Specifications
- Purity
- ≥95% (HPLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO, DMF, ethanol (all 20 mg/ml), methanol (10 mg/ml)
- Melting Point
- 83.5° C
Available from stock
Osthole
- SKU
- O0097
Category: Lipids, Fatty Acids
- Synonyms
- 7-Methoxy-8-(3-methyl-2-butenyl)coumarin , 7-Methoxy-8-isopentenylcoumarin , NSC 31868
- 484-12-8
- CAS-Number
- C15H16O3
- Molecular Formula
- 244.29
- Molecular Weight
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- RT
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at RT.
- Transportation
- Not dangerous goods
- Description
- Osthole is a natural coumarin that was first isolated from several medicinal plants, including C. monnieri and A. pubescens. Osthole exhibits immunomodulatory, antioxidative, and anti-inflammatory properties, by regulating the expression of TNF-α, NF-?B, TGF-β, cyclooxygenases, leukotrienes, nitric oxide, ERK and JNK. Shows also anti-cancer, chemopherapeutic, analgesic, neuroprotective, antipruritic, anti-leishmania and anti-lipedemic activities. It is reported to induce a nonspecific elevation of cAMP and cGMP levels through its ability to inhibit phosphodiesterases, which leads to a modulation of calcium channel signaling and vasorelaxant effects. Selectively inhibits TRPV3 channels in skin. Induces apoptosis and cell cycle arrest in cancer cells. Suppression of fatty acid synthase expression in HER2-overexpressing breast cancer cells indicates osthole as a promising agent for chemotherapy.
- Smiles
- O=C1OC2=C(C/C=C(C)/C)C(OC)=CC=C2C=C1
- InChi Key
- MBRLOUHOWLUMFF-UHFFFAOYSA-N
- References
- (1) R.L. Huang, et al., Hepatology 24, 508 (1996) , (2) L. Wang, et al., J. Biomed. Res. 29, 132 (2015) , (3) Z.R. Zhang, et al., Evid.-Based Complem. Altern. Med. 2015, 919616 (2016) , (4) E.K. Kermani, et al., Pharmacognosy Res. 8, S1 (2016) , (5) X.M. Xu, et al., Oncol. Lett. 12, 3779 (2016) , (6) Y. Che, et al., Oncol. Rep. 40, 737 (2018) , (7) X.Y. Sun, et al., Mol. Pharmacol. 94, 1164 (2018) , (8) Y. Yao, et al., Life Sci. 217, 16 (2019)
Osthole is a natural coumarin that was first isolated from several medicinal plants, including C. monnieri and A. pubescens. Osthole exhibits immunomodulatory, antioxidative, and anti-inflammatory properties, by regulating the expression of TNF-α, NF-?B, TGF-β, cyclooxygenases, leukotrienes, nitric oxide, ERK and JNK. Shows also anti-cancer, chemopherapeutic, analgesic, neuroprotective, antipruritic, anti-leishmania and anti-lipedemic activities. It is reported to induce a nonspecific elevation of cAMP and cGMP levels through its ability to inhibit phosphodiesterases, which leads to a modulation of calcium channel signaling and vasorelaxant effects. Selectively inhibits TRPV3 channels in skin. Induces apoptosis and cell cycle arrest in cancer cells. Suppression of fatty acid synthase expression in HER2-overexpressing breast cancer cells indicates osthole as a promising agent for chemotherapy.
Additional information
| Synonyms | 7-Methoxy-8-(3-methyl-2-butenyl)coumarin, 7-Methoxy-8-isopentenylcoumarin, NSC 31868 |
|---|---|
| Purity | ≥95% (HPLC) |
| Appearance | White to off-white powder |
| CAS-Number | 484-12-8 |
| Molecular Formula | C15H16O3 |
| Molecular Weight | 244.29 |
| Identity | 1H-NMR |
| Solvents | DMSO, DMF, ethanol (all 20 mg/ml), methanol (10 mg/ml) |
| Melting Point | 83.5° C |
| Smiles | O=C1OC2=C(C/C=C(C)/C)C(OC)=CC=C2C=C1 |
| InChi Key | MBRLOUHOWLUMFF-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | RT |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
| Transportation | Not dangerous goods |
| References | (1) R.L. Huang, et al., Hepatology 24, 508 (1996), (2) L. Wang, et al., J. Biomed. Res. 29, 132 (2015), (3) Z.R. Zhang, et al., Evid.-Based Complem. Altern. Med. 2015, 919616 (2016), (4) E.K. Kermani, et al., Pharmacognosy Res. 8, S1 (2016), (5) X.M. Xu, et al., Oncol. Lett. 12, 3779 (2016), (6) Y. Che, et al., Oncol. Rep. 40, 737 (2018), (7) X.Y. Sun, et al., Mol. Pharmacol. 94, 1164 (2018), (8) Y. Yao, et al., Life Sci. 217, 16 (2019) |
| Quantity | 10 mg, 50 mg, Bulk |
