Available from stock

Pyridoxal 5′-phosphate monohydrate

SKU: P0461

Category: Vitamins

Synonyms: P5P , PLP , Codecarboxylase , 3-Hydroxy-2-methyl-5-([phosphonooxy]methyl)-4-pyridinecarboxaldehyde , Pyridoxal 5-phosphate , Vitamin B6 Metabolite; 41468-25-1
CAS-Number: C₈H₁₀NO₆P · H₂O
Molecular Formula: 265.16
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥99% (HPLC)
Appearance: White to off-white powder
Identity: 1H-NMR

Properties

Solvents: water (slightly)
Melting Point: 140-143 °C (lit.)

Shipping: AMBIENT
Short Term Storage: +4°C
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Transportation: Not dangerous goods

Description: The enzyme cofactor Pyridoxal-5?-phosphate monohydrate is a vitamin B6 metabolite that can modify lysyl and valyl residues in proteins. It acts as a coenzyme in transamination reactions by forming a Schiff-base linkage with lysine groups on aminotransferase. Also serves as a coenzyme in some decarboxylation and deamination reactions. It has the ability to inhibit purinergic receptors and intracellular influx of Ca2+. Pyridoxal-5?-phosphate monohydrate can modify peptides and suppress their precursor ionization efficiency. Research shows that pyridoxal-5?-phosphate-dependent enzymes can be inhibited by cycloserine.
InChi Key: CEEQUQSGVRRXQI-UHFFFAOYSA-N
References: (1) D.E. Kandzari, et al., Am. J. Cardiol. 92, 660 (2003) , (2) D.W. Kim, et al., J. Biochem. Mol. Biol. 38, 58 (2005) , (3) J.C. Tardif, et al., J. Thorac. Cardiovasc. Surg. 133, 1604 (2007) , (4) M. Neuwirth, et al., FEBS Lett. 583, 2179 (2009) , (5) E.S. Simon, et al., Rapid Commun. Mass Spectrom 23, 3401 (2009) , (6) J. Lowther, et al., Mol Biosyst. 6, 1682 (2010) , (7) J.L. Hedrick, Adv. Biochem. Psychopharmacol. 4, 23 (1972) , (8) B.I. Yang & D.E. Metzler, Methods Enzymol. 62, 528 (1979) , (9) G. Tunnicliff & T.T. Ngo, Cell Physiol. Biochem. 8, 117 (1998) , (10) P. Christen & P.K. Mehta, Chem. Rec. 1, 436 (2001) , (11) M.L. di Salvo, et al., Front. Biosci 4, 897 (2012) , (12) L. Paul, et al., Nutr. Rev. 71, 239 (2013)

The enzyme cofactor Pyridoxal-5?-phosphate monohydrate is a vitamin B6 metabolite that can modify lysyl and valyl residues in proteins. It acts as a coenzyme in transamination reactions by forming a Schiff-base linkage with lysine groups on aminotransferase. Also serves as a coenzyme in some decarboxylation and deamination reactions. It has the ability to inhibit purinergic receptors and intracellular influx of Ca2+. Pyridoxal-5?-phosphate monohydrate can modify peptides and suppress their precursor ionization efficiency. Research shows that pyridoxal-5?-phosphate-dependent enzymes can be inhibited by cycloserine.

SKU: P0461 Category: Vitamins

Additional information

Additional information

Synonyms	P5P, PLP, Codecarboxylase, 3-Hydroxy-2-methyl-5-([phosphonooxy]methyl)-4-pyridinecarboxaldehyde, Pyridoxal 5-phosphate, Vitamin B6 Metabolite
Purity	≥99% (HPLC)
Appearance	White to off-white powder
CAS-Number	41468-25-1
Molecular Formula	C8H10NO6P · H2O
Molecular Weight	265.16
Identity	1H-NMR
Solvents	water (slightly)
Melting Point	140-143 °C (lit.)
InChi Key	CEEQUQSGVRRXQI-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Transportation	Not dangerous goods
References	(1) D.E. Kandzari, et al., Am. J. Cardiol. 92, 660 (2003), (2) D.W. Kim, et al., J. Biochem. Mol. Biol. 38, 58 (2005), (3) J.C. Tardif, et al., J. Thorac. Cardiovasc. Surg. 133, 1604 (2007), (4) M. Neuwirth, et al., FEBS Lett. 583, 2179 (2009), (5) E.S. Simon, et al., Rapid Commun. Mass Spectrom 23, 3401 (2009), (6) J. Lowther, et al., Mol Biosyst. 6, 1682 (2010), (7) J.L. Hedrick, Adv. Biochem. Psychopharmacol. 4, 23 (1972), (8) B.I. Yang & D.E. Metzler, Methods Enzymol. 62, 528 (1979), (9) G. Tunnicliff & T.T. Ngo, Cell Physiol. Biochem. 8, 117 (1998), (10) P. Christen & P.K. Mehta, Chem. Rec. 1, 436 (2001), (11) M.L. di Salvo, et al., Front. Biosci 4, 897 (2012), (12) L. Paul, et al., Nutr. Rev. 71, 239 (2013)
Quantity	5 g, 25 g, Bulk