Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO, ethanol, chloroform
- Melting Point
- 115-116 °C (lit.)
Category: Lipids, Fatty Acids
Anticancer and antiangiogenic compound. Induces apoptosis, cell cycle arrest and autophagy in various cancer cell lines. At low concentrations acts as antioxidant reducing oxidative stress generated through the TCR signaling pathway. At high concentration induces O2- and causes oxidative-stress-mediated apoptosis. Potent anti-inflammatory and anti-atherosclerotic agent. NF-kB inhibitor by directly targeting IkB kinase. NLRP3 inflammasome inhibitor. Inhibits ATPase activity of NLRP3 and protease activity of caspase 1. Specifically inhibits HDAC1 without affecting other class I/II HDACs. DNA methyltransferase 1 (DNMT1) inhibitor. Reduces the expression of VEGF and its receptors VEGRF1 and 2. Microtubule-interfering compound, inhibiting cell migration and tubule formation. Anti-leishmanial and anti-trypanosomal agent.
Purity | ≥98% (HPLC) |
---|---|
Appearance | White to off-white powder |
CAS-Number | 20554-84-1 |
Molecular Formula | C15H20O3 |
Molecular Weight | 248.32 |
Identity | 1H-NMR |
Solvents | DMSO, ethanol, chloroform |
Melting Point | 115-116 °C (lit.) |
Smiles | C/C1=CCC[C@](O2)(C)[C@H]2[C@@H](OC(C3=C)=O)[C@H]3CC1 |
InChi Key | KTEXNACQROZXEV-PVLRGYAZSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Transportation | Not dangerous goods |
References | (1) R.M. Wiedhopf, et al., J. Pharm. Sci. 62, 345 (1973), (2) B.H. Kwok, et al., Chem. Biol. 8, 759 (2001), (3) P. Pozarowski, et al., Cell Cycle 2, 377 (2003), (4) T.S. Tiuman, et al., Antimicrob. Agents Chemother. 49, 176 (2005), (5) M. Li-Weber, et al., Cell Death Differ. 12, 408 (2005), (6) Y.N. Gopal, et al., Chem. Biol. 14, 813 (2007), (7) E. Izumi, et al., Exp. Parasitol. 118, 324 (2008), (8) Z. Liu, et al., J. Pharmacol. Exp. Ther. 329, 505 (2009), (9) C. Juliana, et al., J. Biol. Chem. 285, 9792 (2010), (10) L. Zhao, et al., Nutr. Rev. 69, 310 (2011) (Review), (11) V.B. Mathema, et al., Inflammation 35, 560 (2012) (Review), (12) S.L. Kim, et al., Int. J. Mol. Med. 33, 1261 (2014) |
InChi | InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1 |
Quantity | 25 mg, Bulk |