Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- ethanol (25 mg/ml), methanol, DMSO, DMF or water (all 10 mg/ml)
Category: Phytochemicals
Oxymatrine is a natural alkaloid from plants used in traditional Chinese herbal medicine. It has antiviral properties, inhibiting the replication of hepatitis B (HBV) through heat-stress cognate 70 (Hsc70) downregulation. Oxymatrine also prevents fibrosis in a number of organs including liver, at least in part by interfering with TGF-β signaling. This compound also induces apoptosis in certain cancer cells and ameliorates inflammation by impairing the translocation of NF-?B. Neuroprotective by inhibition of apoptosis in neurons.
Synonyms | Matrine 1-oxide, Matrine N-oxide, Ammothamnine |
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Purity | ≥98% (HPLC) |
Appearance | White to off-white powder |
CAS-Number | 16837-52-8 |
Molecular Formula | C15H24N2O2 |
Molecular Weight | 264.36 |
Identity | 1H-NMR |
Solvents | ethanol (25 mg/ml), methanol, DMSO, DMF or water (all 10 mg/ml) |
Smiles | [O-][N+]12CCC[C@]3([H])[C@@]1([H])[C@]([C@](CCCC4=O)([H])N4C3)([H])CCC2 |
InChi Key | XVPBINOPNYFXID-LHDUFFHYSA-N |
Shipping | AMBIENT |
Short Term Storage | RT |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Hazard statements | H302 |
Precautionary statements | P264+P270+P301+P312+P330+P501 |
GHS Symbol | GHS07 |
Signal word | Warning |
Transportation | Not dangerous goods |
References | (1) X.L. Wu, et al., World J. Gastroenterol. 14, 2100 (2008), (2) J.W. Ngan, et al., Anticancer Agents Med. Chem. 9, 823 (2009) (Review), (3) X. Cui, et al., Biosci. Trends 4, 39 (2010), (4) X.Q. Dong, et al., Inflamm. Res. 60, 533 (2010), (5) Q. Ling, et al., J. Exp. Clin. Cancer Res. 30, 66 (2011), (6) X.C. Shen, et al., J. Asian Nat. Prod. Res. 13, 215 (2011), (7) N.L. Chai, et al., World J. Gastroenterol. 18, 4199 (2012), (8) J.R. Guzman, et al., Sci. Rep. 3, 1629 (2013), (9) C.E. Halim, et al., Pharmacol. Res. 147, 104327 (2019) (Review) |
Quantity | 100 mg, 500 mg, Bulk |