Available from stock

Pterostilbene

SKU: P0234

Category: Phytochemicals

Synonyms: trans-3,5-Dimethoxy-4'-Hydroxystilbene , 4-[(1E)-2-(3,5-Dimethoxyphenyl)ethenyl]phenol , 3',5'-Dimethoxy-4-Stilbenol; 537-42-8
CAS-Number: C₁₆H₁₆O₃
Molecular Formula: 256.30
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥97% (HPLC)
Appearance: Off-white to yellow powder
Identity: 1H-NMR

Properties

Solvents: DMSO (20 mg/ml), methanol (10 mg/ml), DMF (30 mg/ml), ethanol (30 mg/ml), water (insoluble)
Melting Point: 89-92 °C

Shipping: AMBIENT
Short Term Storage: +4°C
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Hazard statements: H318-H411
Precautionary statements: P273-P280-P305 + P351 + P338
GHS Symbol: GHS05+GHS09
Signal word: Danger
RIDADR: UN 3077 9
Transportation: Packing Group III

Description: Cell permeable natural methoxylated analog of resveratrol. Antioxidant, antiproliferative, anti-inflammatory, anti-hyperglycemic and anti-diabetic agent. Induces apoptosis. Induces Autophagy. Pterostilbene is a naturally-occurring dimethyl ether analog of resveratrol that is abundant in blueberries. Like resveratrol, pterostilbene acts as a powerful antioxidant, suppresses the synthesis of prostaglandin E2 from lipopolysaccharide-stimulated human peripheral blood mononuclear cells (IC50 = 1.0 ?M for pterostilbene, 3.2 ?M for resveratrol), and inhibits cell proliferation (IC50 = ~60 ?M for both compounds). Very potent inhibitor of cytochrome P450 1A1 (CYP1A1) with Ki=0.57µM. Pterostilbene blocks the activation of ERK1/2, p38 MAPK, and PI3K/Akt signaling pathways, reducing NF-?B and AP-1 transcriptional activation. Moderately inhibits COX-1 and COX-2 (IC50=19.8µM and 83.9µM).
Smiles: OC(C=C1)=CC=C1/C=C/C2=CC(OC)=CC(OC)=C2
InChi Key: VLEUZFDZJKSGMX-ONEGZZNKSA-N
References: (1) M. Manickam, et al., J. Nat. Prod. 60, 609 (1997) , (2) A.M. Rimando, et al., J. Agric. Food Chem. 50, 3453 (2002) , (3) M. Roberti, et al., J. Med. Chem. 46, 3546 (2003) , (4) R. Amorati, et al., J. Org. Chem. 69, 7101 (2004) , (5) S. Hougee, et al., Planta Med. 71, 387 (2005) , (6) P. Ferrer, et al., Neoplasia 7, 37 (2005) , (7) A.M. Rimando, et al., J. Agric. Food Chem. 53, 3403 (2005) , (8) R. Mikstacka, et al., Xenobiotica 36, 269 (2006) , (9) K.A. Roupe, et al., Curr. Clin. Pharmacol. 1, 81 (2006) , (10) R. Mikstacka, et al., Mol. Nutr. Food Res. 51, 517 (2007) , (11) M.H. Pan, et al., J. Agric. Food Chem. 55, 7777 (2007) , (12) B. Billack, et al., Cell. Mol. Biol. Lett. 13, 553 (2008) , (13) C.M. Remsberg, et al., Phytother. Res. 22, 169 (2008) , (14) M. Cichocki, et al., Mol. Nutr. Food Res. 52, S62 (2008) , (15) M.H. Pan, et al., Carcinogenesis 30, 1234 (2009)

Cell permeable natural methoxylated analog of resveratrol. Antioxidant, antiproliferative, anti-inflammatory, anti-hyperglycemic and anti-diabetic agent. Induces apoptosis. Induces Autophagy. Pterostilbene is a naturally-occurring dimethyl ether analog of resveratrol that is abundant in blueberries. Like resveratrol, pterostilbene acts as a powerful antioxidant, suppresses the synthesis of prostaglandin E2 from lipopolysaccharide-stimulated human peripheral blood mononuclear cells (IC50 = 1.0 ?M for pterostilbene, 3.2 ?M for resveratrol), and inhibits cell proliferation (IC50 = ~60 ?M for both compounds). Very potent inhibitor of cytochrome P450 1A1 (CYP1A1) with Ki=0.57µM. Pterostilbene blocks the activation of ERK1/2, p38 MAPK, and PI3K/Akt signaling pathways, reducing NF-?B and AP-1 transcriptional activation. Moderately inhibits COX-1 and COX-2 (IC50=19.8µM and 83.9µM).

SKU: P0234 Category: Phytochemicals

Additional information

Additional information

Synonyms	trans-3,5-Dimethoxy-4'-Hydroxystilbene, 4-[(1E)-2-(3,5-Dimethoxyphenyl)ethenyl]phenol, 3',5'-Dimethoxy-4-Stilbenol
Purity	≥97% (HPLC)
Appearance	Off-white to yellow powder
CAS-Number	537-42-8
Molecular Formula	C16H16O3
Molecular Weight	256.30
Identity	1H-NMR
Solvents	DMSO (20 mg/ml), methanol (10 mg/ml), DMF (30 mg/ml), ethanol (30 mg/ml), water (insoluble)
Melting Point	89-92 °C
Smiles	OC(C=C1)=CC=C1/C=C/C2=CC(OC)=CC(OC)=C2
InChi Key	VLEUZFDZJKSGMX-ONEGZZNKSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements	H318-H411
Precautionary statements	P273-P280-P305 + P351 + P338
GHS Symbol	GHS05+GHS09
Signal word	Danger
RIDADR	UN 3077 9
Transportation	Packing Group III
References	(1) M. Manickam, et al., J. Nat. Prod. 60, 609 (1997), (2) A.M. Rimando, et al., J. Agric. Food Chem. 50, 3453 (2002), (3) M. Roberti, et al., J. Med. Chem. 46, 3546 (2003), (4) R. Amorati, et al., J. Org. Chem. 69, 7101 (2004), (5) S. Hougee, et al., Planta Med. 71, 387 (2005), (6) P. Ferrer, et al., Neoplasia 7, 37 (2005), (7) A.M. Rimando, et al., J. Agric. Food Chem. 53, 3403 (2005), (8) R. Mikstacka, et al., Xenobiotica 36, 269 (2006), (9) K.A. Roupe, et al., Curr. Clin. Pharmacol. 1, 81 (2006), (10) R. Mikstacka, et al., Mol. Nutr. Food Res. 51, 517 (2007), (11) M.H. Pan, et al., J. Agric. Food Chem. 55, 7777 (2007), (12) B. Billack, et al., Cell. Mol. Biol. Lett. 13, 553 (2008), (13) C.M. Remsberg, et al., Phytother. Res. 22, 169 (2008), (14) M. Cichocki, et al., Mol. Nutr. Food Res. 52, S62 (2008), (15) M.H. Pan, et al., Carcinogenesis 30, 1234 (2009)
Quantity	10 mg, 100 mg, Bulk