Available from stock

Propiconazole

SKU: P0413

Category: Fungicides

Synonyms: PPZ, CGA 64250, CGD 92710F, Proconazole, Microban S 2140; 60207-90-1
CAS-Number: C₁₅H₁₇Cl₂N₃O₂
Molecular Formula: 342.22
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥95% (NMR)
Appearance: Yellow to light brown semi-solid
Identity: 1H-NMR

Properties

Solvents: Soluble in DMSO (20mg/ml), DMF, ethanol or acentonitrile.
Refractive Index: 1.5440 - 1.5480

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Hazard statements: H302 - H317 - H360FD - H410
Precautionary statements: P202 - P273 - P280 - P301 + P312 - P302 + P352 - P308 + P313
GHS Symbol: GHS07+GHS08+GHS09
Signal word: Danger
RIDADR: UN3082
Transportation: Packing Group III

Description: Propiconazole is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via the demethylation of C-14, leading to fungal cell membrane disruption. Formulations containing propiconazole have been used in the control of fungi in agriculture. It inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450. Propiconazole inhibits the growth of T. deformans and R. stolonifer, as well as A. niger, M. fructigena, S. nodorum, T. harzanium, R. solani, and S. rolfsii at concentrations ranging from 0.1 to 5 ppm. This compound can be used as analytical reference material. Propiconazole increases production of reactive oxygen species (ROS), the number of DNA mutations, and the incidence of tumor formation in mouse liver. Shown to activate PXR and disrupt hepatic metabolism in mice.
Smiles: ClC1=CC(Cl)=CC=C1C2(CN3N=CN=C3)OC(CCC)CO2
InChi Key: STJLVHWMYQXCPB-UHFFFAOYSA-N
References: (1) H. Vanden Bossche, te al.; Pestic. Sci. 15, 188 (1984) , (2) M. Sancholle, et al.; Pest. Biochem. Phys. 21, 31 (1984) , (3) J.A. Zarn, et al.; Environ. Health Perspect. 111, 255 (2003) , (4) M. Calonne, et al.; Chemosphere 87, 376 (2012) , (5) C.S. Mazur, et al., Toxicol. Lett. 232, 37 (2015) , (6) N.O. Costa, et al.; Toxicology 335, 55 (2015) , (7) J. Valades, et al.; Environ. Sci. Pollut. Res. Int. 26, 27808 (2019) , (8) B. Attema, et al; Arch. Toxicol. (Epub ahead of print) (2024)
InChi: InChI=1S/C15H17Cl2N3O2/c1-2-3-12-7-21-15(22-12,8-20-10-18-9-19-20)13-5-4-11(16)6-14(13)17/h4-6,9-10,12H,2-3,7-8H2,1H3

Propiconazole is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via the demethylation of C-14, leading to fungal cell membrane disruption. Formulations containing propiconazole have been used in the control of fungi in agriculture. It inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450. Propiconazole inhibits the growth of T. deformans and R. stolonifer, as well as A. niger, M. fructigena, S. nodorum, T. harzanium, R. solani, and S. rolfsii at concentrations ranging from 0.1 to 5 ppm. This compound can be used as analytical reference material. Propiconazole increases production of reactive oxygen species (ROS), the number of DNA mutations, and the incidence of tumor formation in mouse liver. Shown to activate PXR and disrupt hepatic metabolism in mice.

SKU: P0413 Category: Fungicides

Additional information

Additional information

Synonyms	PPZ, CGA 64250, CGD 92710F, Proconazole, Microban S 2140
Purity	≥95% (NMR)
Appearance	Yellow to light brown semi-solid
CAS-Number	60207-90-1
Molecular Formula	C15H17Cl2N3O2
Molecular Weight	342.22
Identity	1H-NMR
Solvents	Soluble in DMSO (20mg/ml), DMF, ethanol or acentonitrile.
Refractive Index	1.5440 – 1.5480
Smiles	ClC1=CC(Cl)=CC=C1C2(CN3N=CN=C3)OC(CCC)CO2
InChi Key	STJLVHWMYQXCPB-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements	H302 – H317 – H360FD – H410
Precautionary statements	P202 – P273 – P280 – P301 + P312 – P302 + P352 – P308 + P313
GHS Symbol	GHS07+GHS08+GHS09
Signal word	Danger
RIDADR	UN3082
Transportation	Packing Group III
References	(1) H. Vanden Bossche, te al.; Pestic. Sci. 15, 188 (1984), (2) M. Sancholle, et al.; Pest. Biochem. Phys. 21, 31 (1984), (3) J.A. Zarn, et al.; Environ. Health Perspect. 111, 255 (2003), (4) M. Calonne, et al.; Chemosphere 87, 376 (2012), (5) C.S. Mazur, et al., Toxicol. Lett. 232, 37 (2015), (6) N.O. Costa, et al.; Toxicology 335, 55 (2015), (7) J. Valades, et al.; Environ. Sci. Pollut. Res. Int. 26, 27808 (2019), (8) B. Attema, et al; Arch. Toxicol. (Epub ahead of print) (2024)
InChi	InChI=1S/C15H17Cl2N3O2/c1-2-3-12-7-21-15(22-12,8-20-10-18-9-19-20)13-5-4-11(16)6-14(13)17/h4-6,9-10,12H,2-3,7-8H2,1H3
Quantity	250 mg, Bulk