Available from stock

Rebaudioside A

SKU: R0090

Category: Carbohydrates

Synonyms: Glycoside A3 , Glycoside X , Stevioside A3 , Reb A; 58543-16-1
CAS-Number: C₄₄H₇₀O₂₃
Molecular Formula: 967.01
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: White powder

Properties

Solvents: water (10 mg/ml), DMSO
Melting Point: 242 - 244 °C
Optical Activity: [α]/D -33.0±3.0°, c = 1% in H2O

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: RT
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at RT.

Transportation: Not dangerous goods

Description: Rebaudioside A is a glucosylated steviol glycoside studied and used as a non-glycemic sweetener. It is one of the predominant steviol glycosides isolated from S. rebaudiana leaves. Rebaudioside A is a α-glucosidase inhibitor with (IC50=35?g/ml) and can inhibit ATP-sensitive K+-channels. In vitro rebaudioside A stimulated the insulin secretion from MIN6 cells in a dose- and glucose-dependent manner. It increases glucagon-like peptide 1 (GLP-1) secretion in a 2-dimensional mouse intestine moδ Rebaudioside A is metabolized by gut microbiota to steviol. Rebaudioside A shows antioxidant activity on reducing cellular reactive oxygen species. It is an activator of Nrf2 and is a potential candidate hepatoprotective agent.
Smiles: C=C1[C@@]2(O[C@H]3[C@H](O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)[C@@H](O[C@H]5[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O5)[C@H](O)[C@@H](CO)O3)C[C@]6(C1)CC[C@]7([H])[C@](C)(C(O[C@H]8[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8)=O)CCC[C@@]7(C)[C@]6([H])CC2
InChi Key: HELXLJCILKEWJH-NCGAPWICSA-N
References: (1) R. Abudula, et al., Metab.53, 1378 (2004) , (2) R. Abudula, et al., Diabetes Obes. Metab. 10, 1074 (2008) , (3) D.J. Brusick, Food Chem. Toxicol. 46, S83 (2008) , (4) M. Upreti, et al., Molecules 17, 4186 (2012) , (5) D. Ripken, et al., J. Agric. Food Chem. 62, 8365 (2014) , (6) N. van der Wielen, et al., J. Nutr. 146, 2429 (2016) , (7) D.H. Shin, et al., Diabetes Metab. J. 40, 283 (2016) , (8) B.R. Adari, et al., Food Chem. 200, 154 (2016) , (9) Y. Wang, et al., Eur. J. Pharmacol. 822, 128 (2018)
InChi: ###############################################################################################################################################################################################################################################################

Rebaudioside A is a glucosylated steviol glycoside studied and used as a non-glycemic sweetener. It is one of the predominant steviol glycosides isolated from S. rebaudiana leaves. Rebaudioside A is a α-glucosidase inhibitor with (IC50=35?g/ml) and can inhibit ATP-sensitive K+-channels. In vitro rebaudioside A stimulated the insulin secretion from MIN6 cells in a dose- and glucose-dependent manner. It increases glucagon-like peptide 1 (GLP-1) secretion in a 2-dimensional mouse intestine moδ Rebaudioside A is metabolized by gut microbiota to steviol. Rebaudioside A shows antioxidant activity on reducing cellular reactive oxygen species. It is an activator of Nrf2 and is a potential candidate hepatoprotective agent.

SKU: R0090 Category: Carbohydrates

Additional information

Additional information

Synonyms	Glycoside A3, Glycoside X, Stevioside A3, Reb A
Purity	≥98% (HPLC)
Appearance	White powder
CAS-Number	58543-16-1
Molecular Formula	C44H70O23
Molecular Weight	967.01
Solvents	water (10 mg/ml), DMSO
Melting Point	242 – 244 °C
Optical Activity	[α]/D -33.0±3.0°, c = 1% in H2O
Smiles	C=C1[C@@]2(O[C@H]3[C@H](O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)[C@@H](O[C@H]5[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O5)[C@H](O)[C@@H](CO)O3)C[C@]6(C1)CC[C@]7([H])[C@](C)(C(O[C@H]8[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8)=O)CCC[C@@]7(C)[C@]6([H])CC2
InChi Key	HELXLJCILKEWJH-NCGAPWICSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	RT
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at RT.
Transportation	Not dangerous goods
References	(1) R. Abudula, et al., Metab.53, 1378 (2004), (2) R. Abudula, et al., Diabetes Obes. Metab. 10, 1074 (2008), (3) D.J. Brusick, Food Chem. Toxicol. 46, S83 (2008), (4) M. Upreti, et al., Molecules 17, 4186 (2012), (5) D. Ripken, et al., J. Agric. Food Chem. 62, 8365 (2014), (6) N. van der Wielen, et al., J. Nutr. 146, 2429 (2016), (7) D.H. Shin, et al., Diabetes Metab. J. 40, 283 (2016), (8) B.R. Adari, et al., Food Chem. 200, 154 (2016), (9) Y. Wang, et al., Eur. J. Pharmacol. 822, 128 (2018)
InChi	###############################################################################################################################################################################################################################################################
Quantity	5 g, 25 g, 50 g, Bulk