Specifications
- Purity
- ≥98%
- Appearance
- Solid
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (2 mg/ml). Inwater.
Category: API's & Intermediates
Neratinib is a cell-permable, irreversible, selective inhibitor of the HER2 kinase (IC50=59nM) and EGFR (IC50=92nM) by preventing phosphorylation of these proteins by their respective kinases. It also potently inhibits several mutants of HER2 and shows 10-fold or greater selectivity over a wide variety of other kinases. As an irreversible inhibitor, neratinib may circumvent acquired resistance developed against reversible inhibitors, including gefitinib. Neratinib displays activity against a variety of cancer cell lines, including A431, 3T3, and MDA-MB-435. Neratinib has been evaluated in clinical trials against cancers characterized by HER2 overexpression or HER2 activating mutations.
Synonyms | HKI-272 |
---|---|
Purity | ≥98% |
Appearance | Solid |
CAS-Number | 698387-09-6 |
Molecular Formula | C30H29ClN6O3 |
Molecular Weight | 557 |
Identity | 1H-NMR |
Solvents | DMSO (2 mg/ml). Inwater. |
Smiles | CCOC1=C(NC(/C=C/CN(C)C)=O)C=C(C(NC2=CC(Cl)=C(OCC3=NC=CC=C3)C=C2)=C(C#N)C=N4)C4=C1 |
InChi Key | JWNPDZNEKVCWMY-VQHVLOKHSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Hazard statements | H361 |
Precautionary statements | P201, P202, P281, P308+313 |
GHS Symbol | GHS08 |
Signal word | Warning |
Transportation | Not dangerous goods |
References | (1) S.K. Rabindran, et al., Cancer Res. 64, 3958 (2004), (2) E.L. Kwak, et al., PNAS 102, 7665 (2005), (3) H. Ji, et al., PNAS 103, 7817 (2006), (4) P. Bose & H. Ozer, Expert. Opin. Investig. Drugs 18, 1735 (2009) (Review), (5) M.I. Davis, et al., Nat. Biotechnol. 29, 1046 (2011), (6) S.M. Kavuri, et al., Cancer Discov. 5, 832 (2015), (7) M. Segovia-Mendoza, et al., Am. J. Cancer Res. 5, 2531 (2015), (8) S.R. Tiwari, et al., Clin. Breast Cancer 16, 344 (2016) (Review) |
InChi | InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9-7+ |
Quantity | 50 mg, 100 mg, 250 mg, Bulk |