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    Moxifloxacin hydrochloride

    Available from stock

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      Moxifloxacin hydrochloride

      SKU
      M0189

      Category: Antibiotics

      Synonyms
      BAY 12-8039 , Alelox , 1-Cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydropyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
      186826-86-8
      CAS-Number
      C21H24FN3O4· HCl
      Molecular Formula
      401.43 . 36.46
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥97% (NMR)
      Identity
      1H-NMR
      Appearance
      Light yellow powder

      Properties

      Solvents
      DMSO (10 mg/ml), water (5 mg/ml)
      Short Term Storage
      +4°C
      Use / Stability
      Stable for at least 2 years after receipt when stored at -20°C.
      Handling Advice
      Protect from light and moisture.
      Long Term Storage
      -20°C
      Shipping
      AMBIENT
      Transportation
      Not dangerous goods
      Description
      Moxifloxacin is a fourth-generation synthetic broad-spectrum fluoroquinolone antibiotic. It is used against both Gram-positive and Gram-negative bacteria and to treat bacterial infections associated with bronchitis, sinusitis, and other conditions. Fluoroquinolones stabilize DNA strand breaks created by DNA gyrase (Topo II) and topoisomerase IV by binding to the enzyme-DNA complex. Compared to mammalian DNA gyrase, moxifloxacin has 100 times higher affinity for bacterial DNA gyrase. Can also be used as reference compound.
      InChi
      InChI=1S/C21H24FN3O4.ClH/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24 , /h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28) , 1H/t11-,16+ , /m0./s1
      References
      (1) M. Souli, et al., Int. J. Antimicrob. Agents. 10, 23 (1998) , (2) C. Ballow, et al., Clin. Ther. 21, 513 (1999) , (3) A. Dalhoff, et al., Clin. Infect. Dis. 32, S22 (2001) , (4) R. Kishii, et al., Antimicrob. Agents Chemother. 47, 77 (2003) , (5) M. Miravitlles, J. Chron. Obstruct. Pulmon. Dis. 2, 191 (2007) , (6) M. Miravitlles & A. Anzueto, Expert Opin. Pharmacother. 9, 1755 (2008) (Review) , (7) H. Takiff & E. Guerrero, Antimicrob. Agents Chemother. 55, 5421 (2011) , (8) M.M. Al Omari, et al., Profiles Drug Subst. Excip. Relat. Methodol. 39, 299 (2014) (Review)
      InChi Key
      IDIIJJHBXUESQI-DFIJPDEKSA-N
      Smiles
      O=C1C(C(O)=O)=CN(C2CC2)C3=C(OC)C([NH+]4C[C@](NCCC5)([H])[C@]5([H])C4)=C(F)C=C31.[Cl-]

      Moxifloxacin is a fourth-generation synthetic broad-spectrum fluoroquinolone antibiotic. It is used against both Gram-positive and Gram-negative bacteria and to treat bacterial infections associated with bronchitis, sinusitis, and other conditions. Fluoroquinolones stabilize DNA strand breaks created by DNA gyrase (Topo II) and topoisomerase IV by binding to the enzyme-DNA complex. Compared to mammalian DNA gyrase, moxifloxacin has 100 times higher affinity for bacterial DNA gyrase. Can also be used as reference compound.

      SKU: M0189 Category: Antibiotics
      • Additional information

      Additional information

      Synonyms

      BAY 12-8039, Alelox, 1-Cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydropyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride

      Purity

      ≥97% (NMR)

      Appearance

      Light yellow powder

      CAS-Number

      186826-86-8

      Molecular Formula

      C21H24FN3O4· HCl

      Molecular Weight

      401.43 . 36.46

      Identity

      1H-NMR

      Solvents

      DMSO (10 mg/ml), water (5 mg/ml)

      Smiles

      O=C1C(C(O)=O)=CN(C2CC2)C3=C(OC)C([NH+]4C[C@](NCCC5)([H])[C@]5([H])C4)=C(F)C=C31.[Cl-]

      InChi Key

      IDIIJJHBXUESQI-DFIJPDEKSA-N

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      -20°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at -20°C.

      Transportation

      Not dangerous goods

      References

      (1) M. Souli, et al., Int. J. Antimicrob. Agents. 10, 23 (1998), (2) C. Ballow, et al., Clin. Ther. 21, 513 (1999), (3) A. Dalhoff, et al., Clin. Infect. Dis. 32, S22 (2001), (4) R. Kishii, et al., Antimicrob. Agents Chemother. 47, 77 (2003), (5) M. Miravitlles, J. Chron. Obstruct. Pulmon. Dis. 2, 191 (2007), (6) M. Miravitlles & A. Anzueto, Expert Opin. Pharmacother. 9, 1755 (2008) (Review), (7) H. Takiff & E. Guerrero, Antimicrob. Agents Chemother. 55, 5421 (2011), (8) M.M. Al Omari, et al., Profiles Drug Subst. Excip. Relat. Methodol. 39, 299 (2014) (Review)

      InChi

      InChI=1S/C21H24FN3O4.ClH/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24, /h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28), 1H/t11-,16+, /m0./s1

      Quantity

      50 mg, Bulk

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