Rutin trihydrate

SKU: R0066

Category: Phytochemicals

Synonyms: Rutoside , Phytomelin , Sophorin , Birutan , Eldrin , Birutan Forte , Globularicitrin , Violaquercitrin , Quercetin rutinoside; 250249-75-3
CAS-Number: C₂₇H₃₀O₁₆
Molecular Formula: 610.52
Molecular Weight

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥95% (HPLC)
Appearance: Light yellow powder

Properties

Melting Point: 195°C
Solvents: DMSO, pyridine

Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at RT.
Long Term Storage: RT
Short Term Storage: RT
Shipping: AMBIENT

Transportation: Not dangerous goods
Signal word: Warning
GHS Symbol: GHS07
Precautionary statements: P264, P270, P301+P312, P330, P501
Hazard statements: H302

Description: A polyphenolic flavonoid that acts as an antioxidant and NO scavenger. It can attenuate peroxide production in glial cells by acting as a free radical scavenger and protect renal cells from oxidative injury. Inclusion of rutin in the diet of rats significantly reduced the appearance of single-strand breaks in nuclear DNA caused by hepatocarcinogens aflatoxin B1 and N-nitrosodiumethylamine. This protection from DNA damage was found to be due to a reduction in the induction of repair enzymes polymerase, DNA polymerase ? and DNA ligase. Since DNA damage and inefficient repair are thought to initiate the process of carcinogenesis, effects of rutin on these functions suggests a protective role of this flavonoid against carcinogenesis induced by chemical carcinogens. Rutin ameliorates obesity through brown fat activation.
InChi: InChI=1S/C27H30O16/c1-8-17(32)20(35)22(37)26(40-8)39-7-15-18(33)21(36)23(38)27(42-15)43-25-19(34)16-13(31)5-10(28)6-14(16)41-24(25)9-2-3-11(29)12(30)4-9/h2-6,8,15,17-18,20-23,26-33,35-38H,7H2,1H3/t8?,15-,17+,18-,20-,21+,22-,23-,26-,27+/m1/s1
References: I.B. Afanas'ev, et al., Biochem. Pharmacol. 38, 1763 (1989) , R.P. Webster, et al., Cancer Lett. 109, 185 (1996) , E.A. Ostrakhovitch & I.B. Afanas'ev, Biochem. Pharmacol. 62, 743 (2001) , N. Kamalakkannan & P.S. Prince, Basic Clin. Pharmacol. Toxicol. 98, 97 (2006) , J.P. Lin, et al., Leuk. Res. 33, 823 (2009) , R. Lapa Fda, et al., J. Pharm. Pharmacol. 63, 875 (2011) , S.W. Wang, et al., Neurotoxicology 33, 482 (2012) , X. Yuan, et al., FASEB J. 31, 333 (2016)
InChi Key: IKGXIBQEEMLURG-KAOWGYSOSA-N
Smiles: O=C1C2=C(O)C=C(O)C=C2OC(C3=CC(O)=C(O)C=C3)=C1O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]5[C@H](O)[C@H](O)[C@@H](O)C(C)O5)O4

A polyphenolic flavonoid that acts as an antioxidant and NO scavenger. It can attenuate peroxide production in glial cells by acting as a free radical scavenger and protect renal cells from oxidative injury. Inclusion of rutin in the diet of rats significantly reduced the appearance of single-strand breaks in nuclear DNA caused by hepatocarcinogens aflatoxin B1 and N-nitrosodiumethylamine. This protection from DNA damage was found to be due to a reduction in the induction of repair enzymes polymerase, DNA polymerase ? and DNA ligase. Since DNA damage and inefficient repair are thought to initiate the process of carcinogenesis, effects of rutin on these functions suggests a protective role of this flavonoid against carcinogenesis induced by chemical carcinogens. Rutin ameliorates obesity through brown fat activation.

SKU: R0066 Category: Phytochemicals

Additional information

Additional information

Synonyms	Rutoside, Phytomelin, Sophorin, Birutan, Eldrin, Birutan Forte, Globularicitrin, Violaquercitrin, Quercetin rutinoside
Purity	≥95% (HPLC)
Appearance	Light yellow powder
CAS-Number	250249-75-3
Molecular Formula	C27H30O16
Molecular Weight	610.52
Solvents	DMSO, pyridine
Melting Point	195°C
Smiles	O=C1C2=C(O)C=C(O)C=C2OC(C3=CC(O)=C(O)C=C3)=C1O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]5[C@H](O)[C@H](O)[C@@H](O)C(C)O5)O4
InChi Key	IKGXIBQEEMLURG-KAOWGYSOSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	RT
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at RT.
Hazard statements	H302
Precautionary statements	P264, P270, P301+P312, P330, P501
GHS Symbol	GHS07
Signal word	Warning
Transportation	Not dangerous goods
References	I.B. Afanas'ev, et al., Biochem. Pharmacol. 38, 1763 (1989), R.P. Webster, et al., Cancer Lett. 109, 185 (1996), E.A. Ostrakhovitch & I.B. Afanas'ev, Biochem. Pharmacol. 62, 743 (2001), N. Kamalakkannan & P.S. Prince, Basic Clin. Pharmacol. Toxicol. 98, 97 (2006), J.P. Lin, et al., Leuk. Res. 33, 823 (2009), R. Lapa Fda, et al., J. Pharm. Pharmacol. 63, 875 (2011), S.W. Wang, et al., Neurotoxicology 33, 482 (2012), X. Yuan, et al., FASEB J. 31, 333 (2016)
InChi	InChI=1S/C27H30O16/c1-8-17(32)20(35)22(37)26(40-8)39-7-15-18(33)21(36)23(38)27(42-15)43-25-19(34)16-13(31)5-10(28)6-14(16)41-24(25)9-2-3-11(29)12(30)4-9/h2-6,8,15,17-18,20-23,26-33,35-38H,7H2,1H3/t8?,15-,17+,18-,20-,21+,22-,23-,26-,27+/m1/s1
Quantity	100 g, 500 g, Bulk