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    NBD-X SE

    Available from stock

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      NBD-X SE

      SKU
      N0045

      Category: Fluorescent Detection

      Synonyms
      NBD-X, SE , NBD-X N-succinimidyl ester , NBD-C6 SE , 6-(7-Nitrobenzofurazan-4-ylamino)hexanoic acid NHS ester
      145195-58-0
      CAS-Number
      C16H17N5O7
      Molecular Formula
      391.33
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥98% (HPLC)
      Identity
      1H-NMR
      Appearance
      Orange powder

      Properties

      Solvents
      DMSO, DMF
      Short Term Storage
      +4°C
      Use / Stability
      Stable for at least 2 years after receipt when stored at -20°C.
      Handling Advice
      Protect from light and moisture.
      Long Term Storage
      -20°C
      Shipping
      AMBIENT
      Transportation
      Not dangerous goods
      Description
      NBD-X, SE is an excellent amino-reactive building block that can be used to prepare peptide conjugates and other bioconjugates/biopolymers. It has much higher conjugation efficiency than NBD-Cl and NBD-F. This amine-reactive NBD derivative, containing a convenient succinimidyl ester, can be used to develop environmentally sensitive bioconjugates. NBD is a functional analog of the dinitrophenyl hapten, and its fluorescence is quenched upon binding to anti-dinitrophenyl (anti-DNP) antibodies. The X-spacer separates the fluorescent dye from the protein allowing greater sensitivity and reduced perturbation effects on protein labeling. Spectral properties: λEx=460, λEm=540.
      References
      (1) C. Sherrill, et al., Biochemistry 34, 3553 (1995) , (2) B.K. Nunnally, et al., Anal. Chem. 69, 2392 (1997) , (3) J.T. Elliott & G.D. Prestwich, Bioconjug. Chem. 11, 832 (2000) , (4) S. Ozaki, et al., PNAS 97, 11286 (2000) , (5) A. Karlstrom, et al., Anal. Biochem. 295, 22 (2001) , (6) F. Eisele, et al., Chem. Eur. J. 8, 3362 (2002) , (7) L. Silva, et al., J. Photochem. Photobiol. B 72, 17 (2003) , (8) J.M. Bergen, et al., Bioconjug. Chem. 19, 377 (2008)
      Smiles
      O=C(ON1C(CCC1=O)=O)CCCCCNC2=CC=C([N+]([O-])=O)C3=NON=C32

      NBD-X, SE is an excellent amino-reactive building block that can be used to prepare peptide conjugates and other bioconjugates/biopolymers. It has much higher conjugation efficiency than NBD-Cl and NBD-F. This amine-reactive NBD derivative, containing a convenient succinimidyl ester, can be used to develop environmentally sensitive bioconjugates. NBD is a functional analog of the dinitrophenyl hapten, and its fluorescence is quenched upon binding to anti-dinitrophenyl (anti-DNP) antibodies. The X-spacer separates the fluorescent dye from the protein allowing greater sensitivity and reduced perturbation effects on protein labeling. Spectral properties: λEx=460, λEm=540.

      SKU: N0045 Category: Fluorescent Detection
      • Additional information

      Additional information

      Synonyms

      NBD-X, SE, NBD-X N-succinimidyl ester, NBD-C6 SE, 6-(7-Nitrobenzofurazan-4-ylamino)hexanoic acid NHS ester

      Purity

      ≥98% (HPLC)

      Appearance

      Orange powder

      CAS-Number

      145195-58-0

      Molecular Formula

      C16H17N5O7

      Molecular Weight

      391.33

      Identity

      1H-NMR

      Solvents

      DMSO, DMF

      Smiles

      O=C(ON1C(CCC1=O)=O)CCCCCNC2=CC=C([N+]([O-])=O)C3=NON=C32

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      -20°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at -20°C.

      Transportation

      Not dangerous goods

      References

      (1) C. Sherrill, et al., Biochemistry 34, 3553 (1995), (2) B.K. Nunnally, et al., Anal. Chem. 69, 2392 (1997), (3) J.T. Elliott & G.D. Prestwich, Bioconjug. Chem. 11, 832 (2000), (4) S. Ozaki, et al., PNAS 97, 11286 (2000), (5) A. Karlstrom, et al., Anal. Biochem. 295, 22 (2001), (6) F. Eisele, et al., Chem. Eur. J. 8, 3362 (2002), (7) L. Silva, et al., J. Photochem. Photobiol. B 72, 17 (2003), (8) J.M. Bergen, et al., Bioconjug. Chem. 19, 377 (2008)

      Quantity

      25 mg, Bulk

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