Available from stock

Psoralen

SKU: P0593

Category: Phytochemicals

Synonyms: Ficusin , Furocoumarin , 6,7-Furanocoumarin , NSC 404562 , 7H-Furo[3,2-g]benzopyran-7-one , Furo[3,2-g]coumarin; 66-97-7
CAS-Number: C₁₁H₆O₃
Molecular Formula: 186.16
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: White to off-white powder
Identity: 1H-NMR

Properties

Solvents: DMSO (20 mg/ml), DMF (20 mg/ml), ethanol (5 mg/ml), ethyl acetate, acetone or water (1mg/ml with warming)
Melting Point: 163-164° C
Fluorescence: ex. 335 nm; em. 460 nm (pH 7.0)

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Hazard statements: H302-H315-H319-H335
Precautionary statements: P261-P305 + P351 + P338
GHS Symbol: GHS07
Signal word: Warning
Transportation: Not dangerous goods

Description: Psoralen is a photoactive probe that has been used to investigate nucleic acid structure and function. It intercalates into DNA and, when activated by ultraviolet radiation, can create covalent interstrand crosslinks, inducing apoptosis. Photosensitizing agent that shows anticancer properties by inducing apoptosis and cell cycle arrest, modulating the Wnt/β-catenin pathway. This compound is also used in molecular biology applications. Because of its high UV absorbance, psoralen has been combined with UVA light (PUVA therapy) for the treatment of skin problems such as psoriasis, eczema, vitiligo, and cutaneous T-cell lymphoma. Spectral fluorescence: ?ex=335nm| ?em=460nm (pH 7.0).
Smiles: O=C1C=CC2=C(C=C(OC=C3)C3=C2)O1
InChi Key: ZCCUUQDIBDJBTK-UHFFFAOYSA-N
References: (1) K.M. Vasquez, Environ. Mol. Mutagen 51, 527 (2010) , (2) A. Litovchick, et al., Artif.DNA PNA XNA 5, (2014) , (3) X. Wang, et al., Biol. Pharm. Bull. 39, 815 (2016) , (4) M. Oldham, et al., PLoS One 11, e0162078 (2016) , (5) F. Kouzine, et al., Methods Mol. Biol. 1703, 95 (2018) , (6) X. Wang, et al., Sci. Rep. 8, 14001 (2018) , (7) J. Guitart, JAMA Dermatol. 155, 529 (2019) , (8) X. Wang, et al., Biol. Res. 52, 34 (2019)

Psoralen is a photoactive probe that has been used to investigate nucleic acid structure and function. It intercalates into DNA and, when activated by ultraviolet radiation, can create covalent interstrand crosslinks, inducing apoptosis. Photosensitizing agent that shows anticancer properties by inducing apoptosis and cell cycle arrest, modulating the Wnt/β-catenin pathway. This compound is also used in molecular biology applications. Because of its high UV absorbance, psoralen has been combined with UVA light (PUVA therapy) for the treatment of skin problems such as psoriasis, eczema, vitiligo, and cutaneous T-cell lymphoma. Spectral fluorescence: ?ex=335nm| ?em=460nm (pH 7.0).

SKU: P0593 Category: Phytochemicals

Additional information

Additional information

Synonyms	Ficusin, Furocoumarin, 6,7-Furanocoumarin, NSC 404562, 7H-Furo[3,2-g]benzopyran-7-one, Furo[3,2-g]coumarin
Purity	≥98% (HPLC)
Appearance	White to off-white powder
CAS-Number	66-97-7
Molecular Formula	C11H6O3
Molecular Weight	186.16
Identity	1H-NMR
Solvents	DMSO (20 mg/ml), DMF (20 mg/ml), ethanol (5 mg/ml), ethyl acetate, acetone or water (1mg/ml with warming)
Melting Point	163-164° C
Fluorescence	ex. 335 nm; em. 460 nm (pH 7.0)
Smiles	O=C1C=CC2=C(C=C(OC=C3)C3=C2)O1
InChi Key	ZCCUUQDIBDJBTK-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305 + P351 + P338
GHS Symbol	GHS07
Signal word	Warning
Transportation	Not dangerous goods
References	(1) K.M. Vasquez, Environ. Mol. Mutagen 51, 527 (2010), (2) A. Litovchick, et al., Artif.DNA PNA XNA 5, (2014), (3) X. Wang, et al., Biol. Pharm. Bull. 39, 815 (2016), (4) M. Oldham, et al., PLoS One 11, e0162078 (2016), (5) F. Kouzine, et al., Methods Mol. Biol. 1703, 95 (2018), (6) X. Wang, et al., Sci. Rep. 8, 14001 (2018), (7) J. Guitart, JAMA Dermatol. 155, 529 (2019), (8) X. Wang, et al., Biol. Res. 52, 34 (2019)
Quantity	10 mg, 25 mg, 100 mg, Bulk