Specifications
- Purity
- ≥98% (NMR)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (20mg/ml), DMF (20mg/ml), ethanol (10mg/ml) or chloroform (50 mg/ml)
- Melting Point
- 42-43 °C (lit.)
Available from stock
Nervonic acid
- SKU
- N0171
Category: Lipids, Fatty Acids
- Synonyms
- FA 24:1, cis-15-Tetracosenoic acid, Selacholeic acid
- 506-37-6
- CAS-Number
- C24H46O2
- Molecular Formula
- 366.62
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- +4°C
- Long Term Storage
- -20°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Transportation
- Not dangerous goods
- Description
- Nervonic acid is a very long chain fatty acid. It is enriched in nervous tissue and is particularly abundant in sphingolipids, such as sphingomyelin in the myelin sheath of nerve fibers. This myelin sheath is essential for efficient nerve impulse transmission. Nervonic acid may play a role in brain development and neurodegenerative diseases. Nervonic acid is poorly produced in demyelinating disorders, including multiple sclerosis and adrenoleukodystrophy, suggesting that dietary supplementation may be beneficial. Nervonic acid also binds and inhibits DNA polymerase ? and HIV-1 reverse transcriptase.
- Smiles
- CCCCCCCC\C=C/CCCCCCCCCCCCCC(O)=O
- InChi Key
- GWHCXVQVJPWHRF-KTKRTIGZSA-N
- References
- (1) E.L. Hirvisalo & O. Renkonen, J. Lipid Res. 11, 54 (1970) , (2) J.R. Sargent, et al., Med. Hypotheses 42, 237 (1994) , (3) N. Kasai, et al., J. Biochem. 132, 819 (2002) , (4) D.C. Taylor, et al., Plant Biotechnol. J. 7, 925 (2009) , (5) Q. Li, et al., Food Chem. 301, 125286 (2019) (Review) , (6) N.V. Phung, et al., Ctir. Rev. Food Sci. Nutr. (2023) (Review) , (7) M. Namiecinska, et al., Int. J. Mol. Sci. 25, 3792 (2024) (Review)
- InChi
- InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/b10-9-
Nervonic acid is a very long chain fatty acid. It is enriched in nervous tissue and is particularly abundant in sphingolipids, such as sphingomyelin in the myelin sheath of nerve fibers. This myelin sheath is essential for efficient nerve impulse transmission. Nervonic acid may play a role in brain development and neurodegenerative diseases. Nervonic acid is poorly produced in demyelinating disorders, including multiple sclerosis and adrenoleukodystrophy, suggesting that dietary supplementation may be beneficial. Nervonic acid also binds and inhibits DNA polymerase ? and HIV-1 reverse transcriptase.
Additional information
| Synonyms | FA 24:1, cis-15-Tetracosenoic acid, Selacholeic acid |
|---|---|
| Purity | ≥98% (NMR) |
| Appearance | White to off-white powder |
| CAS-Number | 506-37-6 |
| Molecular Formula | C24H46O2 |
| Molecular Weight | 366.62 |
| Identity | 1H-NMR |
| Solvents | DMSO (20mg/ml), DMF (20mg/ml), ethanol (10mg/ml) or chloroform (50 mg/ml) |
| Melting Point | 42-43 °C (lit.) |
| Smiles | CCCCCCCC\C=C/CCCCCCCCCCCCCC(O)=O |
| InChi Key | GWHCXVQVJPWHRF-KTKRTIGZSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Transportation | Not dangerous goods |
| References | (1) E.L. Hirvisalo & O. Renkonen, J. Lipid Res. 11, 54 (1970), (2) J.R. Sargent, et al., Med. Hypotheses 42, 237 (1994), (3) N. Kasai, et al., J. Biochem. 132, 819 (2002), (4) D.C. Taylor, et al., Plant Biotechnol. J. 7, 925 (2009), (5) Q. Li, et al., Food Chem. 301, 125286 (2019) (Review), (6) N.V. Phung, et al., Ctir. Rev. Food Sci. Nutr. (2023) (Review), (7) M. Namiecinska, et al., Int. J. Mol. Sci. 25, 3792 (2024) (Review) |
| InChi | InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/b10-9- |
| Quantity | 100 mg, Bulk |
