Available from stock

Naproxen solution 1.0 mg/ml in methanol

SKU: N0258

Category: API's & Intermediates

Synonyms: (S)-Naproxen , (+)-Naproxen , (S)-(+)-6-Methoxy-α-methyl-2-naphthalene acetic acid , Equiproxen , Laraflex; 22204-53-1
CAS-Number: C₁₄H₁₄O₃
Molecular Formula: 230.26
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: Liquid
Identity: 1H-NMR
Concentration: 1.0 mg/ml in methanol

Properties

Solvents: aqueous buffers

Shipping: AMBIENT
Short Term Storage: +4°C
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Hazard statements: H225-H301 + H311 + H331-H370
Precautionary statements: P210-P260-P280-P301 + P310-P311
GHS Symbol: GHS02+GHS06
Signal word: Danger
RIDADR: UN1230 3
Transportation: Packing Group III

Description: Naproxen is a potent, non-steroidal, non-selective anti-inflammatory cyclooxygenase (COX-1 and COX-2) inhibitor. Inhibits COX-1 expression in HUVECS at a concentration of 5µg/ml. This COX inhibitor is indicated for the treatment of pain, fever, inflammation and stiffness. Research indicates that the S-naproxen is a more active form than the R-naproxen. The S-naproxen enantiomer was observed to inhibit platelet aggregation, and both enantiomers decrease production of thromboxane B2. Naproxen has been demonstrated to block Aβ fibril growth and form a complex with copper (II).
Smiles: C[C@H](C(O)=O)C1=CC2=CC=C(OC)C=C2C=C1
InChi Key: CMWTZPSULFXXJA-VIFPVBQESA-N
References: (1) W.F. Kean, et al., J. Pharm. Sci. 78, 324 (1989) , (2) T. Zyglewska, et al., Biochim. Biophys. Acta 1131, 78 (1992) , (3) J. Barnett, et al., Biochim. Biophys. Acta 1209, 130 (1994) , (4) O. Laneuville, et al., J. Pharmacol. Exp. Ther. 271, 927 (1994) , (5) N.M. Davies & K.E. Anderson, Clin. Pharmacokinet. 32, 268 (1997) , (6) N. Monck, IDrugs 6, 593 (2003) , (7) T. Takeda, et al., J. Phys. Chem. B. 114, 15394 (2010) , (8) K.C. Duggan, et al., J. Biol. Chem. 285, 34950 (2010)
InChi: InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)

Naproxen is a potent, non-steroidal, non-selective anti-inflammatory cyclooxygenase (COX-1 and COX-2) inhibitor. Inhibits COX-1 expression in HUVECS at a concentration of 5µg/ml. This COX inhibitor is indicated for the treatment of pain, fever, inflammation and stiffness. Research indicates that the S-naproxen is a more active form than the R-naproxen. The S-naproxen enantiomer was observed to inhibit platelet aggregation, and both enantiomers decrease production of thromboxane B2. Naproxen has been demonstrated to block Aβ fibril growth and form a complex with copper (II).

SKU: N0258 Category: API's & Intermediates

Additional information

Additional information

Synonyms	(S)-Naproxen, (+)-Naproxen, (S)-(+)-6-Methoxy-α-methyl-2-naphthalene acetic acid, Equiproxen, Laraflex
Purity	≥98% (HPLC)
Appearance	Liquid
CAS-Number	22204-53-1
Molecular Formula	C14H14O3
Molecular Weight	230.26
Identity	1H-NMR
Solvents	aqueous buffers
Smiles	C[C@H](C(O)=O)C1=CC2=CC=C(OC)C=C2C=C1
InChi Key	CMWTZPSULFXXJA-VIFPVBQESA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements	H225-H301 + H311 + H331-H370
Precautionary statements	P210-P260-P280-P301 + P310-P311
GHS Symbol	GHS02+GHS06
Signal word	Danger
RIDADR	UN1230 3
Transportation	Packing Group III
References	(1) W.F. Kean, et al., J. Pharm. Sci. 78, 324 (1989), (2) T. Zyglewska, et al., Biochim. Biophys. Acta 1131, 78 (1992), (3) J. Barnett, et al., Biochim. Biophys. Acta 1209, 130 (1994), (4) O. Laneuville, et al., J. Pharmacol. Exp. Ther. 271, 927 (1994), (5) N.M. Davies & K.E. Anderson, Clin. Pharmacokinet. 32, 268 (1997), (6) N. Monck, IDrugs 6, 593 (2003), (7) T. Takeda, et al., J. Phys. Chem. B. 114, 15394 (2010), (8) K.C. Duggan, et al., J. Biol. Chem. 285, 34950 (2010)
InChi	InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)
Quantity	5 ml, Bulk
cdx-Concentration	1.0 mg/ml in methanol