Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (30 mg/ml), DMF (30 mg/ml), ethanol (20 mg/ml)
- Melting Point
- 129-130 °C
Downloads
- Safety Data Sheet
- CDX R0122 MSDS.pdf
Category: API's & Intermediates
Repaglinide is a metaglitinide antidiabetic agent. It is a potent short-acting insulin secretagogue that acts by closing ATP-sensitive potassium (KATP) channels in the plasma membrane of the pancreatic beta cell. It represents a new class of insulin secretagogues, structurally unrelated to sulphonylureas, which were developed for the treatment of type 2 diabetes. Repaglinide shows also antioxidant and anti-inflammatory properties.
Synonyms | (S)-(+)-2-Ethoxy-4-[N-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoic acid, Novonorm, Prandin |
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Purity | ≥98% (HPLC) |
Appearance | White to off-white powder |
CAS-Number | 135062-02-1 |
Molecular Formula | C27H36N2O4 |
Molecular Weight | 452.59 |
Identity | 1H-NMR |
Solvents | DMSO (30 mg/ml), DMF (30 mg/ml), ethanol (20 mg/ml) |
Melting Point | 129-130 °C |
Smiles | O=C(CC1=CC(OCC)=C(C(O)=O)C=C1)N[C@@H](CC(C)C)C2=CC=CC=C2N3CCCCC3 |
InChi Key | FAEKWTJYAYMJKF-QHCPKHFHSA-N |
Shipping | AMBIENT |
Short Term Storage | RT |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Transportation | Not dangerous goods |
References | (1) B.H. Wolffenbuttel, et al., Eur. J. Clin. Pharmacol. 45, 113 (1993), (2) J. Gromada, et al., Diabetologia 38, 1025 (1995), (3) D.R. Owens, Eur. J. Clin. Invest. 29, 30 (1999) (Review), (4) V. Ambavane, et al., J. Postgrad. Med. 48, 246 (2002) (Review), (5) A.M. Hansen, et al., Br. J. Pharmacol. 144, 551 (2005), (6) A. Gumieniczek, et al., Pharmacol. Res. 52, 162 (2005), (7) D. Tung, et al., Pharmacology 88, 295 (2011), (8) P. Kuhner, et al., Naunyn Schmiedebergs Arch. Pharmacol. 385, 299 (2012), (9) L.J. Scott, Drugs 72, 249 (2012) (Review), (10) D. Ding, et al., Cell Rep. 27, 1848 (2019) |
InChi | InChI=1S/C27H36N2O4/c1-4-33-25-17-20(12-13-22(25)27(31)32)18-26(30)28-23(16-19(2)3)21-10-6-7-11-24(21)29-14-8-5-9-15-29/h6-7,10-13,17,19,23H,4-5,8-9,14-16,18H2,1-3H3,(H,28,30)(H,31,32)/t23-/m0/s1 |
Quantity | 50 mg, 250 mg, Bulk |