Available from stock

Prostaglandin F2α tromethamine salt

SKU: P0320

Category: Lipids, Fatty Acids

Synonyms: Dinoprost trometamol, PGF2&alpha, tromethamine, Prostaglandin F2&alpha, THAM salt, Prostaglandin F2&alpha, tris salt, Lutalyse, U 14583E, NSC 196515, Minprostin F2&alpha,, Enzaprost T; 38562-01-5
CAS-Number: C₂₀H₃₄O₅ · C₄H₁₁NO₃
Molecular Formula: 475.62
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥99% (TLC)
Appearance: White to off-white powder
Identity: 1H-NMR

Properties

Solvents: Soluble in DMSO, ethanol or methanol (all 50 mg/ml).

Shipping: AMBIENT
Short Term Storage: -20°C
Long Term Storage: -20°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.

Hazard statements: H302-H360
Precautionary statements: P201-P308 + P313
GHS Symbol: GHS07+GHS08
Signal word: Danger
Transportation: Not dangerous goods

Description: Prostaglandin F2&alpha, (PGF2&alpha,) is a widely distributed prostaglandin occurring in many species. It causes contraction of vascular, bronchial, intestinal, and myometrial smooth muscle, and also exhibits potent luteolytic activity. Mechanistically, it acts via activation of the FP (prostaglandin F2&alpha,) receptor to raise intracellular calcium, driving smooth muscle contraction and facilitating luteolysis. This makes it a versatile agent both for controlled reproductive interventions and as a key tool in physiological and pharmacological research. PGF2&alpha, exhibits its receptor mediated physiological activity at 50-100nM.
Smiles: OC(CCC/C=C\C[C@@H]1[C@H]([C@@H](C[C@@H]1O)O)/C=C/[C@@H](O)CCCCC)=O.OCC(CO)(N)CO
InChi Key: IYGXEHDCSOYNKY-RZHHZEQLSA-N
References: (1) L. Speroff & P.W. Ramwell, Am. J. Obstet. Gynecol. 107, 1111 (1970) , (2) B. Samuelsson, et al., Annu. Rev. Biochem. 47, 997 (1978) , (3) K. Watanabe, et al., PNAS 83, 1583 (1986) , (4) D.J. Crankshaw & V. Gaspar, J. Reprod. Fertil. 103, 55 (1995) , (5) C.W. Miller, et al., Endocrinol. 137, 5641 (1996) , (6) F.J. Diaz, et al., Mol. Cell Endocrinol. 191, 65 (2002) , (7) S. Basu, Med. Res. Rev. 27, 435 (2007) , (8) D. Agas, et al., J. Cell Physiol. 228, 25 (2013) , (9) J. Kim & M. Shim, Biochim. Biophys. Acta 1853, 500 (2015) , (10) E. Goupil, et al., J. Biol. Chem. 290, 3137 (2015)
InChi: InChI=1S/C20H34O5.C4H11NO3/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25,5-4(1-6,2-7)3-8/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25),6-8H,1-3,5H2/b7-4-,13-12+,/t15-,16+,17+,18-,19+,/m0./s1

Prostaglandin F2&alpha, (PGF2&alpha,) is a widely distributed prostaglandin occurring in many species. It causes contraction of vascular, bronchial, intestinal, and myometrial smooth muscle, and also exhibits potent luteolytic activity. Mechanistically, it acts via activation of the FP (prostaglandin F2&alpha,) receptor to raise intracellular calcium, driving smooth muscle contraction and facilitating luteolysis. This makes it a versatile agent both for controlled reproductive interventions and as a key tool in physiological and pharmacological research. PGF2&alpha, exhibits its receptor mediated physiological activity at 50-100nM.

SKU: P0320 Category: Lipids, Fatty Acids

Additional information

Additional information

Synonyms	Dinoprost trometamol, PGF2&alpha, tromethamine, Prostaglandin F2&alpha, THAM salt, Prostaglandin F2&alpha, tris salt, Lutalyse, U 14583E, NSC 196515, Minprostin F2&alpha,, Enzaprost T
Purity	≥99% (TLC)
Appearance	White to off-white powder
CAS-Number	38562-01-5
Molecular Formula	C20H34O5 · C4H11NO3
Molecular Weight	475.62
Identity	1H-NMR
Solvents	Soluble in DMSO, ethanol or methanol (all 50 mg/ml).
Smiles	OC(CCC/C=C\C[C@@H]1[C@H]([C@@H](C[C@@H]1O)O)/C=C/[C@@H](O)CCCCC)=O.OCC(CO)(N)CO
InChi Key	IYGXEHDCSOYNKY-RZHHZEQLSA-N
Shipping	AMBIENT
Short Term Storage	-20°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Hazard statements	H302-H360
Precautionary statements	P201-P308 + P313
GHS Symbol	GHS07+GHS08
Signal word	Danger
Transportation	Not dangerous goods
References	(1) L. Speroff & P.W. Ramwell, Am. J. Obstet. Gynecol. 107, 1111 (1970), (2) B. Samuelsson, et al., Annu. Rev. Biochem. 47, 997 (1978), (3) K. Watanabe, et al., PNAS 83, 1583 (1986), (4) D.J. Crankshaw & V. Gaspar, J. Reprod. Fertil. 103, 55 (1995), (5) C.W. Miller, et al., Endocrinol. 137, 5641 (1996), (6) F.J. Diaz, et al., Mol. Cell Endocrinol. 191, 65 (2002), (7) S. Basu, Med. Res. Rev. 27, 435 (2007), (8) D. Agas, et al., J. Cell Physiol. 228, 25 (2013), (9) J. Kim & M. Shim, Biochim. Biophys. Acta 1853, 500 (2015), (10) E. Goupil, et al., J. Biol. Chem. 290, 3137 (2015)
InChi	InChI=1S/C20H34O5.C4H11NO3/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25,5-4(1-6,2-7)3-8/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25),6-8H,1-3,5H2/b7-4-,13-12+,/t15-,16+,17+,18-,19+,/m0./s1
Quantity	5 mg, 10 mg, 25 mg, Bulk