Specifications
- Purity
- ≥97% (HPLC)
- Appearance
- Off-white to yellow powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (20 mg/ml), methanol (10 mg/ml), DMF (30 mg/ml), ethanol (30 mg/ml), water (insoluble)
- Melting Point
- 89-92 °C
Category: Phytochemicals
Cell permeable natural methoxylated analog of resveratrol. Antioxidant, antiproliferative, anti-inflammatory, anti-hyperglycemic and anti-diabetic agent. Induces apoptosis. Induces Autophagy. Pterostilbene is a naturally-occurring dimethyl ether analog of resveratrol that is abundant in blueberries. Like resveratrol, pterostilbene acts as a powerful antioxidant, suppresses the synthesis of prostaglandin E2 from lipopolysaccharide-stimulated human peripheral blood mononuclear cells (IC50 = 1.0 ?M for pterostilbene, 3.2 ?M for resveratrol), and inhibits cell proliferation (IC50 = ~60 ?M for both compounds). Very potent inhibitor of cytochrome P450 1A1 (CYP1A1) with Ki=0.57µM. Pterostilbene blocks the activation of ERK1/2, p38 MAPK, and PI3K/Akt signaling pathways, reducing NF-?B and AP-1 transcriptional activation. Moderately inhibits COX-1 and COX-2 (IC50=19.8µM and 83.9µM).
Synonyms | trans-3,5-Dimethoxy-4'-Hydroxystilbene, 4-[(1E)-2-(3,5-Dimethoxyphenyl)ethenyl]phenol, 3',5'-Dimethoxy-4-Stilbenol |
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Purity | ≥97% (HPLC) |
Appearance | Off-white to yellow powder |
CAS-Number | 537-42-8 |
Molecular Formula | C16H16O3 |
Molecular Weight | 256.30 |
Identity | 1H-NMR |
Solvents | DMSO (20 mg/ml), methanol (10 mg/ml), DMF (30 mg/ml), ethanol (30 mg/ml), water (insoluble) |
Melting Point | 89-92 °C |
Smiles | OC(C=C1)=CC=C1/C=C/C2=CC(OC)=CC(OC)=C2 |
InChi Key | VLEUZFDZJKSGMX-ONEGZZNKSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Hazard statements | H318-H411 |
Precautionary statements | P273-P280-P305 + P351 + P338 |
GHS Symbol | GHS05+GHS09 |
Signal word | Danger |
RIDADR | UN 3077 9 |
Transportation | Packing Group III |
References | (1) M. Manickam, et al., J. Nat. Prod. 60, 609 (1997), (2) A.M. Rimando, et al., J. Agric. Food Chem. 50, 3453 (2002), (3) M. Roberti, et al., J. Med. Chem. 46, 3546 (2003), (4) R. Amorati, et al., J. Org. Chem. 69, 7101 (2004), (5) S. Hougee, et al., Planta Med. 71, 387 (2005), (6) P. Ferrer, et al., Neoplasia 7, 37 (2005), (7) A.M. Rimando, et al., J. Agric. Food Chem. 53, 3403 (2005), (8) R. Mikstacka, et al., Xenobiotica 36, 269 (2006), (9) K.A. Roupe, et al., Curr. Clin. Pharmacol. 1, 81 (2006), (10) R. Mikstacka, et al., Mol. Nutr. Food Res. 51, 517 (2007), (11) M.H. Pan, et al., J. Agric. Food Chem. 55, 7777 (2007), (12) B. Billack, et al., Cell. Mol. Biol. Lett. 13, 553 (2008), (13) C.M. Remsberg, et al., Phytother. Res. 22, 169 (2008), (14) M. Cichocki, et al., Mol. Nutr. Food Res. 52, S62 (2008), (15) M.H. Pan, et al., Carcinogenesis 30, 1234 (2009) |
Quantity | 10 mg, 100 mg, Bulk |