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    Rutin trihydrate

    Available from stock

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      Rutin trihydrate

      SKU
      R0066

      Category: Phytochemicals

      Synonyms
      Rutoside , Phytomelin , Sophorin , Birutan , Eldrin , Birutan Forte , Globularicitrin , Violaquercitrin , Quercetin rutinoside
      250249-75-3
      CAS-Number
      C27H30O16
      Molecular Formula
      610.52
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥95% (HPLC)
      Appearance
      Light yellow powder

      Properties

      Melting Point
      195°C
      Solvents
      DMSO, pyridine

      Downloads

      Safety Data Sheet
      CDX R0066 MSDS.pdf
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at RT.
      Long Term Storage
      RT
      Short Term Storage
      RT
      Shipping
      AMBIENT
      Transportation
      Not dangerous goods
      Signal word
      Warning
      GHS Symbol
      GHS07
      Precautionary statements
      P264, P270, P301+P312, P330, P501
      Hazard statements
      H302
      Description
      A polyphenolic flavonoid that acts as an antioxidant and NO scavenger. It can attenuate peroxide production in glial cells by acting as a free radical scavenger and protect renal cells from oxidative injury. Inclusion of rutin in the diet of rats significantly reduced the appearance of single-strand breaks in nuclear DNA caused by hepatocarcinogens aflatoxin B1 and N-nitrosodiumethylamine. This protection from DNA damage was found to be due to a reduction in the induction of repair enzymes polymerase, DNA polymerase ? and DNA ligase. Since DNA damage and inefficient repair are thought to initiate the process of carcinogenesis, effects of rutin on these functions suggests a protective role of this flavonoid against carcinogenesis induced by chemical carcinogens. Rutin ameliorates obesity through brown fat activation.
      InChi
      InChI=1S/C27H30O16/c1-8-17(32)20(35)22(37)26(40-8)39-7-15-18(33)21(36)23(38)27(42-15)43-25-19(34)16-13(31)5-10(28)6-14(16)41-24(25)9-2-3-11(29)12(30)4-9/h2-6,8,15,17-18,20-23,26-33,35-38H,7H2,1H3/t8?,15-,17+,18-,20-,21+,22-,23-,26-,27+/m1/s1
      References
      I.B. Afanas'ev, et al., Biochem. Pharmacol. 38, 1763 (1989) , R.P. Webster, et al., Cancer Lett. 109, 185 (1996) , E.A. Ostrakhovitch & I.B. Afanas'ev, Biochem. Pharmacol. 62, 743 (2001) , N. Kamalakkannan & P.S. Prince, Basic Clin. Pharmacol. Toxicol. 98, 97 (2006) , J.P. Lin, et al., Leuk. Res. 33, 823 (2009) , R. Lapa Fda, et al., J. Pharm. Pharmacol. 63, 875 (2011) , S.W. Wang, et al., Neurotoxicology 33, 482 (2012) , X. Yuan, et al., FASEB J. 31, 333 (2016)
      InChi Key
      IKGXIBQEEMLURG-KAOWGYSOSA-N
      Smiles
      O=C1C2=C(O)C=C(O)C=C2OC(C3=CC(O)=C(O)C=C3)=C1O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]5[C@H](O)[C@H](O)[C@@H](O)C(C)O5)O4

      A polyphenolic flavonoid that acts as an antioxidant and NO scavenger. It can attenuate peroxide production in glial cells by acting as a free radical scavenger and protect renal cells from oxidative injury. Inclusion of rutin in the diet of rats significantly reduced the appearance of single-strand breaks in nuclear DNA caused by hepatocarcinogens aflatoxin B1 and N-nitrosodiumethylamine. This protection from DNA damage was found to be due to a reduction in the induction of repair enzymes polymerase, DNA polymerase ? and DNA ligase. Since DNA damage and inefficient repair are thought to initiate the process of carcinogenesis, effects of rutin on these functions suggests a protective role of this flavonoid against carcinogenesis induced by chemical carcinogens. Rutin ameliorates obesity through brown fat activation.

      SKU: R0066 Category: Phytochemicals
      • Additional information

      Additional information

      Synonyms

      Rutoside, Phytomelin, Sophorin, Birutan, Eldrin, Birutan Forte, Globularicitrin, Violaquercitrin, Quercetin rutinoside

      Purity

      ≥95% (HPLC)

      Appearance

      Light yellow powder

      CAS-Number

      250249-75-3

      Molecular Formula

      C27H30O16

      Molecular Weight

      610.52

      Solvents

      DMSO, pyridine

      Melting Point

      195°C

      Smiles

      O=C1C2=C(O)C=C(O)C=C2OC(C3=CC(O)=C(O)C=C3)=C1O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]5[C@H](O)[C@H](O)[C@@H](O)C(C)O5)O4

      InChi Key

      IKGXIBQEEMLURG-KAOWGYSOSA-N

      Shipping

      AMBIENT

      Short Term Storage

      RT

      Long Term Storage

      RT

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at RT.

      Hazard statements

      H302

      Precautionary statements

      P264, P270, P301+P312, P330, P501

      GHS Symbol

      GHS07

      Signal word

      Warning

      Transportation

      Not dangerous goods

      References

      I.B. Afanas'ev, et al., Biochem. Pharmacol. 38, 1763 (1989), R.P. Webster, et al., Cancer Lett. 109, 185 (1996), E.A. Ostrakhovitch & I.B. Afanas'ev, Biochem. Pharmacol. 62, 743 (2001), N. Kamalakkannan & P.S. Prince, Basic Clin. Pharmacol. Toxicol. 98, 97 (2006), J.P. Lin, et al., Leuk. Res. 33, 823 (2009), R. Lapa Fda, et al., J. Pharm. Pharmacol. 63, 875 (2011), S.W. Wang, et al., Neurotoxicology 33, 482 (2012), X. Yuan, et al., FASEB J. 31, 333 (2016)

      InChi

      InChI=1S/C27H30O16/c1-8-17(32)20(35)22(37)26(40-8)39-7-15-18(33)21(36)23(38)27(42-15)43-25-19(34)16-13(31)5-10(28)6-14(16)41-24(25)9-2-3-11(29)12(30)4-9/h2-6,8,15,17-18,20-23,26-33,35-38H,7H2,1H3/t8?,15-,17+,18-,20-,21+,22-,23-,26-,27+/m1/s1

      Quantity

      100 g, 500 g, Bulk

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