Available from stock

Olanzapine

SKU: O0143

Categories:

Synonyms: 2-Methyl-4-(4-methyl-1-piperazinyl)- 10H-thieno[2,3-b][1,5]benzodiazepine , LY-170053; 132539-06-1
CAS-Number: C₁₇H₂₀N₄S
Molecular Formula: 312.43
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: Yellow powder
Identity: 1H-NMR

Properties

Solvents: DMSO (10 mg/ml), DMF

Documentation

Safety Data Sheet (SDS): CDX O0143 MSDS.pdf

Shipping: AMBIENT
Short Term Storage: +4°C
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Hazard statements: H315-H319-H413
Precautionary statements: P305 + P351 + P338
GHS Symbol: GHS07
Signal word: Warning
Transportation: Not dangerous goods

Description: Olanzapine is a 5-HT2 serotonin and D1/D2 dopamine receptor antagonist, that binds to dopamine D1, D2, and D4 receptors (Ki=31, 11, and 27 nM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT2C and 5-HT3 (Ki=4, 11, and 57 nM, respectively). It also binds to M1 muscarinic acetylcholine, α1-adrenergic and histamine H1 receptors (Ki=2, 19, and 7 nM, respectively). Olanzapine is an atypical antipsychotic that displays anticholinergic properties. Olanzapine shows antidepressant-like activity. Formulations containing olanzapine have been used in the treatment of schizophrenia and bipolar disorder and for the prevention and treatment of chronic nausea and chemotherapy-induced nausea and vomiting.
Smiles: CN1CCN(CC1)C1=NC2=CC=CC=C2NC2=C1C=C(C)S2
InChi Key: KVWDHTXUZHCGIO-UHFFFAOYSA-N
References: (1) N.A. Moore, et al., J. Pharmacol. Exp. Ther. 262, 545 (1992) , (2) F.P. Bymaster, et al., Neuropsychopharmacol. 14, 87 (1996) , (3) G.D. Tollefson & C.C. Taylor, CNS Drug Reviews 6, 303 (2000) , (4) E. Nowakowska, et al., Pharmacol. Rep. 66, 404 (2014) , (5) D.M. Ashby, et al., Behav. Pharmacol. 26, 133 (2015) , (6) C. Fonte, et al., Crit. Rev. Oncol. Hematol. 95, 214 (2015)

Olanzapine is a 5-HT2 serotonin and D1/D2 dopamine receptor antagonist, that binds to dopamine D1, D2, and D4 receptors (Ki=31, 11, and 27 nM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT2C and 5-HT3 (Ki=4, 11, and 57 nM, respectively). It also binds to M1 muscarinic acetylcholine, α1-adrenergic and histamine H1 receptors (Ki=2, 19, and 7 nM, respectively). Olanzapine is an atypical antipsychotic that displays anticholinergic properties. Olanzapine shows antidepressant-like activity. Formulations containing olanzapine have been used in the treatment of schizophrenia and bipolar disorder and for the prevention and treatment of chronic nausea and chemotherapy-induced nausea and vomiting.

SKU: O0143

Additional information

Additional information

Synonyms	2-Methyl-4-(4-methyl-1-piperazinyl)- 10H-thieno[2,3-b][1,5]benzodiazepine, LY-170053
Purity	≥98% (HPLC)
Appearance	Yellow powder
CAS-Number	132539-06-1
Molecular Formula	C17H20N4S
Molecular Weight	312.43
Identity	1H-NMR
Solvents	DMSO (10 mg/ml), DMF
Smiles	CN1CCN(CC1)C1=NC2=CC=CC=C2NC2=C1C=C(C)S2
InChi Key	KVWDHTXUZHCGIO-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements	H315-H319-H413
Precautionary statements	P305 + P351 + P338
GHS Symbol	GHS07
Signal word	Warning
Transportation	Not dangerous goods
References	(1) N.A. Moore, et al., J. Pharmacol. Exp. Ther. 262, 545 (1992), (2) F.P. Bymaster, et al., Neuropsychopharmacol. 14, 87 (1996), (3) G.D. Tollefson & C.C. Taylor, CNS Drug Reviews 6, 303 (2000), (4) E. Nowakowska, et al., Pharmacol. Rep. 66, 404 (2014), (5) D.M. Ashby, et al., Behav. Pharmacol. 26, 133 (2015), (6) C. Fonte, et al., Crit. Rev. Oncol. Hematol. 95, 214 (2015)
Quantity	1 g, 5 g, Bulk