Available from stock

Oxymatrine

SKU: O0077

Category: Phytochemicals

Synonyms: Matrine 1-oxide , Matrine N-oxide , Ammothamnine; 16837-52-8
CAS-Number: C₁₅H₂₄N₂O₂
Molecular Formula: 264.36
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: White to off-white powder
Identity: 1H-NMR

Properties

Solvents: ethanol (25 mg/ml), methanol, DMSO, DMF or water (all 10 mg/ml)

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Hazard statements: H302
Precautionary statements: P264+P270+P301+P312+P330+P501
GHS Symbol: GHS07
Signal word: Warning
Transportation: Not dangerous goods

Description: Oxymatrine is a natural alkaloid from plants used in traditional Chinese herbal medicine. It has antiviral properties, inhibiting the replication of hepatitis B (HBV) through heat-stress cognate 70 (Hsc70) downregulation. Oxymatrine also prevents fibrosis in a number of organs including liver, at least in part by interfering with TGF-β signaling. This compound also induces apoptosis in certain cancer cells and ameliorates inflammation by impairing the translocation of NF-?B. Neuroprotective by inhibition of apoptosis in neurons.
Smiles: [O-][N+]12CCC[C@]3([H])[C@@]1([H])[C@]([C@](CCCC4=O)([H])N4C3)([H])CCC2
InChi Key: XVPBINOPNYFXID-LHDUFFHYSA-N
References: (1) X.L. Wu, et al., World J. Gastroenterol. 14, 2100 (2008) , (2) J.W. Ngan, et al., Anticancer Agents Med. Chem. 9, 823 (2009) (Review) , (3) X. Cui, et al., Biosci. Trends 4, 39 (2010) , (4) X.Q. Dong, et al., Inflamm. Res. 60, 533 (2010) , (5) Q. Ling, et al., J. Exp. Clin. Cancer Res. 30, 66 (2011) , (6) X.C. Shen, et al., J. Asian Nat. Prod. Res. 13, 215 (2011) , (7) N.L. Chai, et al., World J. Gastroenterol. 18, 4199 (2012) , (8) J.R. Guzman, et al., Sci. Rep. 3, 1629 (2013) , (9) C.E. Halim, et al., Pharmacol. Res. 147, 104327 (2019) (Review)

Oxymatrine is a natural alkaloid from plants used in traditional Chinese herbal medicine. It has antiviral properties, inhibiting the replication of hepatitis B (HBV) through heat-stress cognate 70 (Hsc70) downregulation. Oxymatrine also prevents fibrosis in a number of organs including liver, at least in part by interfering with TGF-β signaling. This compound also induces apoptosis in certain cancer cells and ameliorates inflammation by impairing the translocation of NF-?B. Neuroprotective by inhibition of apoptosis in neurons.

SKU: O0077 Category: Phytochemicals

Additional information

Additional information

Synonyms	Matrine 1-oxide, Matrine N-oxide, Ammothamnine
Purity	≥98% (HPLC)
Appearance	White to off-white powder
CAS-Number	16837-52-8
Molecular Formula	C15H24N2O2
Molecular Weight	264.36
Identity	1H-NMR
Solvents	ethanol (25 mg/ml), methanol, DMSO, DMF or water (all 10 mg/ml)
Smiles	[O-][N+]12CCC[C@]3([H])[C@@]1([H])[C@]([C@](CCCC4=O)([H])N4C3)([H])CCC2
InChi Key	XVPBINOPNYFXID-LHDUFFHYSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements	H302
Precautionary statements	P264+P270+P301+P312+P330+P501
GHS Symbol	GHS07
Signal word	Warning
Transportation	Not dangerous goods
References	(1) X.L. Wu, et al., World J. Gastroenterol. 14, 2100 (2008), (2) J.W. Ngan, et al., Anticancer Agents Med. Chem. 9, 823 (2009) (Review), (3) X. Cui, et al., Biosci. Trends 4, 39 (2010), (4) X.Q. Dong, et al., Inflamm. Res. 60, 533 (2010), (5) Q. Ling, et al., J. Exp. Clin. Cancer Res. 30, 66 (2011), (6) X.C. Shen, et al., J. Asian Nat. Prod. Res. 13, 215 (2011), (7) N.L. Chai, et al., World J. Gastroenterol. 18, 4199 (2012), (8) J.R. Guzman, et al., Sci. Rep. 3, 1629 (2013), (9) C.E. Halim, et al., Pharmacol. Res. 147, 104327 (2019) (Review)
Quantity	100 mg, 500 mg, Bulk