Moxifloxacin hydrochloride

SKU: M0189

Category: Antibiotics

Synonyms: BAY 12-8039 , Alelox , 1-Cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydropyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride; 186826-86-8
CAS-Number: C₂₁H₂₄FN₃O₄· HCl
Molecular Formula: 401.43 . 36.46
Molecular Weight

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥97% (NMR)
Identity: 1H-NMR
Appearance: Light yellow powder

Properties

Solvents: DMSO (10 mg/ml), water (5 mg/ml)

Short Term Storage: +4°C
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.
Handling Advice: Protect from light and moisture.
Long Term Storage: -20°C
Shipping: AMBIENT

Transportation: Not dangerous goods

Description: Moxifloxacin is a fourth-generation synthetic broad-spectrum fluoroquinolone antibiotic. It is used against both Gram-positive and Gram-negative bacteria and to treat bacterial infections associated with bronchitis, sinusitis, and other conditions. Fluoroquinolones stabilize DNA strand breaks created by DNA gyrase (Topo II) and topoisomerase IV by binding to the enzyme-DNA complex. Compared to mammalian DNA gyrase, moxifloxacin has 100 times higher affinity for bacterial DNA gyrase. Can also be used as reference compound.
InChi: InChI=1S/C21H24FN3O4.ClH/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24 , /h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28) , 1H/t11-,16+ , /m0./s1
References: (1) M. Souli, et al., Int. J. Antimicrob. Agents. 10, 23 (1998) , (2) C. Ballow, et al., Clin. Ther. 21, 513 (1999) , (3) A. Dalhoff, et al., Clin. Infect. Dis. 32, S22 (2001) , (4) R. Kishii, et al., Antimicrob. Agents Chemother. 47, 77 (2003) , (5) M. Miravitlles, J. Chron. Obstruct. Pulmon. Dis. 2, 191 (2007) , (6) M. Miravitlles & A. Anzueto, Expert Opin. Pharmacother. 9, 1755 (2008) (Review) , (7) H. Takiff & E. Guerrero, Antimicrob. Agents Chemother. 55, 5421 (2011) , (8) M.M. Al Omari, et al., Profiles Drug Subst. Excip. Relat. Methodol. 39, 299 (2014) (Review)
InChi Key: IDIIJJHBXUESQI-DFIJPDEKSA-N
Smiles: O=C1C(C(O)=O)=CN(C2CC2)C3=C(OC)C([NH+]4C[C@](NCCC5)([H])[C@]5([H])C4)=C(F)C=C31.[Cl-]

Moxifloxacin is a fourth-generation synthetic broad-spectrum fluoroquinolone antibiotic. It is used against both Gram-positive and Gram-negative bacteria and to treat bacterial infections associated with bronchitis, sinusitis, and other conditions. Fluoroquinolones stabilize DNA strand breaks created by DNA gyrase (Topo II) and topoisomerase IV by binding to the enzyme-DNA complex. Compared to mammalian DNA gyrase, moxifloxacin has 100 times higher affinity for bacterial DNA gyrase. Can also be used as reference compound.

SKU: M0189 Category: Antibiotics

Additional information

Additional information

Synonyms	BAY 12-8039, Alelox, 1-Cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydropyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
Purity	≥97% (NMR)
Appearance	Light yellow powder
CAS-Number	186826-86-8
Molecular Formula	C21H24FN3O4· HCl
Molecular Weight	401.43 . 36.46
Identity	1H-NMR
Solvents	DMSO (10 mg/ml), water (5 mg/ml)
Smiles	O=C1C(C(O)=O)=CN(C2CC2)C3=C(OC)C([NH+]4C[C@](NCCC5)([H])[C@]5([H])C4)=C(F)C=C31.[Cl-]
InChi Key	IDIIJJHBXUESQI-DFIJPDEKSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Transportation	Not dangerous goods
References	(1) M. Souli, et al., Int. J. Antimicrob. Agents. 10, 23 (1998), (2) C. Ballow, et al., Clin. Ther. 21, 513 (1999), (3) A. Dalhoff, et al., Clin. Infect. Dis. 32, S22 (2001), (4) R. Kishii, et al., Antimicrob. Agents Chemother. 47, 77 (2003), (5) M. Miravitlles, J. Chron. Obstruct. Pulmon. Dis. 2, 191 (2007), (6) M. Miravitlles & A. Anzueto, Expert Opin. Pharmacother. 9, 1755 (2008) (Review), (7) H. Takiff & E. Guerrero, Antimicrob. Agents Chemother. 55, 5421 (2011), (8) M.M. Al Omari, et al., Profiles Drug Subst. Excip. Relat. Methodol. 39, 299 (2014) (Review)
InChi	InChI=1S/C21H24FN3O4.ClH/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24, /h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28), 1H/t11-,16+, /m0./s1
Quantity	50 mg, Bulk