Available from stock

New indocyanine green [IR-820]

SKU: N0516

Category: Reagents for Life Sciences

Synonyms: IR820 Dye; 172616-80-7
CAS-Number: C₄₆H₅₀ClN₂NaO₆S₂
Molecular Formula: 849.47
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: Green to red-brown powder
Identity: 1H-NMR

Properties

Solvents: Soluble in DMSO or methanol.
UV / Vis: 817 - 823 nm (c=0.005 g/l methanol)

Documentation

Safety Data Sheet (SDS): CDX N0516 MSDS.pdf

Shipping: AMBIENT
Short Term Storage: +4°C
Long Term Storage: -20°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.

Transportation: Not dangerous goods

Description: IR-820 is a near infrared dye (NIR), which has a broad absorption band at 690nm in aqueous solution, with high resistance to photodegradation and photocleavage. IR-820 is an excellent probe for imaging tumors, as it can be detected in skin cells, chitosan quaternary ammonium, and subcutaneous tumors using fluorescence imaging. IR-820 is an infrared blood pool contrast agent to detect and quantify diseased tissue in live animals. IR-820 has maximal excitation and emission wavelengths of 710 and 820nm, respectively. IR-820 emission is significantly improved in vivo on serum binding to albumin, and elimination occurs predominantly via the gastrointestinal tract. IR820 has optical and thermal generation properties similar to those of indocyanine green (ICG) but with improved in vitro and in vivo stability. The fluorescent emission of IR820 has a lower quantum yield than ICG but less dependence of the emission peak location on concentration. IR820 demonstrated degradation half-times approximately double those of ICG under all temperature and light conditions in aqueous solution. IR-820 is a cost-effective imaging agent with low cytotoxicity. Spectral Data: &lambda
Smiles: ClC1=C(/C=C/C2=[N+](CCCCS(=O)(O[Na])=O)C3=C(C(C=CC=C4)=C4C=C3)C2(C)C)CCC/C1=C\C=C5N(CCCCS(=O)([O-])=O)C(C=CC6=C7C=CC=C6)=C7C/5(C)C
InChi Key: RANIQVAJHXBIAY-UHFFFAOYSA-M
References: [1] P.V.V. Jayaweera & A.G.U. Perera, Appl. Phys. Lett. 85, 5754 (2004) , [2] S.I. Prajapati, et al., Mol. Imaging 8, 45 (2009) , [3] A. Fernandez-Fernandez, et al., Mol. Imaging 11, 99 (2012) , [4] z. Feng, et al., Theranostics 9, 5706 (2019)
InChi: InChI=1S/C46H51ClN2O6S2.Na/c1-45(2)40(48(28-9-11-30-56(50,51)52)38-24-20-32-14-5-7-18-36(32)42(38)45)26-22-34-16-13-17-35(44(34)47)23-27-41-46(3,4)43-37-19-8-6-15-33(37)21-25-39(43)49(41)29-10-12-31-57(53,54)55

IR-820 is a near infrared dye (NIR), which has a broad absorption band at 690nm in aqueous solution, with high resistance to photodegradation and photocleavage. IR-820 is an excellent probe for imaging tumors, as it can be detected in skin cells, chitosan quaternary ammonium, and subcutaneous tumors using fluorescence imaging. IR-820 is an infrared blood pool contrast agent to detect and quantify diseased tissue in live animals. IR-820 has maximal excitation and emission wavelengths of 710 and 820nm, respectively. IR-820 emission is significantly improved in vivo on serum binding to albumin, and elimination occurs predominantly via the gastrointestinal tract. IR820 has optical and thermal generation properties similar to those of indocyanine green (ICG) but with improved in vitro and in vivo stability. The fluorescent emission of IR820 has a lower quantum yield than ICG but less dependence of the emission peak location on concentration. IR820 demonstrated degradation half-times approximately double those of ICG under all temperature and light conditions in aqueous solution. IR-820 is a cost-effective imaging agent with low cytotoxicity. Spectral Data: &lambda

SKU: N0516 Category: Reagents for Life Sciences

Additional information

Additional information

Synonyms	IR820 Dye
Purity	≥98% (HPLC)
Appearance	Green to red-brown powder
CAS-Number	172616-80-7
Molecular Formula	C46H50ClN2NaO6S2
Molecular Weight	849.47
Identity	1H-NMR
Solvents	Soluble in DMSO or methanol.
UV / Vis	817 – 823 nm (c=0.005 g/l methanol)
Smiles	ClC1=C(/C=C/C2=[N+](CCCCS(=O)(O[Na])=O)C3=C(C(C=CC=C4)=C4C=C3)C2(C)C)CCC/C1=C\C=C5N(CCCCS(=O)([O-])=O)C(C=CC6=C7C=CC=C6)=C7C/5(C)C
InChi Key	RANIQVAJHXBIAY-UHFFFAOYSA-M
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Transportation	Not dangerous goods
References	[1] P.V.V. Jayaweera & A.G.U. Perera, Appl. Phys. Lett. 85, 5754 (2004), [2] S.I. Prajapati, et al., Mol. Imaging 8, 45 (2009), [3] A. Fernandez-Fernandez, et al., Mol. Imaging 11, 99 (2012), [4] z. Feng, et al., Theranostics 9, 5706 (2019)
InChi	InChI=1S/C46H51ClN2O6S2.Na/c1-45(2)40(48(28-9-11-30-56(50,51)52)38-24-20-32-14-5-7-18-36(32)42(38)45)26-22-34-16-13-17-35(44(34)47)23-27-41-46(3,4)43-37-19-8-6-15-33(37)21-25-39(43)49(41)29-10-12-31-57(53,54)55
Quantity	1 g, Bulk