Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (10 mg/ml)
Available from stock
Ononin
- SKU
- O0086
Category: Carbohydrates
- Synonyms
- Formononetin 7-O-β.-D-glucopyranoside , Ononoside
- 486-62-4
- CAS-Number
- C22H22O9
- Molecular Formula
- 430.40
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- RT
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at RT.
- Transportation
- Not dangerous goods
- Description
- Ononin is a glycoside isoflavone that has been found in soybeans. It has anti-inflammatory activity by inhibiting the NF-?B and MAPK pathways and neuroprotective properties. Ononin inhibits LPS-induced production of nitrite, prostaglandin E2 and the pro-inflammatory cytokines IL-1β, IL-6, and TNF-α by RAW 264.7 macrophages. It also inhibits glutamate-induced toxicity in rat adrenal PC12 cells.
- Smiles
- O[C@H]1[C@H](OC2=CC=C(C(C(C3=CC=C(OC)C=C3)=CO4)=O)C4=C2)O[C@H](CO)[C@@H](O)[C@@H]1O
- InChi Key
- MGJLSBDCWOSMHL-MIUGBVLSSA-N
- References
- (1) D. Yu, et al., J. Ethnopharmacol. 98, 89 (2005) , (2) L. Dong, et al., Mol. Immunol. 83, 46 (2017) , (3) T. Wang, et al., J. Sci. Food Agric. 98, 2043 (2018) , (4) Y. Yu, et al., Pharmacol. Res. 145, 104248 (2019) , (5) L. Luo, et al., Metabolomics 15, 153 (2019)
- InChi
- InChI=1S/C22H22O9/c1-28-12-4-2-11(3-5-12)15-10-29-16-8-13(6-7-14(16)18(15)24)30-22-21(27)20(26)19(25)17(9-23)31-22/h2-8,10,17,19-23,25-27H,9H2,1H3/t17-,19-,20+,21-,22-/m1/s1
Ononin is a glycoside isoflavone that has been found in soybeans. It has anti-inflammatory activity by inhibiting the NF-?B and MAPK pathways and neuroprotective properties. Ononin inhibits LPS-induced production of nitrite, prostaglandin E2 and the pro-inflammatory cytokines IL-1β, IL-6, and TNF-α by RAW 264.7 macrophages. It also inhibits glutamate-induced toxicity in rat adrenal PC12 cells.
Additional information
| Synonyms | Formononetin 7-O-β.-D-glucopyranoside, Ononoside |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | White powder |
| CAS-Number | 486-62-4 |
| Molecular Formula | C22H22O9 |
| Molecular Weight | 430.40 |
| Identity | 1H-NMR |
| Solvents | DMSO (10 mg/ml) |
| Smiles | O[C@H]1[C@H](OC2=CC=C(C(C(C3=CC=C(OC)C=C3)=CO4)=O)C4=C2)O[C@H](CO)[C@@H](O)[C@@H]1O |
| InChi Key | MGJLSBDCWOSMHL-MIUGBVLSSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | RT |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
| Transportation | Not dangerous goods |
| References | (1) D. Yu, et al., J. Ethnopharmacol. 98, 89 (2005), (2) L. Dong, et al., Mol. Immunol. 83, 46 (2017), (3) T. Wang, et al., J. Sci. Food Agric. 98, 2043 (2018), (4) Y. Yu, et al., Pharmacol. Res. 145, 104248 (2019), (5) L. Luo, et al., Metabolomics 15, 153 (2019) |
| InChi | InChI=1S/C22H22O9/c1-28-12-4-2-11(3-5-12)15-10-29-16-8-13(6-7-14(16)18(15)24)30-22-21(27)20(26)19(25)17(9-23)31-22/h2-8,10,17,19-23,25-27H,9H2,1H3/t17-,19-,20+,21-,22-/m1/s1 |
| Quantity | 1 mg, Bulk |
