Specifications
- Purity
- ≥98% (HPLC)
- Identity
- 1H-NMR
- Appearance
- White to off-white powder
Properties
- Solvents
- DMSO (20 mg/ml), DMF (20 mg/ml), ethanol (20 mg/ml), water (insoluble)
Category: Phytochemicals
Oridonin is a diterpenoid that has been found in R. rubescens and has anti-inflammatory and anticancer, antimicrobial and neuroprotective properties. The regulatory anticancer mechanisms include induction of apoptosis and autophagy, inhibition of proliferation, inhibition of angiogenesis, cell cycle arrest. It is an inhibitor of the TLR4/p38-MAPK and TLR4/NF-?B signaling pathways and PPARγ,. Oridonin is a high affinity inhibitor of NLRP3 inflammasome assembly and activation (Kd = 52.5 nM). It inhibits inflammation in wild-type, but not Nlrp3-/-, mice in a model of high-fat diet-induced type 2 diabetes. Also inhibits glial activation, decreases inflammatory cytokine release, attenuates synaptic loss and improves behavioural deficits in Aβ1-42 treated mice.
Synonyms | 7α,20-Epoxy-1α,6β,7,14-tetrahydroxy-Kaur-16-en-15-one, NSC 250682 |
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Purity | ≥98% (HPLC) |
Appearance | White to off-white powder |
CAS-Number | 28957-04-2 |
Molecular Formula | C20H28O6 |
Molecular Weight | 364.43 |
Identity | 1H-NMR |
Solvents | DMSO (20 mg/ml), DMF (20 mg/ml), ethanol (20 mg/ml), water (insoluble) |
Smiles | O[C@@H]1[C@]2(CO3)[C@@]([C@H](O)[C@]3(O)[C@@](C4=O)([C@@H]5O)[C@@]2([H])CC[C@H]5C4=C)([H])C(C)(C)CC1 |
InChi Key | SDHTXBWLVGWJFT-XKCURVIJSA-N |
Shipping | AMBIENT |
Short Term Storage | RT |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Transportation | Not dangerous goods |
References | (1) T. Ikezoe, et al., Int. J. Oncol. 23, 1187 (2003), (2) J.J. Liu, et al., Ann. Hematol. 83, 691 (2004), (3) T. Ikezoe, et al., Mol. Cancer Ther. 4, 578 (2005), (4) Q. Cui, et al., J. Pharmacol. Sci. 105, 317 (2007), (5) H. Wang, et al., Oncol. Rep. 24, 647 (2010), (6) Z. Liu, et al., Cell Prolif. 45, 499 (2012) (Review), (7) S. Wang, et al., PLoS One 9, e104745 (2014), (8) B.A. Owona & H.J. Schluesener, Drugs R.D. 15, 233 (2015) (Review), (9) S. Wang, et al, PLoS One 11, e0151397 (2016), (10) L. Tian, et al., BMC Complement. Altern. Med. 17, 192 (2017), (11) J. Li, et al., Int. Immunopharmacol. 55, 9 (2018), (12) J. Xu, et al., Molecules 23, E474 (2018) (Review), (13) H. He, et al., Nat. Commun. 9, 2550 (2018), (14) T. Jia, et al., Int. Immunopharmacol. 69, 382 (2019) |
InChi | InChI=1S/C20H28O6/c1-9-10-4-5-11-18-8-26-20(25,19(11,14(9)22)15(10)23)16(24)13(18)17(2,3)7-6-12(18)21/h10-13,15-16,21,23-25H,1,4-8H2,2-3H3/t10-,11-,12-,13+,15+,16-,18+,19-,20+/m0/s1 |
Quantity | 5 mg, 25 mg, Bulk |