Specifications
- Purity
- ≥95% (NMR)
- Appearance
- Solution
- Identity
- 1H-NMR
- Concentration
- 100 ug/ml in acetonitrile
Properties
- Solvents
- Soluble in acetonitrile and buffer.
Available from stock
Propiconazole solution, 100 ug/ml in acetonitrile
- SKU
- P0414
Category: Fungicides
- Synonyms
- PPZ, CGA 64250, CGD 92710F, Proconazole, Microban S 2140
- 60207-90-1
- CAS-Number
- C15H17Cl2N3O2
- Molecular Formula
- 342.22
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- +4°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at +4°C.
- Hazard statements
- H225,H301 + H311 + H331,H370
- Precautionary statements
- P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
- GHS Symbol
- GHS02+GHS06+GHS08
- Signal word
- Danger
- RIDADR
- UN1230
- Transportation
- Packing Group II
- Description
- Propiconazole is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via the demethylation of C-14, leading to fungal cell membrane disruption. Formulations containing propiconazole have been used in the control of fungi in agriculture. It inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450. Propiconazole inhibits the growth of T. deformans and R. stolonifer, as well as A. niger, M. fructigena, S. nodorum, T. harzanium, R. solani, and S. rolfsii at concentrations ranging from 0.1 to 5 ppm. This compound can be used as analytical reference material. Propiconazole increases production of reactive oxygen species (ROS), the number of DNA mutations, and the incidence of tumor formation in mouse liver. Shown to activate PXR and disrupt hepatic metabolism in mice.
- Smiles
- ClC1=CC(Cl)=CC=C1C2(CN3N=CN=C3)OC(CCC)CO2
- InChi Key
- STJLVHWMYQXCPB-UHFFFAOYSA-N
- References
- (1) H. Vanden Bossche, te al.; Pestic. Sci. 15, 188 (1984) , (2) M. Sancholle, et al.; Pest. Biochem. Phys. 21, 31 (1984) , (3) J.A. Zarn, et al.; Environ. Health Perspect. 111, 255 (2003) , (4) M. Calonne, et al.; Chemosphere 87, 376 (2012) , (5) C.S. Mazur, et al., Toxicol. Lett. 232, 37 (2015) , (6) N.O. Costa, et al.; Toxicology 335, 55 (2015) , (7) J. Valades, et al.; Environ. Sci. Pollut. Res. Int. 26, 27808 (2019) , (8) B. Attema, et al; Arch. Toxicol. (Epub ahead of print) (2024)
- InChi
- InChI=1S/C15H17Cl2N3O2/c1-2-3-12-7-21-15(22-12,8-20-10-18-9-19-20)13-5-4-11(16)6-14(13)17/h4-6,9-10,12H,2-3,7-8H2,1H3
Propiconazole is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via the demethylation of C-14, leading to fungal cell membrane disruption. Formulations containing propiconazole have been used in the control of fungi in agriculture. It inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450. Propiconazole inhibits the growth of T. deformans and R. stolonifer, as well as A. niger, M. fructigena, S. nodorum, T. harzanium, R. solani, and S. rolfsii at concentrations ranging from 0.1 to 5 ppm. This compound can be used as analytical reference material. Propiconazole increases production of reactive oxygen species (ROS), the number of DNA mutations, and the incidence of tumor formation in mouse liver. Shown to activate PXR and disrupt hepatic metabolism in mice.
Additional information
| Synonyms | PPZ, CGA 64250, CGD 92710F, Proconazole, Microban S 2140 |
|---|---|
| Purity | ≥95% (NMR) |
| Appearance | Solution |
| CAS-Number | 60207-90-1 |
| Molecular Formula | C15H17Cl2N3O2 |
| Molecular Weight | 342.22 |
| Identity | 1H-NMR |
| Solvents | Soluble in acetonitrile and buffer. |
| Smiles | ClC1=CC(Cl)=CC=C1C2(CN3N=CN=C3)OC(CCC)CO2 |
| InChi Key | STJLVHWMYQXCPB-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Hazard statements | H225,H301 + H311 + H331,H370 |
| Precautionary statements | P210 – P233 – P280 – P301 + P310 – P303 + P361 + P353 – P304 + P340 + P311 |
| GHS Symbol | GHS02+GHS06+GHS08 |
| Signal word | Danger |
| RIDADR | UN1230 |
| Transportation | Packing Group II |
| References | (1) H. Vanden Bossche, te al.; Pestic. Sci. 15, 188 (1984), (2) M. Sancholle, et al.; Pest. Biochem. Phys. 21, 31 (1984), (3) J.A. Zarn, et al.; Environ. Health Perspect. 111, 255 (2003), (4) M. Calonne, et al.; Chemosphere 87, 376 (2012), (5) C.S. Mazur, et al., Toxicol. Lett. 232, 37 (2015), (6) N.O. Costa, et al.; Toxicology 335, 55 (2015), (7) J. Valades, et al.; Environ. Sci. Pollut. Res. Int. 26, 27808 (2019), (8) B. Attema, et al; Arch. Toxicol. (Epub ahead of print) (2024) |
| InChi | InChI=1S/C15H17Cl2N3O2/c1-2-3-12-7-21-15(22-12,8-20-10-18-9-19-20)13-5-4-11(16)6-14(13)17/h4-6,9-10,12H,2-3,7-8H2,1H3 |
| Quantity | 5 ml, Bulk |
| cdx-Concentration | 100 ug/ml in acetonitrile |
