C)=C/C[C@@]3([H])O[C@]4(C/5)O[C@H](/C(C)=C/C(C)C)[C@@H](C)C5=NOC
InChi Key

YZBLFMPOMVTDJY-LSGXYNIPSA-N
Shipping

AMBIENT
Short Term Storage

+4°C
Long Term Storage

-20°C
Handling Advice

Protect from light and moisture.
Use / Stability

Stable for at least 2 years after receipt when stored at -20°C.
Hazard statements

H301-H400
GHS Symbol

GHS06+GHS09
Signal word

Danger
RIDADR

UN2811
Transportation

Packing Group II
References

(1) S. Ranjan, et al., Vet. Parasitol. 41, 227 (1992), (2) C. Menez, et al., PLoS Negl. Trop. Dis. 6, e1883 (2012), (3) J. Spampanato, et al., J. Neurophysiol. 119, 1693 (2018), (4) D. Song, et al., Oncol. Rep. 40, 1348 (2018), (5) B. Getachew & Y. Tizabi, Behav. Brain Res. 376, 112220 (2019), (6) M. Sharaf, et al., Exp. Parasitol. (epub ahead of print) (2020)
InChi

InChI=1S/C37H53NO8/c1-21(2)14-25(6)33-26(7)31(38-42-8)19-36(46-33)18-29-17-28(45-36)13-12-23(4)15-22(3)10-9-11-27-20-43-34-32(39)24(5)16-30(35(40)44-29)37(27,34)41/h9-12,14,16,21-22,26,28-30,32-34,39,41H,13,15,17-20H2,1-8H3/b10-9+,23-12+,25-14+,27-11+,38-31+/t22-,26-,28+,29-,30-,32+,33+,34+,36-,37+/m0/s1
Quantity

25 mg, Bulk

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