Paclitaxel

SKU: P0188

Category: Antibiotics

Synonyms: Taxol , BMS 181339-01 , NSC 125973; 33069-62-4
CAS-Number: C₄₇H₅₁NO₁₄
Molecular Formula: 853.91
Molecular Weight

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98%
Identity: IR
Appearance: White to off-white powder

Properties

Solvents: DMSO (50 mg/ml), methanol (50 mg/ml), ethanol

Downloads

Safety Data Sheet: CDX P0188 MSDS.pdf

Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.
Long Term Storage: +4°C
Short Term Storage: +4°C
Shipping: AMBIENT

Transportation: Not dangerous goods
Signal word: Danger
GHS Symbol: GHS08
Precautionary statements: P201-P260-P280-P308 + P313
Hazard statements: H341-H360-H371-H413

Description: Anticancer compound. Chemotherapeutic used in patients with cancer and advanced forms of Kaposi's sarcoma. Microtubule assembly stabilizer. Reversibly binds to polymerized tubulin. Mitotic spindle assembly, chromosome segregation and cell division inhibitor. Induces cell cycle arrest at the G2/M phase. Apoptosis inducer through aberrant activation of cyclin-dependent kinases (CKDs) and the c-Jun N-terminal kinase/stress activated protein kinase (JNK/SAPK). Immunosuppressor, immunostimulant and TRAIL sensitizer.
InChi: InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1
References: (1) J.E. Liebmann, et al., Br. J. Cancer 68, 1104 (1993) , (2) R. Foa, et al., Int. J. Clin. Lab. Res. 24, 6 (1994) (Review) , (3) M. Woods, et al., Mol. Med. 1, 506 (1995) , (4) A. Jordan, et al., Med. Res. Rev. 18, 259 (1998) , (5) L.A. Amos & J. Löwe, Chem. Biol. 6, R65 (1999) (Review) , (6) M.V. Blagosklonny & T. Fojo, Int. J. Cancer 83, 151 (1999) , (7) T.H. Wang, et al., J. Biol. Chem. 274, 8208 (1999) , (8) T.H. Wang, et al., Cancer 88, 2619 (2000) , (9) T.M. Mekhail & M. Markman, Expert Opin. Pharmacother. 3, 755 (2002) , (10) A. Javeed, et al., Eur. J. Pharm. Sci. 38, 283 (2009) (Review) , (11) D. Finlay, et al.,PLoS One 5, e13375 (2010) , (12) B. Ai, et al., Am. J. Cancer Res. 6, 1624 (2016) (Review)
InChi Key: RCINICONZNJXQF-MZXODVADSA-N
Smiles: O[C@](C(C)(C)C1=C(C)[C@H]2OC([C@@H]([C@H](C3=CC=CC=C3)NC(C4=CC=CC=C4)=O)O)=O)(C2)[C@H]([C@]([C@]([C@@H](O)C5)(C)C([C@@H]1OC(C)=O)=O)([H])[C@]6([C@]5([H])OC6)OC(C)=O)OC(C7=CC=CC=C7)=O

Anticancer compound. Chemotherapeutic used in patients with cancer and advanced forms of Kaposi’s sarcoma. Microtubule assembly stabilizer. Reversibly binds to polymerized tubulin. Mitotic spindle assembly, chromosome segregation and cell division inhibitor. Induces cell cycle arrest at the G2/M phase. Apoptosis inducer through aberrant activation of cyclin-dependent kinases (CKDs) and the c-Jun N-terminal kinase/stress activated protein kinase (JNK/SAPK). Immunosuppressor, immunostimulant and TRAIL sensitizer.

SKU: P0188 Category: Antibiotics

Additional information

Additional information

Synonyms	Taxol, BMS 181339-01, NSC 125973
Purity	≥98%
Appearance	White to off-white powder
CAS-Number	33069-62-4
Molecular Formula	C47H51NO14
Molecular Weight	853.91
Identity	IR
Solvents	DMSO (50 mg/ml), methanol (50 mg/ml), ethanol
Smiles	O[C@](C(C)(C)C1=C(C)[C@H]2OC([C@@H]([C@H](C3=CC=CC=C3)NC(C4=CC=CC=C4)=O)O)=O)(C2)[C@H]([C@]([C@]([C@@H](O)C5)(C)C([C@@H]1OC(C)=O)=O)([H])[C@]6([C@]5([H])OC6)OC(C)=O)OC(C7=CC=CC=C7)=O
InChi Key	RCINICONZNJXQF-MZXODVADSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements	H341-H360-H371-H413
Precautionary statements	P201-P260-P280-P308 + P313
GHS Symbol	GHS08
Signal word	Danger
Transportation	Not dangerous goods
References	(1) J.E. Liebmann, et al., Br. J. Cancer 68, 1104 (1993), (2) R. Foa, et al., Int. J. Clin. Lab. Res. 24, 6 (1994) (Review), (3) M. Woods, et al., Mol. Med. 1, 506 (1995), (4) A. Jordan, et al., Med. Res. Rev. 18, 259 (1998), (5) L.A. Amos & J. Löwe, Chem. Biol. 6, R65 (1999) (Review), (6) M.V. Blagosklonny & T. Fojo, Int. J. Cancer 83, 151 (1999), (7) T.H. Wang, et al., J. Biol. Chem. 274, 8208 (1999), (8) T.H. Wang, et al., Cancer 88, 2619 (2000), (9) T.M. Mekhail & M. Markman, Expert Opin. Pharmacother. 3, 755 (2002), (10) A. Javeed, et al., Eur. J. Pharm. Sci. 38, 283 (2009) (Review), (11) D. Finlay, et al.,PLoS One 5, e13375 (2010), (12) B. Ai, et al., Am. J. Cancer Res. 6, 1624 (2016) (Review)
InChi	InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1
Quantity	10 mg, 50 mg, Bulk